Jeremy Mogridge, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Pathogenesis Innate immunity Clinical toxicology Molecular genetics Biochemistry

Latest papers

NLRP1B allele 2 does not respond to Val-boro-Pro (VbP) in intestinal epithelial cells.
Microbes and infection · 2024
Activation of the NLRP1B inflammasome by caspase-8.
Communications biology · 2024 · senior author
Listeria monocytogenes and Shigella flexneri Activate the NLRP1B Inflammasome.
Infection and immunity · 2017 · senior author

All 21 publications

Latest funding

Assembly of the Anthrax Toxin Protein Translocase
CIHR · 2014 · Nominated PI
$658,800

All 1 grants and awards

21 publications.

01

NLRP1B allele 2 does not respond to Val-boro-Pro (VbP) in intestinal epithelial cells.

Mazzone RJ, Winsor NJ, Li LY, Barry KT, Ranger A, Goyal S, Meade JJ, Bruce J, Philpott DJ, Mogridge J, Girardin SE

Microbes and infection2024

DOI: 10.1016/j.micinf.2024.105398 PMID: 39047896

02

Activation of the NLRP1B inflammasome by caspase-8.

Meade JJ, Stuart S, Neiman-Zenevich J, Krustev C, Girardin SE, Mogridge J

Communications biology2024Senior author

DOI: 10.1038/s42003-024-06882-3 PMID: 39289441

03

Listeria monocytogenes and Shigella flexneri Activate the NLRP1B Inflammasome.

Neiman-Zenevich J, Stuart S, Abdel-Nour M, Girardin SE, Mogridge J

Infection and immunity2017Senior author

DOI: 10.1128/iai.00338-17 PMID: 28808162

04

Identification of the inflammasome Nlrp1b as the candidate gene conferring diabetes risk at the Idd4.1 locus in the nonobese diabetic mouse.

Motta VN, Markle JG, Gulban O, Mortin-Toth S, Liao KC, Mogridge J, Steward CA, Danska JS

Journal of immunology (Baltimore, Md. : 1950)2015

DOI: 10.4049/jimmunol.1400913 PMID: 25964492

05

Using light scattering to determine the stoichiometry of protein complexes.

Mogridge J

Methods in molecular biology (Clifton, N.J.)2015First author

DOI: 10.1007/978-1-4939-2425-7_14 PMID: 25859953

06

Distinct regions of NLRP1B are required to respond to anthrax lethal toxin and metabolic inhibition.

Neiman-Zenevich J, Liao KC, Mogridge J

Infection and immunity2014Senior author

DOI: 10.1128/iai.02167-14 PMID: 24935976

07

A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formation.

Dennis MK, Mogridge J

Biochemistry2014Senior author

DOI: 10.1021/bi5000756 PMID: 24641616

08

Activation of the Nlrp1b inflammasome by reduction of cytosolic ATP.

Liao KC, Mogridge J

Infection and immunity2013Senior author

DOI: 10.1128/iai.01003-12 PMID: 23230290

09

Binding of filamentous actin to anthrax toxin receptor 1 decreases its association with protective antigen.

Garlick KM, Batty S, Mogridge J

Biochemistry2012Senior author

DOI: 10.1021/bi2016469 PMID: 22303962

10

Proteolytic processing of Nlrp1b is required for inflammasome activity.

Frew BC, Joag VR, Mogridge J

PLoS pathogens2012Senior author

DOI: 10.1371/journal.ppat.1002659 PMID: 22536155

Assembly of the Anthrax Toxin Protein Translocase

Nominated PICIHR2014Operating Grant

Principal investigators: Mogridge, Jeremy

Keywords: Anthrax; Bacterial Toxin; Membrane Protein; Translocase

$658,800

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Subject: Prospective PhD student: Pathogenesis Dear Professor Mogridge, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "NLRP1B allele 2 does not respond to Val-boro-Pro (VbP) in intestinal epithelial cells." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]