Sara Vasconcelos

Advancing Microvessel-Based Cardiac Regeneration

Principal investigators: Zhou, Angela

Keywords: Angiogenesis; Cardiac Regeneration; Cell-Replacement Therapy; Intravital Imaging; Microvesels; Regenerative Medicine; Vascularization

Enabling novel cardiac therapies with pluripotent stem cells

Principal investigators: Laflamme, Michael

Keywords: Cardiac regeneration; Pluripotent stem cells; Cell manufacturing; Heart failure; Synthetic biology; Tissue engineering; Biomedical imaging; 3D bioprinting; Mathematical modeling; Health technology assessment; Bioethics

Myocardial regeneration in a pre-clinical model of type 2 diabetes

Principal investigators: Vasconcelos, Sara N

Keywords: Cardiomyocyte; Diabetes; Myocardial Infarction; Regenerative Medicine; Stem Cells; Vascularization

Contribution of endothelial fatty acid metabolism to diabetes-associated heart failure with preserved ejection fraction

Principal investigators: Fish, Jason E

Keywords: Biomarker; Diabetes; Endothelial Cell; Extracellular Vesicles; Fatty Acid; Heart Failure; Metabolism; Microrna; Microvascular; Therapy

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

Principal investigators: Keshavjee, Shaf

Keywords: Immunology; Immunotolerance; Organ transplantation; Ex vivo organ perfusion; Gene modification; Cell therapy; Translational research; Organ repair; Medical ethics; Biomedical engineering; Patient-centred approach; Precision medicine

The Next Frontier in Transplantation: Ex vivo Strategies to Repair and Rebuild Organs

Principal investigators: Keshavjee, Shaf

Keywords: Immunology Immunotolerance Organ transplantation Ex vivo organ perfusion Gene modification Cell therapy Translational research Organ repair Medical ethics Biomedical engineering Patient-centred approach Precision medicine

Using novel transplantation strategies and HLA-edited hypoimmunogenic hPSCs to develop a superior islet-like product for T1D treatment

Principal investigators: Nostro, Maria Cristina; Drucker, Daniel J; Korbutt, Gregory S; Pepper, Andrew R; Vasconcelos, Sara N

Keywords: Beta Cells; Directed Differentiation; Hla-Editing; Human Pluripotent Stem Cells; Humanized Mice; Regenerative Medicine; Transplantation; Type 1 Diabetes

Investigating the influence of biomimetic cues in cardiovascular system formation

Principal investigators: Vasconcelos, Sara

Accelerating vascularization and blood perfusion for cell transplantation and myocardial regeneration

Principal investigators: Vasconcelos, Sara N

Keywords: Cardiomyocyte; Myocardial Infarction; Pre-Vascularization; Regeneration; Stem Cells; Tissue Engineering

Training program in organ-on-a-chip engineering and entrepreneurship (TOeP)

Principal investigators: Radisic, Milica