Andréa Leblanc, McGill University

Research

Alzheimer Disease Animal Models Biochemistry Caspase-1 Caspase-6 Caspases Cell Biology Inflammation

Latest papers

Proteomic identification of synaptic caspase substrates.
Synapse (New York, N.Y.) · 2018
Synthesis and evaluation of novel dipeptidyl benzoyloxymethyl ketones as caspase inhibitors.
Biochemical and biophysical research communications · 2005

All 2 publications

Latest funding

Validation of the Nlrp1-Casp1-Casp6 pathway as an early therapeutic target of age-dependent cognitive impairment and Alzheimer Disease.
CIHR · 2016 · Nominated PI
$925,650
Role of caspases in human neuronal cell death and in Alzheimer's disease.
CIHR · 2011 · Nominated PI
$781,294
Role of the cytosolic prion protein in the regulation of Bax ubiquitination and its impact on cell survival.
CIHR · 2010 · Supervisor
$105,000

All 5 grants and awards

2 publications.

01

Proteomic identification of synaptic caspase substrates.

Victor KG, Heffron DS, Sokolowski JD, Majumder U, Leblanc A, Mandell JW

Synapse (New York, N.Y.)2018

DOI: 10.1002/syn.22014 PMID: 28960461

02

Synthesis and evaluation of novel dipeptidyl benzoyloxymethyl ketones as caspase inhibitors.

Nedev HN, Klaiman G, LeBlanc A, Saragovi HU

Biochemical and biophysical research communications2005

DOI: 10.1016/j.bbrc.2005.08.098 PMID: 16137654

Validation of the Nlrp1-Casp1-Casp6 pathway as an early therapeutic target of age-dependent cognitive impairment and Alzheimer Disease.

Nominated PICIHR2016Project Grant

Principal investigators: Leblanc, Andréa C

Keywords: Alzheimer Disease; Animal Models; Biochemistry; Caspase-1; Caspase-6; Caspases; Cell Biology; Inflammation; Neurodegeneration

$925,650

Role of caspases in human neuronal cell death and in Alzheimer's disease.

Nominated PICIHR2011Operating Grant

Principal investigators: Leblanc, Andréa C

Keywords: Alzheimer Disease; Animal Models; Caspase-6; Caspases; Gene Expression; Inflammation; Primary Cultures Of Human Neurons; Synaptic Structure And Function

$781,294

Role of the cytosolic prion protein in the regulation of Bax ubiquitination and its impact on cell survival.

SupervisorCIHR2010Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Déry, Marc-André

Keywords: Aging; Apoptosis; Er Stress; Prion Protein; Ubiquitination

$105,000

Regulation of Prion Protein Expression, Trafficking and Function.

Nominated PICIHR2009Operating Grant

Principal investigators: Leblanc, Andréa C

Keywords: Apoptosis; Bax Protein; Cell Death; Prion Protein; Signaling

$689,580

Detection of Tau cleaved by Caspase-6 in the cerebrospinal fluid of individuals with age-related cognitive impairment and Alzheimer disease.

Nominated PICIHR2009Catalyst Grant: Pilot Projects in Aging

Principal investigators: Leblanc, Andréa C

Keywords: Alzheimer Disease; Caspase-6; Cognitive Impairment; Tau; Tau Cleaved By Caspase-6

$49,110

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mention

Subject: Prospective PhD student: Alzheimer Disease Dear Professor Leblanc, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Proteomic identification of synaptic caspase substrates." (2018), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]