Faculty profile
John Rubinstein
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Read how they describe their research on their University of Toronto profile.
Latest papers
WITHDRAWN: Characterization of the supercomplex formed by the alternative complex III and the terminal aa3 oxidase from Flavobacterium johnsoniae isolated in styrene:maleic acid copolymer nanodiscs.
Biochimica et biophysica acta. Bioenergetics · 2018
Latest funding
- $120,000
Understanding regulation of V-ATPase in health and disease
CIHR · 2025 · Supervisor
- $1,197,226
Structure, regulation, and dysregulation of V-ATPase in the synaptic vesicle cycle
CIHR · 2024 · Nominated PI
- $135,000
Unravelling the role of V-ATPase in synaptic vesicle loading and neurotransmitter release: regulation and implications in neurological disease
CIHR · 2023 · Supervisor
1 publications.
WITHDRAWN: Characterization of the supercomplex formed by the alternative complex III and the terminal aa3 oxidase from Flavobacterium johnsoniae isolated in styrene:maleic acid copolymer nanodiscs.
Venkatakrishnan P, Benlekbir S, Sun C, Hong S, Hosler J, Rubinstein J, Gennis RB
Understanding regulation of V-ATPase in health and disease
Principal investigators: Khamina, Mariia
Keywords: Disease Mechanism; Electron Cryomicroscopy; Intracellular Ph Regulation; Rare Pediatric Disorders; Vacuolar Atpase
Structure, regulation, and dysregulation of V-ATPase in the synaptic vesicle cycle
Principal investigators: Rubinstein, John L
Keywords: Bioenergetics; Cryoem; Membrane Proteins; Rave Complex; Synaptic Vesicles; Tldc Proteins; V-Atpase
Unravelling the role of V-ATPase in synaptic vesicle loading and neurotransmitter release: regulation and implications in neurological disease
Principal investigators: Coupland, Claire E
Keywords: Biochemistry; Biophysics; Cryo-Electron Microscopy; Membrane Proteins; Neurological Diseases; Neurotransmitter Release; Protein Regulation; Structural Biology; Synaptic Vesicle Loading; V-Atpases
Methods for high-resolution cryoEM of scarce and short-lived macromolecular structures
Principal investigators: Rubinstein, John
Keywords: Computation; Electron cryomicroscopy; Freezing; Instrumentation; Membrane proteins; Protein structure; Specimen preparation; Structural biology; Time-resolved
Structural analysis of the Plasmodium V-ATPase bound to antimalarial lead compounds.
Principal investigators: Karimi, Ryan
Keywords: Drug Development; Electron Cryomicroscopy; Malaria; Vacuolar Atpase
Understanding mycobacterial oxidative phosphorylation and targeting it to treat tuberculosis
Principal investigators: Rubinstein, John L
Keywords: Atp Synthase; Cryoem; Electron Transport Chain; Inhibitors; Membrane Proteins; Mycobacteria; Oxidative Phosphorylation; Structural Biology; Therapeutics; Tuberculosis
Structural and biophysical characterization of mycobacterial NADH dehydrogenases
Principal investigators: Liang, Yingke
Keywords: Bacterial Metabolism; Electron Cryomicroscopy; Infectious Disease; Membrane Proteins; Protein Dynamics; Structural Biology; Tuberculosis
Elucidating the effects of histone core oncomutations on the structure and dynamics of nucleosomes and nucleosomal arrays
Principal investigators: Huang, Shuya K
Keywords: Cancer; Chromatin; Electron Cryomicroscopy; Histone; Nuclear Magnetic Resonance Spectroscopy; Nucleosome; Structural Biology
The Development of Novel Neuroactive Compounds to Combat Parasitic Nematodes
Principal investigators: Roy, Peter J
Keywords: Anthelmintics; C. Elegans; Chemical Genetics; Infection; Nematicide; Nervous System; Parasitic Nematodes; Small Molecule Screens; Synapse; Vesicular Acetylcholine Transporter (Vacht)
Mechanistic analysis of the mycobacterial CIII2CIV2 supercomplex by cryoEM to develop new antimycobacterial agents.
Principal investigators: Yanofsky, David
Keywords: Antibiotics; Cryoem; Drug Design; Oxidative Phosphorylation; Structural Biology; Tuberculosis
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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Profile data last refreshed on September 25, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.