Cheryle Seguin

Ectopic calcification of spinal tissues: leveraging preclinical mouse models and patient samples to investigate therapeutic targets for diffuse idiopathic skeletal hyperostosis (DISH)

Principal investigators: Séguin, Cheryle A

Keywords: Arthritis; Diffuse Idiopathic Skeletal Hyperostosis; Dystrophic Calcification; Human Samples; Mechanical Loading; Metabolomics; Preclinical Mouse Model; Retinoic Acid Receptor; Spatial Profiling; Spine

Immunoregulation of synovial fibroblasts in osteoarthritis

Principal investigators: Blackler, Garth

Keywords: Animal Models; Cellular Communication; Fibroblast; Intervention; Macrophage; Osteoarthritis; Pain; Single Cell Rna Sequencing; Synovium

Investigating the role of PRG4 in intervertebral disc development and its potential as a therapeutic target for disc degeneration

Principal investigators: Ji, Chenfan

Keywords: Animal Model; Back Pain; Embryonic Development; Extracellular Matrix; Intervertebral Disc Degeneration; Prg4; Spine Health

Delivery of induced pluripotent stem cells in cell-instructive composite hydrogels for nucleus pulposus regeneration

Principal investigators: Flynn, Lauren E; Amsden, Brian G

Keywords: Bioreactors; Cell Therapy; Decellularized Tissues; Differentiation; Induced Pluripotent Stem Cells; Intervertebral Disc Degeneration; Mechanically-Resilient Hydrogels; Nucleus Pulposus; Organ Culture; Pre-Clinical Testing

Bioreactor suite to study mechanical loading in skeletal tissues & biomaterials

Principal investigators: Seguin, Cheryle

The role of Pannexin 3 in aging-associated osteoarthritis

Principal investigators: Beier, Frank; Penuela, Silvia

Keywords: Aging; Animal Model; Bone; Cartilage; Ko Mice; Obesity; Osteoarthritis; Pannexin; Patient Samples; Synovium

The role of PGC1alpha in osteoarthritis

Principal investigators: Beier, Frank

Keywords: Bone; Cartilage; Gene Expression; Metabolism; Mitochondria; Mouse Model; Osteoarthritis; Pgc1alpha; Synovium

Regulation of mechanotransduction in the intervertebral disc

Principal investigators: Seguin, Cheryle

Keywords: intervertebral disc; mechanical loading; cell signalling; knockout mice; nucleus pulposus; annulus fibrosus; gene expression; extracellular matrix; transient receptor potential vanilloid 4 (trpv4); calcium signalling

Upgrades to an advanced multiphoton microscope with unique equipment to improve tissue access for intravital imaging and improved image stability

Principal investigators: Kerfoot, Steven

Regulation of mechanotransduction in the intervertebral disc

Principal investigators: Seguin, Cheryle