Faculty profile
James Woodgett
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Read how they describe their research on their University of Toronto profile.
Latest papers
Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart.
Circulation research · 2022
Glycogen synthase kinase-3β inhibits tubular regeneration in acute kidney injury by a FoxM1-dependent mechanism.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
Isoform-specific requirement for GSK3α in sperm for male fertility.
Biology of reproduction · 2018
Latest funding
- $3,062,890
Functional Genomics of Neurodegenerative Diseases: Defining Molecular Pathogenesis and Targets for Biomarkers and Personalised Therapies
CIHR · 2018 · Co-investigator
- $993,851
Medulloblastoma Metastases are Hematogenous, and Driven by Expression of CCL2
CIHR · 2016 · Co-investigator
- $2,572,263
Genetic analysis of signal transduction pathways involved in human diseases.
CIHR · 2014 · Nominated PI
7 publications.
Fibroblast GSK-3α Promotes Fibrosis via RAF-MEK-ERK Pathway in the Injured Heart.
Umbarkar P, Tousif S, Singh AP, Anderson JC, Zhang Q, Tallquist MD, Woodgett J, Lal H
Glycogen synthase kinase-3β inhibits tubular regeneration in acute kidney injury by a FoxM1-dependent mechanism.
Sinha S, Dwivedi N, Woodgett J, Tao S, Howard C, Fields TA, Jamadar A, Rao R
Isoform-specific requirement for GSK3α in sperm for male fertility.
Bhattacharjee R, Goswami S, Dey S, Gangoda M, Brothag C, Eisa A, Woodgett J, Phiel C, Kline D, Vijayaraghavan S
The GSK-3 family as therapeutic target for myocardial diseases.
Lal H, Ahmad F, Woodgett J, Force T
Cardiac fibroblast glycogen synthase kinase-3β regulates ventricular remodeling and dysfunction in ischemic heart.
Lal H, Ahmad F, Zhou J, Yu JE, Vagnozzi RJ, Guo Y, Yu D, Tsai EJ, Woodgett J, Gao E, Force T
Clinical uses of microarrays in cancer research.
Virtanen C, Woodgett J
Cardioprotective stress response in the human fetal heart.
Coles JG, Boscarino C, Takahashi M, Grant D, Chang A, Ritter J, Dai X, Du C, Musso G, Yamabi H, Goncalves J, Kumar AS, Woodgett J, Lu H, Hannigan G
Functional Genomics of Neurodegenerative Diseases: Defining Molecular Pathogenesis and Targets for Biomarkers and Personalised Therapies
Principal investigators: ST GEORGE-HYSLOP, Peter H
Keywords: Alzheimer Disease; Biomarkers; Frontotemporal Lobar Degeneration; Functional Genetics Of Risk Genes; Intrinsically Disordered Phase Separating Proteins; Neurological Disorders; Therapeutic Targets
Medulloblastoma Metastases are Hematogenous, and Driven by Expression of CCL2
Principal investigators: Taylor, Michael D
Keywords: Brain Tumors; Mouse Models; Pediatric Cancer; Xenografts
Genetic analysis of signal transduction pathways involved in human diseases.
Principal investigators: Woodgett, James (Jim) R
Keywords: Cell Regulation; Diabetes; Metabolism; Oncogene; Protein Kinase; Signal Transduction; Stem Cell; Transgenic Mouse
Wnt signaling: biomarker and target evaluation in Alzheimer's disease
Principal investigators: Woodgett, James (Jim) R
Keywords: Alzheimers Disease; Biomarkers; Canonical; Cell Biology; Mouse Models; Neurodegeneration; Signal Transduction; Wnt Signaling
Investigation of the roles of GSK-3 isoforms in mediating Abeta, tau and insulin related Alzheimer-like synaptic, cholinergic impairments
Principal investigators: Woodgett, James (Jim) R; ST GEORGE-HYSLOP, Peter H; Zhang, Wandong
Keywords: Cell Culture; Electrophysiology; Mouse Model; Neuroanatomy; Neurobehaviour; Signal Transduction; Transgenic/Knockout
2012 Synapse Mentorship Award (Research Group) The Samuel lunenfeld Research Institute (SLRI)
Principal investigators: Woodgett, James (Jim) R
Keywords: Dna; Scihigh
Addressing tumor heterogeneity through identification of subgroup-specific "shared maintenance genes" - the right target for each cancer
Principal investigators: Egan, Sean E; Taylor, Michael D; Woodgett, James (Jim) R; Zacksenhaus, Eldad
Keywords: Breast Cancer; Medulloblastoma; Metastasis; Oncogene Addiction; P53; Pi3k; Rb; Shared Maintenance Genes; Shh; Wnt
Functional roles of glycogen synthase kinase-3 in cellular regulation and cancer
Principal investigators: Woodgett, James (Jim) R
Keywords: Beta-Catenin; Colon Cancer; Development; Lymphoma; Protein Kinase; Stem Cell
Canadian Network for Vaccines and Immunotherapeutics of Cancer and Chronic Viral Diseases (CANVAC) (2006 Renewal Competition)
Principal investigators: Sekaly, RafickPierre
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.