Steffen Bolz

Imaging microvascular dysfunction: a new paradigm for early detection of heart failure

Principal investigators: Cheng, Hai-Ling M

Keywords: Diabetes; Echocardiography; Heart Failure; Magnetic Resonance Imaging; Microvascular Dysfunction; Photoacoustics; Preserved Ejection Fraction

Specifically targeting CFTR activity as a therapeutic strategy to normalize cerebral blood flow in heart failure

Principal investigators: Bolz, Steffen S

Keywords: Cerebral Blood Flow; Cognitive Decline; Cystic Fibrosis Transmembrane Conductance Regulator (Cftr); Gene Deletion; Heart Failure; Isolated Resistance Arteries; Neuronal Injury; Sphingosine-1-Phosphate (S1p); Therapeutic Intervention; Vascular Smooth Muscle

Developmental Pathways to Health and Disease: Fetal Programming and Protection

Principal investigators: Matthews, Stephen G

Keywords: Blood-Brain-Barrier; Fetus; Glucocorticoids; Human Development; Maternal/Child Health; Neuroendocrinology; Perinatal; Pregnancy; Programming; Stress Physiology

Constitutive Smooth Muscle Tumor Necrosis Factor Regulates Microvascular Myogenic Responsiveness and Systemic Blood Pressure

Principal investigators: Bolz, Steffen S

Keywords: Conditional Knockout; Etanercept; Human Vessels; Infliximab; Myogenic Tone; Signal Transduction; Tumour Necrosis Factor

Smooth muscle TNF/S1P signalling drives reduced cerebral perfusion in heart failure.

Principal investigators: Bolz, Steffen S

Keywords: Cerebral Blood Flow; Chronic Heart Failure; Conditional Knockout; Myogenic Tone; Sphingosine Kinase 1; Sphingosine-1-Phosphate Signalling; Tumour Necrosis Factor

Clinical application of novel chip-based technology for determination of sphingosine-1-phosphate-dependence of microvessel dysfunction in patients with heart failure

Principal investigators: Hui, Sonya K

Keywords: Artery-On-A-Chip Platform; Cardiovascular Disease; Heart Failure; Human Tissue; Microfluidics; Myogenic Response; Resistance Arteries; Sphingosine-1-Phosphate Signaling; Translational Research; Tumour Necrosis Factor-Alpha

The role of tumor necrosis factor alpha in control of microvascular tone in a mouse model of type 2 diabetes mellitus

Principal investigators: Sauve, Meghan G

Keywords: Cardiovascular Disease; Hypertension; Myogenic Tone; Perfusion Myography; Resistance Level Arteries; Sphingosine Kinase 1; Sphingosine-1-Phosphate; Tumor Necrosis Factor Alpha; Type 1 And Type 2 Diabetes Mellitus; Vascular Complications Of Diabetes Mellitus

Artery-on-a-Chip PACE Platform

Principal investigators: Guenther, Axel