This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.
Research
Latest papers
Bile acid dependent attenuation of toxin mediated disease is independent of colonization resistance against C. difficile.
bioRxiv : the preprint server for biology · 2026
Latest funding
- $1,028,925
Development and delivery of de novo designed antitoxins for the treatment and prevention of toxin-driven intestinal diseases
CIHR · 2025 · Nominated PI
- $20,000
13th International Conference on Molecular Biology and Pathogenesis of Clostridia (Clostpath)
CIHR · 2023 · Nominated PI
- $104,000
Molecular mechanisms of bacterial toxin translocation into cells
NSERC · 2023 · Principal investigator
1 publications.
Bile acid dependent attenuation of toxin mediated disease is independent of colonization resistance against C. difficile.
Kisthardt SC, Perkins CE, Gancz AS, Lyons NS, Thomas SA, Vincent EC, Zhang G, Tam J, Melnyk R, Rose EC, Baker ES, Theriot CM
Development and delivery of de novo designed antitoxins for the treatment and prevention of toxin-driven intestinal diseases
Principal investigators: Melnyk, Roman
Keywords: C. Difficile; De Novo Design; Enteric Pathogens; Rfdiffusion; S.Boulardii; Synthetic Biotic; Toxins
13th International Conference on Molecular Biology and Pathogenesis of Clostridia (Clostpath)
Principal investigators: Melnyk, Roman
Keywords: Clostridia; Conference; Global Health Treat; Infection; Pathogen
Molecular mechanisms of bacterial toxin translocation into cells
Principal investigators: Melnyk, Roman
Keywords: BioID; Conformational change; Membrane; Proximity; Receptor; Toxin; Translocation
COVID-19 Variant Supplement - Rapid development of antiviral compounds to fight the COVID-19 outbreak
Principal investigators: Sidhu, Sachdev S
Keywords: Coronavirus; Deubiquitinase; Displacement Assay; Enzyme Inhibition; Infectious Diseases; Protein Engineering; Small Molecules; Structural Biology; Therapeutics; Ubiquitin
Rapid development of antiviral compounds to fight the COVID-19 outbreak
Principal investigators: Sidhu, Sachdev S
Keywords: Coronavirus; Deubiquitinase; Displacement Assay; Enzyme Inhibition; Infectious Diseases; Protein Engineering; Small Molecules; Structural Biology; Therapeutics; Ubiquitin
Development of a tumour-targeted RAS-specific protease for pancreatic cancer therapy
Principal investigators: Melnyk, Roman
Keywords: Antibodies; Biologics; Pancreatic Cancer; Therapeutics
Natural and artificial evolution of toxin-receptor interactions
Principal investigators: Taipale, Mikko; Melnyk, Roman
Keywords: Clostridium Difficile; Crispr/Cas9; Crispr/Cas9 Screening; Large Clostridial Toxins
Taking the "idiopathic" out of scoliosis: from biology and genetics to non-invasive therapies
Principal investigators: Ciruna, Brian G
Keywords: Cerebrospinal Fluid; Csf-Contacting Neurons; Developmental Genetics; Idiopathic Scoliosis; Motile Cilia; Neuroinflammation; Pre-Clinical Models; Small Molecule Screens; Whole Genome Sequencing; Zebrafish Models Of Human Disease
Developing Targeted Therapies for Rare and Common Forms of Inflammatory Bowel Disease
Principal investigators: Muise, Aleixo M
Keywords: Drug Screening; Genetics; Inflammatory Bowel Disease; Monogenic Defects; Pediatrics; Zebrafish
Elucidating a new role for bile acids in protecting against C. difficile toxin pathogenesis: Implications for therapy
Principal investigators: Melnyk, Roman
Keywords: Antibiotics; Bile Acids; Clostridium Difficile; Fmt; Therapy
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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