Judith Mandl

The mechano-regulation of naive T cell survival: consequences for aging and autoimmunity.

Principal investigators: Mandl, Judith N

Keywords: Aging; Autoimmunity; Calcium Signaling; Cell Death; Cell Migration; Cellular Senscence; Cytoskeleton; Dna Damage; Mechanosensing; T Cell Biology

Is age-related lymphoid fibrosis a driver of naive T cell senescence through mechanically-induced DNA damage?

Principal investigators: Bhagrath, Aanya

Keywords: Cellular Mechanosensing; Confocal Microscopy; Dna Damage; Ferroptosis; Fibrosis; Immunosenescence; Machine Learning Algorithms; Naive T Cells; Nanoindentation; Quantitaive Imaging

Physiological functions of the amyloid precursor protein (APP) in endothelial cells.

Principal investigators: Münter, Lisa M

Keywords: Amyloid Precursor Protein (App); App Knockout Mice; Brain; Cell Culture; Endothelial Cells; Extracellular Matrix; Glucose Transporter; Proteomics, Transcriptomics; Signal Transduction; Stiffness

Diversity in form underlying differences in migratory cell behaviour across innate immune cells within complex environments.

Principal investigators: Mandl, Judith

Keywords: Cell biology; Cell death; Cell migration; CRISPR screen; Microfluidics; Microscopy; Mouse models; Nucleus; Primary immune cells; Tissue microarchitecture

Molecular, cellular, and physiological response to DNA damage, genotoxic stress, and cell death across living systems: RadSource RS-2000 X-ray irradiator

Principal investigators: Nijnik, Anastasia

Controlling cellular and organismal microenvironment using light

Principal investigators: Hayer, Arnold

T cell immunity in tissues: maintaining mobility and adapting to external forces

Principal investigators: Mandl, Judith N

Keywords: Cell Migration; Hippo Pathway; Mechanosensing; Microfluidic Devices; Nuclear Lamina; Piezo1; T Cell Biology; Tissue Resident Memory T Cells

Investigating the role of CYRI/FAM49B in host immunity to intracellular pathogens

Principal investigators: Malo, Danielle; Mandl, Judith N

Keywords: Cytoskeleton; Fam49b/Cyri; Intracellular Bacteria; Mouse Models Of Human Diseases; Myeloid Cells; Rac1; Salmonella; Sepsis

Canada Research Chair - Tier 2

Principal investigators: Mandl, Judith N

Keywords: Crc

Maintaining Cellular and Nuclear Integrity During Immune Cell Migration

Principal investigators: Shen, Connie

Keywords: Cell Trafficking; Cellular Immunity; Cytoskeleton; Immune Cell Migration; Immunodeficiency; Microscopy; Myeloid Cells; Nucleus; Quantitative Imaging; T-Cells