Voula Kanelis

Bio-layer interferometry system for quantitative analysis of molecular interactions

Principal investigators: Currie, Mark

Keywords: Binding constants; Binding kinetics; Biochemistry; Biophysics; Molecular interactions

Electrophysiology system for comparative structure-function studies of ion channels and neurotransmitter receptors

Principal investigators: Senatore, Adriano

Studies of how disordered regions, post-translational processing, and protein interactions affect the structure, dynamics, and activity of ABC transporters

Principal investigators: Kanelis, Voula

Keywords: atp binding cassette (abc) transporter; membrane protein; nucleotide binding domain; intrinsically disordered regions (idrs); nuclear magnetic resonance (nmr) spectoscopy; electron cryo-microscopy (cryo-em); fluorescence spectroscopy; yeast genetics; protein structure and dynamics; protein-protein interactions

Studies of the effects of phosphorylation and protein interactions on ATP-binding casette transporter activity

Principal investigators: Kanelis, Voula

Examining Biomolecular Interactions using Microscale Thermophoresis

Principal investigators: Moraes, Trevor

Studies of the molecular mechanisms by which mutations in the SUR2A NBDs cause cardiovascular diseases

Principal investigators: Kanelis, Voula

Keywords: Abc Transporters; Fluorescence Spectroscopy; Katp Channels; Nmr Spectroscopy; Nucleotide Binding Domains; Phosphorylation; Protein Dynamics; Protein Structure; Protein-Protein Interactions; Sulfonylurea Receptors

Effects of phosphorylation on the structure and interactions of the sulfonylurea receptor's nucleotide binding domains

Principal investigators: de Araujo, Elvin D

Keywords: Abc Transporters; Fluoresence Spectroscopy; Katp Channels; Nmr Spectroscopy; Nucleotide Binding Domais; Phosphorylation; Protein Dynamics; Protein Structure; Protein-Protein Interactions; Sulfonylurea Receptors

Upgrades for 500 MHz spectrometer to enable protein NMR spectroscopy

Principal investigators: Kanelis, Voula

Studies of the molecular mechanisms by which mutations in the SUR2A NBDs cause cardiovascular diseases

Principal investigators: Kanelis, Voula

Keywords: Atp-Sensitive Potassium Channels; Nmr Spectroscopy; Nucleotide Binding Domains; Phosphorylation; Protein Dynamics; Protein Structure; Protein-Protein Interactions

Investigations into the molecular basis of regulation of ATP-sensitive K+ chaannels by SUR proteins, members of ABC transporters

Principal investigators: Kanelis, Voula