Steven Prescott

Inferring ion channel densities by fitting computational models to excitability data: pitfalls and improvements

Principal investigators: Prescott, Steven

Keywords: neuron; excitability; ion channels; optimization; computational neuroscience; parameter estimation; degeneracy; neurophysiology; modeling

Homeostatic regulation failure in epilepsy renders cortical circuits less heterogeneous

Principal investigators: Rich, Scott

Keywords: Applied Mathematics; Computational Neuroscience; Epilepsy; Mathematical Modeling; Neural Networks; Neuron Models; Neuronal Degeneracy; Neuronal Homeostasis; Rhythms And Oscillations; Seizure

Impact of chloride dysregulation on pain processing in the spinal dorsal horn

Principal investigators: Medlock, Laura M

Keywords: Chronic Pain; Computational Modeling; Network Model; Neuropathic Pain; Pain Processing; Primary Afferents; Sensory Coding; Somatosensation; Spinal Cord; Vibrotactile

Optimizing spinal cord stimulation and other electroceutical treatments by modulating neural activity with strategically designed electric fields

Principal investigators: Shifman, Aaron

Keywords: Biophysics; Electric Field Modeling; Neuronal Dynamics; Spinal Cord Stimulators

Neuropathic pain through misregulated excitability and abnormal neural coding

Principal investigators: Prescott, Steven

Keywords: Calcium Imaging; Computational Neuroscience; Electrophysiology; Excitability; Neural Coding; Optogenetics; Pain; Somatosensory

Investigating how mechanosensitive neurons contribute to allodynia in neuropathic pain

Principal investigators: Al-Basha, Dhekra

Keywords: In Vivo Electrophysiology; Optogenetics; Pain; Somatosensation; Spike Initiation Properties

Chloride dysregulation and neuropathic pain: Linking molecular mechanisms with altered pain processing via identification of cellular and circuit level changes

Principal investigators: Prescott, Steven

Keywords: Allodynia; Chloride; Dorsal Horn; Kcc2; Neural Circuits; Neural Coding; Neuropathic Pain; Neurophysiology; Somatosensation; Synaptic Inhibition

Probing the spike initiation properties of primary somatosensory neurons using optogenetics

Principal investigators: Prescott, Steven

Keywords: Action Potential; Calcium Imaging; Computational Neuroscience; Computer Modeling; Electrophysiology; Neurophysiology; Nociception; Optogenetics; Sensory Systems; Somatosensation

Probing the spike initiation properties of primary somatosensory neurons using optogenetics

Principal investigators: Prescott, Steven

Keywords: Action Potential; Channelrhodopsin; Excitability; Gcamp; Hyperexcitability; Mechanosensory; Neural Coding; Optogenetics; Primary Afferents; Somatosensation

Neural Dynamics: Their Nonlinear Basis and Computational Consequences

Principal investigators: Prescott, Steve