Marie-Claude Sincennes, Institut national de la recherche scientifique

Research

Cancer Genomics Muscle Progenitors Myogenesis Post-Translational Modifications Protein-Protein Interactions Rhabdomyosarcoma Transcription Factors

Latest papers

Transcription Factor Acetylation and Cell Fate Control: A Molecular Switch in Hematopoiesis and Myogenesis.
Frontiers in bioscience (Landmark edition) · 2026 · senior author
Intrinsic Muscle Stem Cell Dysfunction Contributes to Impaired Regeneration in the mdx Mouse.
Journal of cachexia, sarcopenia and muscle · 2025
[Emerging links between metabolism and epigenetic regulation of muscle stem cells].
Medecine sciences : M/S · 2023 · senior author

All 5 publications

Latest funding

Targeting molecular and cellular events that drive tumor formation in rhabdomyosarcoma
CIHR · 2022 · Nominated PI
$100,000

All 1 grants and awards

5 publications.

01

Transcription Factor Acetylation and Cell Fate Control: A Molecular Switch in Hematopoiesis and Myogenesis.

Ghavidel P, Abdelmalki Y, Sincennes MC

Frontiers in bioscience (Landmark edition)2026Senior author

DOI: 10.31083/fbl46704 PMID: 41914295

02

Intrinsic Muscle Stem Cell Dysfunction Contributes to Impaired Regeneration in the mdx Mouse.

Esper ME, Brun CE, Lin AYT, Feige P, Catenacci MJ, Sincennes MC, Ritso M, Rudnicki MA

Journal of cachexia, sarcopenia and muscle2025

DOI: 10.1002/jcsm.13682 PMID: 39723578

03

[Emerging links between metabolism and epigenetic regulation of muscle stem cells].

Leduc-Gaudet JP, Guirguis C, Sincennes MC

Medecine sciences : M/S2023Senior author

DOI: 10.1051/medsci/2023084 PMID: 37387661

04

[GLI3 processing in the primary cilia of muscle stem cells controls their quiescence state].

Sincennes MC, Brun CE

Medecine sciences : M/S2023First author

DOI: 10.1051/medsci/2023040 PMID: 37094263

05

[PAX7 acetylation controls muscle stem cell self-renewal].

Brun CE, Sincennes MC

Medecine sciences : M/S2022Senior author

DOI: 10.1051/medsci/2022073 PMID: 35766845

Targeting molecular and cellular events that drive tumor formation in rhabdomyosarcoma

Nominated PICIHR2022Project Grant - Priority Announcement: Pediatric Cancer Research

Principal investigators: Sincennes, Marie-Claude

Keywords: Cancer; Genomics; Muscle Progenitors; Myogenesis; Post-Translational Modifications; Protein-Protein Interactions; Rhabdomyosarcoma; Transcription Factors; Transcriptomics

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Cancer Dear Professor Sincennes, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Transcription Factor Acetylation and Cell Fate Control: A Molecular Switch in Hematopoiesis and Myogenesis." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Targeting molecular and cellular events that drive tumor formation in rhabdomyosarcoma" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Marie-Claude Sincennes