Matthias Götte

5th Canadian Symposium on Hepatitis C Virus: "We're not done yet: Remaining Challenges in HCV"

Principal investigators: Sagan, Selena M

Keywords: Barriers To Care; Disease Burden; Epidemiology; Hepatitis C Virus; National Action Plan; Public Health; Social Sciences; Viral Hepatitis; Virology

Interactions between components of the HCV replication complex

Principal investigators: Götte, Matthias

Keywords: Biochemistry; Fret; Hcv; Replication Complex; Single Molecule Studies; Viral Replication

Molecular mechanisms involved in resistance to different classes of HIV RT inhibitors

Principal investigators: Götte, Matthias

Keywords: Antiretrovirals; Biochemistry; Drug Resistance; Hiv; Reverse Transcriptase

HCV genetic variability and resistance to antiviral drugs

Principal investigators: Götte, Matthias

Keywords: Antiviral Drugs; Biochemical Mechanisms; Drug Resistance; Enzyme Kinetics; Fidelity; Genotype; Hcv Replicons; Hepatitis C Virus (Hcv); Jfh-1; Rna Polymerase

Elucidating Mechanisms of Resistance to HIV-1 Integrase Inhibitors

Principal investigators: Biondi, Mia J

Keywords: Biochemistry; Enzyme Kinetics; Hiv-1; In Silico Studies; Inhibition Studies; Integrase; Pre-Clinical; Protein-Nucleic Acid Interactions; Resistance Mechanisms; Virology

CIHR Team/Emerging Team in Single Molecule Studies on Viral Genome-replication Machinery, Inhibitors and Associated Resistance

Principal investigators: Cosa, Gonzalo; Archambault, Jacques; Götte, Matthias

Keywords: Drug Resistance; Polymerase Inhibitors; Polymerase Mechanism; Protein Conformational Dynamics; Single Molecule Biophysics; Viral Dna And Rna Synthesis

Replacement of floor centrifuge and rotor

Principal investigators: LeMoual, Hervé

Local dissociation of DNA/DNA and DNA/RNA from the ribonuclease H active site of HIV-1 reverse transcriptase: Implications for (+)-strand DNA synthesis and drug design

Principal investigators: Beilhartz, Greg L

Keywords: Drug Development; Drug Resistance; Hiv; Inhibitors; Mechanism; Mutation; Nucleic Acids; Reverse Transcriptase; Rnase H; Virology

CIHR Strategic Training Program in Chemical Biology

Principal investigators: Thomas, David Y

Keywords: Asthma; Biochemistry; Bioinformatics; Biopharmaceutical; Chemical; Chemical Biology; Chemistry; Cystic Fibrosis; Genetics; Infectious Diseases; Pharmacology; Structural Biology

The Role of ATP as an Activator of NcRTI-mediated Inhibition of Reverse Transcription in HIV-1

Principal investigators: Ehteshami Akbari, Maryam

Keywords: Atp; Drug Resistance; Enzyme Kinetics; Fret Assays; Hiv Reverse Transcriptase; Mass Spectrometry; Mutations; Ncrti-1; Ncrtis; Site-Specific Footprinting