Penney Gilbert

A strategy for using machine intelligence to design high-capacity viral vectors that evade pre-existing immunity and enable gene therapies for diseases involving defects in large genes.

Principal investigators: Garton, Michael J

Keywords: Viral Vector Design

Evaluating the nerve-muscle connection as a Duchenne muscular dystrophy therapeutic target

Principal investigators: Gilbert, Penney M; Stewart, Bryan A

Keywords: Disease Modelling; Drug Development; Duchenne Muscular Dystrophy; Neuromuscular Junction; Pluripotent Stem Cells; Skeletal Muscle; Tissue Engineering

Regulation of satellite stem cell fate by LINC complex proteins

Principal investigators: Gilbert, Penney M

Keywords: Emery Dreifuss Muscular Dystrophy; Linc Complex; Satellite Cells; Skeletal Muscle

Extracellular matrix grafts for the treatment of volumetric muscle loss

Principal investigators: Bentzinger, Florian CF

Evaluating Duchenne muscular dystrophy treatments with a 3D innervated skeletal muscle model

Principal investigators: Jacques, Erik

Keywords: Cell Isolation-Induced Activation; In Silico; Muscle Stem Cell-Niche Interactions; Muscle Stem Cells; Quiescence Induction; Untangling Musc-Niche Communication Relating To Quiescence

An automated manufacturing and high speed imaging platform for identifying functional perturbations in engineered tissues

Principal investigators: McGuigan, Alison

Evaluating Duchenne muscular dystrophy treatments with a 3D innervated skeletal muscle model

Principal investigators: Jacques, Erik

Keywords: Duchenne Muscular Dystrophy; Pre-Clinical Studies; Skeletal Muscle; Tissue Modeling

Manufacturing and scaling of an in vitro human skeletal muscle phenotypic assay (I2I Phase I)

Principal investigators: McGuigan, Alison

Endogenous Repair

Principal investigators: Gilbert, Penney

Canadian COVID-19 Prospective Cohort Study (CanCOV)

Principal investigators: Cheung, Angela M; Ahmed, Sofia B; Batt, Jane Andrea E; Binnie, Alexandra; Dos Santos, Claudia C; Ghassemi, Marzyeh; Herridge, Margaret S; Lamontagne, Francois; Morin, Suzanne N; Palepu, Anita; Razak, Fahad; Stelfox, Henry T; Strug, Lisa J; Tsang, Jennifer L; Verma, Amol; Yeung, Rae S

Keywords: Caregiver Health; Clinical Presentations & Trajectories; Full Spectrum Of Covid-19 Disease (Mild To Severe); Host Genetic Profiling; Knowledge To Action Cycles; Mental Health & Stigma; Prediction Models Using Machine Learning; Prospective Cohort Study; Sociodemographic And Clinical Predictors Of Outcomes; Transcriptomic, Epigenomic And Immunologic Host Response