Lewis Kay

Investigating the critical roles of histone dynamics for nucleosome core particle functions in health and disease: A solution NMR spectroscopy study

Principal investigators: Kay, Lewis E

Keywords: Electrostatics; Histone Code; Histone Dynamics; Ligand Binding; Nucleosome Core Particle; Oncohistones; Post-Translational Modifications; Solution Nmr Spectroscopy To Study Conformational Dynamics; Structure-Dynamics-Function Paradigm

Solution NMR studies of functional conformational equilibria of poly(ADP-ribose) polymerase 1 in the presence of drug molecules, interactors, and posttranslational modifications

Principal investigators: Roessler, Philip

Keywords: Cancer; Inhibitors; Nmr Spectroscopy; Parp; Parpi; Poly (Adp-Ribose); Protein Dynamics; Synthetic Lethality

Developing the NMR toolkit for atomic resolution studies of phase separation

Principal investigators: Kay, Lewis

Keywords: nmr spectoscopy; nmr methods development; phase separation; biomolecular strutural dynamics; biomolecular interactions; proteins; nucleic acids; biomolecular energy landscapes

Unveiling the energy landscapes of interleukins using NMR spectroscopy

Principal investigators: Bonin, Jeffrey P

Keywords: Cancer; Immunity; Inflammation; Interleukins; Nuclear Magnetic Resonance Spectroscopy; Protein Dynamics; Protein Energy Landscapes

Proposed Helium Recovery System for the UofT/Sick Kids Biomolecular NMR Facility

Principal investigators: Kay, Lewis

Elucidating the effects of histone core oncomutations on the structure and dynamics of nucleosomes and nucleosomal arrays

Principal investigators: Huang, Shuya K

Keywords: Cancer; Chromatin; Electron Cryomicroscopy; Histone; Nuclear Magnetic Resonance Spectroscopy; Nucleosome; Structural Biology

Cellular destruction at the atomic level: understanding the dynamic activation and regulation of caspase proteases

Principal investigators: Alderson, Thomas R

Keywords: Alzheimer'S; Apoptosis; Apoptosome; Cancer; Caspase; Dementia; Nuclear Magnetic Resonance (Nmr); Structural Biology; Tau

Probing the structural dynamics of human mitochondrial protease HtrA2 by methyl-TROSY NMR

Principal investigators: Toyama, Yuki

Keywords: Dynamics; Htra2; Methyl-Trosy; Nuclear Magnetic Resonance Spectroscopy; Parkinson'S Disease; Protease; Protein Quality Control

Structural dynamics of nucleosome core particles upon DNA methylation and MeCP2 binding

Principal investigators: Bolik-Coulon, Nicolas

Keywords: Dna Methylation; Dna-Protein Interactions; Electron Cryo-Microscopy; Mecp2; Methyl-Trosy; Neurodegenerative Diseases; Nuclear Magnetic Resonance; Nucleosome; Protein And Dna Dynamics

Investigating the structural, biophysical and biochemical properties of liquid-liquid phase separation in neurological disorders.

Principal investigators: Kim, Tae Hun

Keywords: Amyotrophic Lateral Sclerosis; Autism Spectrum Disorder; Fluorescence Microscope Imaging; Intrinsically Disordered Proteins; Liquid-Liquid Phase Separation; Nmr Spectroscopy