Maruti Uppalapati

Research

Allosteric Inhibitors Computational Protein Design Directed Evolution Drug Design Enzyme Engineering Molecular Biology Molecular Switches Structural Biology

Latest papers

Effects of binding partners on thermal reversion rates of photoswitchable molecules.
Proceedings of the National Academy of Sciences of the United States of America · 2025
A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.
ACS chemical biology · 2021
A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.
ACS chemical biology · 2016 · first author

All 4 publications

Latest funding

5th Protein Engineering Canada Conference, 2024
CIHR · 2024 · Principal investigator
$15,000

All 1 grants and awards

4 publications.

01

Effects of binding partners on thermal reversion rates of photoswitchable molecules.

Reed PMM, Jang J, Woloschuk RM, Reis J, Hille JIC, Uppalapati M, Woolley GA

Proceedings of the National Academy of Sciences of the United States of America2025

DOI: 10.1073/pnas.2414748122 PMID: 40035753

02

A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth.

Marinec PS, Landgraf KE, Uppalapati M, Chen G, Xie D, Jiang Q, Zhao Y, Petriello A, Deshayes K, Kent SBH, Ault-Riche D, Sidhu SS

ACS chemical biology2021

DOI: 10.1021/acschembio.1c00017 PMID: 33621466

03

A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo.

Uppalapati M, Lee DJ, Mandal K, Li H, Miranda LP, Lowitz J, Kenney J, Adams JJ, Ault-Riché D, Kent SB, Sidhu SS

ACS chemical biology2016First author

DOI: 10.1021/acschembio.5b01006 PMID: 26745345

04

KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression.

Ahmed SM, Thériault BL, Uppalapati M, Chiu CW, Gallie BL, Sidhu SS, Angers S

The Journal of cell biology2012

DOI: 10.1083/jcb.201206051 PMID: 23209302

5th Protein Engineering Canada Conference, 2024

Principal investigatorCIHR2024Planning and Dissemination Grant - Institute Community Support

Principal investigators: Woolley, Andrew G; Uppalapati, Maruti

Keywords: Allosteric Inhibitors; Computational Protein Design; Directed Evolution; Drug Design; Enzyme Engineering; Molecular Biology; Molecular Switches; Structural Biology

$15,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Maruti Uppalapati

Medical Imaging

1 shared papers, latest 2025

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Allosteric Inhibitors Dear Professor Uppalapati, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Effects of binding partners on thermal reversion rates of photoswitchable molecules." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "5th Protein Engineering Canada Conference, 2024" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]