Stéphane Lefrancois

Research

Biophysics Cln3 Endosomes Intracellular Sorting Lysosomes Retromer Alzheimer'S Disease Amyotrophic Lateral Sclerosis

Latest papers

Phosphorylation on serine 72 modulates Rab7A palmitoylation and retromer recruitment.
Journal of cell science · 2025 · senior author
The Batten disease protein CLN3 is important for stress granules dynamics and translational activity.
The Journal of biological chemistry · 2023
Mechanisms regulating the sorting of soluble lysosomal proteins.
Bioscience reports · 2022 · senior author

All 9 publications

Latest funding

Elucidating the function of CLN3 and CLN5 at endolysosomes
CIHR · 2020 · Nominated PI
$673,200
Systems Analysis of Key Nodes in Neurodegenerative Diseases
CIHR · 2017 · Nominated PI
$499,998
The role of palmitoylation in the trafficking of the lysosomal sorting receptors
CIHR · 2009 · Nominated PI
$508,258

All 3 grants and awards

9 publications.

01

Phosphorylation on serine 72 modulates Rab7A palmitoylation and retromer recruitment.

Modica G, Tejeda-Valencia L, Sauvageau E, Yasa S, Maes J, Skorobogata O, Lefrancois S

Journal of cell science2025Senior author

DOI: 10.1242/jcs.262177 PMID: 39584231

02

The Batten disease protein CLN3 is important for stress granules dynamics and translational activity.

Relton EL, Roth NJ, Yasa S, Kaleem A, Hermey G, Minnis CJ, Mole SE, Shelkovnikova T, Lefrancois S, McCormick PJ, Locker N

The Journal of biological chemistry2023

DOI: 10.1016/j.jbc.2023.104649 PMID: 36965618

03

Mechanisms regulating the sorting of soluble lysosomal proteins.

Meraş İ, Maes J, Lefrancois S

Bioscience reports2022Senior author

DOI: 10.1042/bsr20211856 PMID: 35394021

04

Autophagy in the Neuronal Ceroid Lipofuscinoses (Batten Disease).

Kim WD, Wilson-Smillie MLDM, Thanabalasingam A, Lefrancois S, Cotman SL, Huber RJ

Frontiers in cell and developmental biology2022

DOI: 10.3389/fcell.2022.812728 PMID: 35252181

05

CLN5 and CLN3 function as a complex to regulate endolysosome function.

Yasa S, Sauvageau E, Modica G, Lefrancois S

The Biochemical journal2021Senior author

DOI: 10.1042/bcj20210171 PMID: 34060589

06

Post-translational modifications: How to modulate Rab7 functions.

Modica G, Lefrancois S

Small GTPases2020Senior author

DOI: 10.1080/21541248.2017.1387686 PMID: 29099291

07

CLN3 regulates endosomal function by modulating Rab7A-effector interactions.

Yasa S, Modica G, Sauvageau E, Kaleem A, Hermey G, Lefrancois S

Journal of cell science2020Senior author

DOI: 10.1242/jcs.234047 PMID: 32034082

08

Tumour suppression by blocking palmitoylation.

Lefrancois S

Nature biomedical engineering2019First author

DOI: 10.1038/s41551-019-0383-6 PMID: 30952983

09

Rab7 palmitoylation is required for efficient endosome-to-TGN trafficking.

Modica G, Skorobogata O, Sauvageau E, Vissa A, Yip CM, Kim PK, Wurtele H, Lefrancois S

Journal of cell science2017Senior author

DOI: 10.1242/jcs.199729 PMID: 28600323

Elucidating the function of CLN3 and CLN5 at endolysosomes

Nominated PICIHR2020Project Grant

Principal investigators: Lefrancois, Stéphane

Keywords: Biophysics; Cln3; Endosomes; Intracellular Sorting; Lysosomes; Retromer

$673,200

Systems Analysis of Key Nodes in Neurodegenerative Diseases

Nominated PICIHR2017Operating Grant: Joint Programme on Neurodegenerative Disease Research (JPND)

Principal investigators: Lefrancois, Stéphane; Ernst, Carl P

Keywords: Alzheimer'S Disease; Amyotrophic Lateral Sclerosis; Batten Disease; Biophysics; Cell Biology; Induced Pluripotent Stem Cells; Neurons; Parkinson'S Disease; Protein Homeostasis; Systems Biology

$499,998

The role of palmitoylation in the trafficking of the lysosomal sorting receptors

Nominated PICIHR2009Operating Grant

Principal investigators: Lefrancois, Stéphane

Keywords: Biochemistry; Confocal Microscopy; Lysosomal Trafficking; Neuronal Ceroid Lipofuscinosis; Palmitoylation; Sortilin

$508,258

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Paper to mentionMention their CIHR grant from 2020

Subject: Prospective PhD student: Biophysics Dear Professor Lefrancois, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Phosphorylation on serine 72 modulates Rab7A palmitoylation and retromer recruitment." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Elucidating the function of CLN3 and CLN5 at endolysosomes" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]