Faculty profile
Michael Boffa
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Research
Read how they describe their research on their Western University profile.
Latest papers
Lipoprotein (a) integrates monocyte-mediated thrombosis and inflammation in atherosclerotic cardiovascular disease.
Journal of lipid research · 2025
Measuring Lp(a) particles with a novel isoform-insensitive immunoassay illustrates efficacy of muvalaplin.
Journal of lipid research · 2025
Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a).
Journal of lipid research · 2020
Latest funding
- $1,028,925
Mechanisms of hepatic biosynthesis and catabolism of lipoprotein(a)
CIHR · 2024 · Co-investigator
- $910,350
Use of a novel transgenic mouse model to probe the molecular mechanisms of lipoprotein(a) pathogenicity in atherosclerosis
CIHR · 2022 · Principal investigator
- $105,000
Use of a novel transgenic mouse model to probe the molecular mechanisms of lipoprotein(a) pathogenicity in atherosclerotic vascular disease
CIHR · 2021 · Supervisor
3 publications.
Lipoprotein (a) integrates monocyte-mediated thrombosis and inflammation in atherosclerotic cardiovascular disease.
Rosenson RS, Tate AM, Grushko OG, Damodaran D, Chen Q, Boffa M, Koschinsky M, Narula J, Goonewardena SN
Measuring Lp(a) particles with a novel isoform-insensitive immunoassay illustrates efficacy of muvalaplin.
Swearingen CA, Sloan JH, Rhodes GM, Siegel RW, Bivi N, Qian Y, Konrad RJ, Boffa M, Koschinsky M, Krege J, Ruotolo G, Nicholls SJ, Michael LF, Wen Y
Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a).
Gonen A, Yang X, Yeang C, Alekseeva E, Koschinsky M, Witztum JL, Boffa M, Tsimikas S
Mechanisms of hepatic biosynthesis and catabolism of lipoprotein(a)
Principal investigators: KOSCHINSKY, Marlys L
Keywords: Cell Biology; Hepatocytes; Lipoprotein Biosynthesis; Lipoprotein Catabolism; Lipoprotein(A); Liver Sinusoidal Endothelial Cells; Protein Structure And Function
Use of a novel transgenic mouse model to probe the molecular mechanisms of lipoprotein(a) pathogenicity in atherosclerosis
Principal investigators: KOSCHINSKY, Marlys L; Boffa, Michael B
Keywords: Atherosclerosis; Inflammation; Lipoprotein(A); Transgenic Mice; Vascular Cells
Use of a novel transgenic mouse model to probe the molecular mechanisms of lipoprotein(a) pathogenicity in atherosclerotic vascular disease
Principal investigators: St. John, Julia M
Keywords: Animal Models; Atherosclerosis; Gene Expression; Histopathology; Immunohistochemistry; Lipoprotein(A); Sc-Rnaseq; Vascular Disease
Development of a Novel Therapy to Prevent Breast Cancer Metastasis: Modulation of TAFI, a Master Regulator of Extracellular Proteolysis
Principal investigators: Boffa, Michael B
Keywords: Breast Cancer; Extracellular Proteolysis; Metastasis; Mouse Models; Thrombin-Activatable Fibrinolysis Inhibitor (Tafi); Thrombomodulin
Apo(a):apoB100 interactions as key determinants of Lp(a) biosynthesis
Principal investigators: KOSCHINSKY, Marlys L
Keywords: Apolipoprotein(A); Apolipoproteinb100; Cardiovascular Disease; Genomics; Hepatocytes; Lipoprotein Secretion; Lipoprotein(A); Pcsk9
Structure, function, and regulation of Thrombin-Activatable Fibrinolysis Inhibitor (TAFI)
Principal investigators: Boffa, Michael
The role of oxidized phospholipids in the pathogenicity of lipoprotein(a)
Principal investigators: KOSCHINSKY, Marlys L
Keywords: Apolipoprotein(A); Atherosclerosis; Cell Signaling; Gene Expression; Inflammation; Lipoprotein(A); Macrophages; Monocytes; Oxidized Phospholipids; Vascular Endothelial Cells
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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