Faculty profile
Rachel Tyndale
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Read how they describe their research on their University of Toronto profile.
Latest papers
Effects of open-label transdermal nicotine antidepressant augmentation on affective symptoms and executive function in late-life depression.
Journal of affective disorders · 2024
Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020
Latest funding
- $100,000
The SWAGAT Study: Smoking cessation and Weight gain Attenuation with dual Glucagon like Peptide Receptor & Gastric Inhibitory Receptor Agonist- Tirzepatide: A double blinded RCT.
CIHR · 2026 · Co-investigator
- $726,750
Impact of Genomic Factors in Accidental Lethal Opioid Overdose
CIHR · 2025 · Co-investigator
- $1,468,800
A Phase II Multi-Site, Double-Blind, Randomized, Sham-Controlled, Clinical Trial of Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder
CIHR · 2025 · Co-investigator
2 publications.
Effects of open-label transdermal nicotine antidepressant augmentation on affective symptoms and executive function in late-life depression.
Andrews P, Vega JN, Szymkowicz SM, Newhouse P, Tyndale R, Elson D, Kang H, Siddiqi S, Tyner EB, Mather K, Gunning FM, Taylor WD
Genome-Wide Meta-Analyses of FTND and TTFC Phenotypes.
Chen J, Loukola A, Gillespie NA, Peterson R, Jia P, Riley B, Maes H, Dick DM, Kendler KS, Damaj MI, Miles MF, Zhao Z, Li MD, Vink JM, Minica CC, Willemsen G, Boomsma DI, Qaiser B, Madden PAF, Korhonen T, Jousilahti P, Hällfors J, Gelernter J, Kranzler HR, Sherva R, Farrer L, Maher B, Vanyukov M, Taylor M, Ware JJ, Munafò MR, Lutz SM, Hokanson JE, Gu F, Landi MT, Caporaso NE, Hancock DB, Gaddis NC, Baker TB, Bierut LJ, Johnson EO, Chenoweth M, Lerman C, Tyndale R, Kaprio J, Chen X
The SWAGAT Study: Smoking cessation and Weight gain Attenuation with dual Glucagon like Peptide Receptor & Gastric Inhibitory Receptor Agonist- Tirzepatide: A double blinded RCT.
Principal investigators: Selby, Peter L; Agarwal, Sri Mahavir; Melamed, Osnat; Mir, Hassan; Patton, Ian T; Tang, Victor M; Veldhuizen, Scott R; Zawertailo, Laurie A
Keywords: Addiction; Cardiometabolic Risk; Gastric Inhibitory Peptide; Glucagon-Like Peptide-1 Receptor Agonist; Nicotine Dependence; Obesity; Overweight; Smoking Cessation; Tobacco Use Disorder; Trizepatide
Impact of Genomic Factors in Accidental Lethal Opioid Overdose
Principal investigators: Mueller, Daniel J; Le Foll, Bernard
Keywords: Genomics; Lethal Overdose; Opioids; Pharmacogenetics; Polygenic Risk Scores; Substance Use Disorder
A Phase II Multi-Site, Double-Blind, Randomized, Sham-Controlled, Clinical Trial of Repetitive Transcranial Magnetic Stimulation for Cannabis Use Disorder
Principal investigators: Tang, Victor M; Blumberger, Daniel M; MacKillop, James
Keywords: Addiction; Cannabis; Cannabis Use Disorder; Neuromodulation; Transcranial Magnetic Stimulation
Investigating the Interplay between FAAH and Opioid Misuse in Chronic Pain
Principal investigators: Boileau, Isabelle; Le Foll, Bernard; Moayedi, Massieh
Keywords: Chronic Non-Cancer Pain; Endocannabinoid System; Fatty Acid Amide Hydrolase (Faah); Opioid Use Disorder; Positron Emission Tomography
Fatty Acid Amide Hydrolase in Brain of Youth With High-risk Alcohol Use: Positron Emission Tomography Studies With [11C]CURB
Principal investigators: Boileau, Isabelle; Hendershot, Christian S
Keywords: Alcohol Use Disorder; Endocannabinoid System; Fatty Acid Amide Hydrolase; Heavy Drinking; Positron Emission Tomography; Youth
Canada Research Chair - Tier 1
Principal investigators: Tyndale, Rachel F
Keywords: Crc
Influence of polygenic risk scores on longitudinal disease trajectories of individuals with schizophrenia spectrum disorders
Principal investigators: Kennedy, James L; Tiwari, Arun K; Zai, Clement
Keywords: Disease Severity; Functional Outcomes; Pharmacogenetics; Response; Schizophrenia; Schizophrenia Spectrum Disorders; Side Effects
Uncovering the biological liability to migraine and anxiety in women
Principal investigators: Chenoweth, Meghan J
Keywords: Anxiety; Genetics; Genome-Wide Association Study; Mendelian Randomization; Migraine; Sex And Gender Differences; Underfunded Diseases
Imputation of CYP2A6 structural genetic variants for use in CYP2A6 activity predictors
Principal investigators: Langlois, Alec
Keywords: Cyp2a6; Genetic Risk Scores; Imputation; Lung Cancer; Nicotine Metabolism; Personalized Medicine; Pharmacogenetics; Smoking; Structural Variants
Understanding the Pathophysiology of Social Anxiety using Endocannabinoid Neuroimaging with the Fatty Acid Amide Hydrolase (FAAH) Tracer [C-11]CURB
Principal investigators: Kloiber, Stefan M; Boileau, Isabelle
Keywords: Endocannabinoid System; Social Anxiety Disorder
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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Profile data last refreshed on September 26, 2026 from the university directory, publication records and CIHR, NSERC and SSHRC funding.