Régis Pomes

Uncovering the structural basis for the mechanical properties of elastin

Principal investigators: Pomes, Régis; Sharpe, Simon J

Keywords: Biophysical Techniques; Elastic Recoil; Elastin; Mechanical Properties; Molecular Dynamics Simulations; Protein Phase Separation; Self-Assembled Elastomeric Proteins; Solid State And Solution Nmr; Structural Biology; Structure-Function Studies

Rational design of non-immunogenic elastin-based materials for applications in drug delivery

Principal investigators: Pomès, Régis

Computational Studies of Biomolecular Structure and Function

Principal investigators: Pomès, Régis

Theoretical Studies of Ion Translocation in Membrane Proteins

Principal investigators: Pomes, Régis

Keywords: Computer Simulations; Cytochrome C Oxidase; Free Energy Calculations; Ion Channels; Ion Translocation; Ionic Selectivity; Molecular Mechanism; Single-Channel Conductance; Sodium Channel; Voltage-Gated Proton Channel

Uncovering the molecular basis of biological energy conversion in cells: Proton transport in vacuolar ATPases studied through electron cryomicroscopy and molecular simulations

Principal investigators: Whitford, Paul C

Keywords: Bioenergetics; Biophysics; Electron Cryomicroscopy; Membrane Protein Dynamics; Molecular Simulations

A protein on the edge: balancing structural order and disorder in the assembly of elastin. Implications for vascular pathology.

Principal investigators: Keeley, Fred W

Keywords: Amyloid; Aorta; Assembly; Elastin; Structure; Vascular

Structure-function studies of methionine recyclying enzymes

Principal investigators: Howell, Patricia L

Keywords: Anti-Microbial Drug Design; Methionine Recycling; Site-Directed Mutagenesis; Structure-Based Drug Design; X-Ray Crystallogrpahy

Accelerating biomolecular simulations using a large scale, FPGA-based multiprocessor

Principal investigators: Chow, Paul