Gregory Gloor, Western University

Research

Read how they describe their research on their Western University profile.

Conjugative Plasmid Crispr/Tevcas9 Nuclese Designer Nuclease Microbial Ecosystem Manipulation Targeted Antimicrobial Therapeutic

Latest papers

Moderate Renal Impairment and Toxic Metabolites Produced by the Intestinal Microbiome: Dietary Implications.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation · 2019
Metabolic products of the intestinal microbiome and extremes of atherosclerosis.
Atherosclerosis · 2018
The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens.
Scientific reports · 2016

All 4 publications

Latest funding

Precision microbiome editing with CRISPR nucleases
CIHR · 2023 · Co-investigator
$937,125
Metabolic and Metagenomic effects of repopulation of the intestinal microbiome in patients with severe unexplained atherosclerosis
CIHR · 2019 · Co-investigator
$321,300
ConCRISPR: Conjugative delivery of a hybrid CRISPR/Tev nuclease system for specific microbiota modulation in the mammalian gut
CIHR · 2018 · Principal investigator
$891,226

All 10 grants and awards

4 publications.

01

Moderate Renal Impairment and Toxic Metabolites Produced by the Intestinal Microbiome: Dietary Implications.

Pignanelli M, Bogiatzi C, Gloor G, Allen-Vercoe E, Reid G, Urquhart BL, Ruetz KN, Velenosi TJ, Spence JD

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation2019

DOI: 10.1053/j.jrn.2018.05.007 PMID: 30100156

02

Metabolic products of the intestinal microbiome and extremes of atherosclerosis.

Bogiatzi C, Gloor G, Allen-Vercoe E, Reid G, Wong RG, Urquhart BL, Dinculescu V, Ruetz KN, Velenosi TJ, Pignanelli M, Spence JD

Atherosclerosis2018

DOI: 10.1016/j.atherosclerosis.2018.04.015 PMID: 29702430

03

The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens.

Petrova MI, Lievens E, Verhoeven TL, Macklaim JM, Gloor G, Schols D, Vanderleyden J, Reid G, Lebeer S

Scientific reports2016

DOI: 10.1038/srep37437 PMID: 27869151

04

Impact of technical sources of variation on the hand microbiome dynamics of healthcare workers.

Rosenthal M, Aiello AE, Chenoweth C, Goldberg D, Larson E, Gloor G, Foxman B

PloS one2014

DOI: 10.1371/journal.pone.0088999 PMID: 24551205

Precision microbiome editing with CRISPR nucleases

Co-investigatorCIHR2023Project Grant

Principal investigators: Edgell, David R

Keywords: Antibiotic; Conjugative Plasmids; Crispr/Cas9 Nuclease; Microbiome; Synthetic Biology

$937,125

Metabolic and Metagenomic effects of repopulation of the intestinal microbiome in patients with severe unexplained atherosclerosis

Co-investigatorCIHR2019Project Grant

Principal investigators: Spence, J. David

Keywords: Fecal Microbial Transplantation; Intestinal Microbiome; Metabolites Of The Intestinal Microbiome; Metagenomics Of Intestinal Microbiota; Resistant Atherosclerosis

$321,300

ConCRISPR: Conjugative delivery of a hybrid CRISPR/Tev nuclease system for specific microbiota modulation in the mammalian gut

Principal investigatorCIHR2018Project Grant

Principal investigators: Edgell, David R; Gloor, Gregory B; Karas, Bogumil J

Keywords: Conjugative Plasmid; Crispr/Tevcas9 Nuclese; Designer Nuclease; Microbial Ecosystem Manipulation; Targeted Antimicrobial Therapeutic

$891,226

A DNA printer for gene synthesis and synthetic biology

Co-investigatorNSERC2018Research Tools and Instruments

Principal investigators: Edgell, David

$99,698

Use of Tev-Cas9 dual nucleases to bias genome editing outcomes towards homology directed repair

Co-investigatorCIHR2016Project Grant

Principal investigators: Edgell, David R

Keywords: Crispr/Cas9; Dna Repair; Genome Editing; Homology Directed Repair; I-Tevi Nuclease Domain; Non Homologous End Joining

$86,667

Enhancing CRISPR genome-editing outcomes with the TevCas9 dual nuclease

Co-investigatorCIHR2016Project Grant

Principal investigators: Edgell, David R

Keywords: Crispr/Cas9; Gene Knockouts; Genome Editing; Homology Directed Repair; I-Tevi Homing Endonuclease

$100,000

Evaluating Coevolution in Protein Families

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Gloor, Gregory

$170,000

Intestinal microbiome and extremes of atherosclerosis: 1. TMAO

Co-investigatorCIHR2013Operating Grant

Principal investigators: Spence, J. David

Keywords: Atherosclerosis; Biochemistry; Intestinal Microbiome; Metabonomics; Microbiology; Nutrition; Renal Function; Ultrasound

$211,632

Molecular covariation in protein families

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Gloor, Gregory

$165,000

Functional genomic studies to identify suitable probiotic strain properties

Co-investigatorNSERC2008Collaborative Research and Development Grants

Principal investigators: Reid, Gregor

$42,200

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Emma Allen-Vercoe

Faculty

2 shared papers, latest 2019

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Subject: Prospective PhD student: Conjugative Plasmid Dear Professor Gloor, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Moderate Renal Impairment and Toxic Metabolites Produced by the Intestinal Microbiome: Dietary Implications." (2019), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]