Julie Lefebvre

Synapse specificity and function in the cerebellum by Usher Syndrome-linked cadherins.

Principal investigators: Lefebvre, Julie L

Keywords: Cadherin; Cerebellum; Electrophysiology; Gabaergic Inhibitory Interneurons; Microscopy; Mossy Fiber Synapse; Mouse Transgenic Models; Sensorimotor Integration; Synapse Formation; Synapse Transmission

Investigating Developmental and Therapeutic Photoreceptor Connectivity in the Mammalian Retina

Principal investigators: Wallace, Valerie A

Keywords: Mouse Model; Neurite; Photoreceptor; Retina; Synapse; Viral Vectors

A synthetic ligand-receptor platform to map and manipulate cellular interactions in intact nervous systems.

Principal investigators: Lefebvre, Julie L

Keywords: Cancer Neuroscience; Cell-Cell Interaction Reporter; Fluorescent Reporters, Opsins And Sensors; Neural Circuit Analysis; Neuron-Glia Interactions; Neurotechnology; Synthetic Biology; Trans-Synaptic Tracing Technology; Transgenic Mice; Viral Vector Transduction

Decoding neural circuit formation and miswiring in the developing and injured cerebellum.

Principal investigators: Moke, Benjamin-Israel

Keywords: Cell Adhesion Molecules; Cerebellum; Development; Hypoxia; Neural Circuit Connectivity; Transcriptomics

Mapping the cellular and molecular wiring of neurons into circuits

Principal investigators: Lefebvre, Julie

Keywords: Cell surface receptors and adhesion molecules; Dendrite morphology; Live imaging; Mouse transgenic models; Neural circuit; Neuron; RNA labeling; single-cell RNA sequencing; Synapse; Visual system

Balancing inhibitory interneuron number and connectivity in the developing neocortex.

Principal investigators: Lefebvre, Julie L

Keywords: Activity-Dependent Pathways; Clustered Protocadherins; Cortical Development; Electrophysiology; Epilepsy; Gabaergic Inhibitory Interneuron; Inhibitory Synapses; Mouse Transgenic Models; Programmed Cell Death; Single-Molecule Rna In Situ Hybridization

Canada Research Chair - Tier 2

Principal investigators: Lefebvre, Julie L

Keywords: Crc

Molecular mechanisms to organize neurons into circuits

Principal investigators: Lefebvre, Julie

Regulation of inhibitory interneuron development and circuit assembly by Protocadherins

Principal investigators: Lefebvre, Julie L

Keywords: Cell Adhesion Molecules; Cerebellum; Electrophysiology; Mouse Genetics; Neural Circuit Formation; Neuroanatomical Studies; Neuron Cell Biology; Neuron Survival; Neuronal Development; Synapse

Assembly of inhibitory circuits in the normal and premature cerebellum

Principal investigators: Gray, Madison T

Keywords: Axon Guidance; Cerebellum; Hypoxia; Inhibitory Interneurons; Neural Circuit Assembly; Neuroanatomy; Neurodevelopment; Prematurity