Faculty profile
Rebecca Mckinney
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Research
Latest funding
- $1,100,070
Mechanisms underlying common neuronal cell resilience and vulnerability across neurodegenerative diseases
CIHR · 2026 · Nominated PI
- $120,000
Investigating mechanisms underlying common Purkinje cell resilience and vulnerability in rare ataxias
CIHR · 2025 · Supervisor
- $120,000
Investigating mitochondrial dysfunction as the underlying mechanism of patterned Purkinje cell death in the cerebellum of the rare neurological disorder Christianson Syndrome.
CIHR · 2024 · Supervisor
Mechanisms underlying common neuronal cell resilience and vulnerability across neurodegenerative diseases
Principal investigators: Mckinney, Rebecca A; Watt, Alanna
Keywords: Behaviour; Cerebellum; Chemogenetics; Electrophysiology; Imaging; Therapeutics
Investigating mechanisms underlying common Purkinje cell resilience and vulnerability in rare ataxias
Principal investigators: Tourbina-Kolomiets, Julia
Keywords: Arsacs; Ataxia; Cerebellum; Christianson Syndrome; Confocal Microscopy; Electrophysiology; Firing; Purkinje Cell; Scn4b; Viral Injection
Investigating mitochondrial dysfunction as the underlying mechanism of patterned Purkinje cell death in the cerebellum of the rare neurological disorder Christianson Syndrome.
Principal investigators: Kanagasabai, Atchaya
Keywords: Ataxia; Cerebellar Atrophy; Christianson Syndrome; Electron Microscopy; Mitohcondria; Neurodegeneration; Purkinje Cells; Rna Sequencing; Rt-Qpcr; Super-Resolution Confocal Microscopy
How dysfunction of hippocampal sharp wave-ripples leads to cognitive impairment in a mouse model of Christianson syndrome.
Principal investigators: Peyrache, Adrien
Keywords: Genetic Disease; Learning And Memory; Neuronal Dynamics; Sleep
Mechanisms of Endosomal Acid-Base Imbalance linked to Interneuron Circuit Dysfunction in Christianson Syndrome
Principal investigators: Mckinney, Rebecca A
Keywords: Endosomes; Neurotrophins; Receptor Trafficking; Synaptic Plasticity; Transgenic Animals
Pharmacotherapeutic effects of cannabidiol (CBD) in autism spectrum disorder (ASD)
Principal investigators: Sonenberg, Nahum; Aguilar Valles, Argel
Keywords: Autism Spectrum Disorder; Behavior; Cannabinoids; Cell Signalling; Clinical Case Study; Mental Health; Mouse Models; Neuroscience; Pharmcokinetics
Roles of Alkali Cation/Proton Exchangers in Organellar Function and Neurodevelopmental Disorders
Principal investigators: Orlowski, John
Keywords: Alkali Cation/Proton Exchangers; Christianson Syndrome; Fluorescence Microscopy; Gene Cloning And Mutagenesis; Intracellular Ph Regulation; Neuronal Development And Function; Protein Trafficking; Proteomics; Recycling Endosomes; Yeast Two-Hybrid Gene Screening
Support for 2nd International Basic Science and Clinical Conference on Christianson Syndrome
Principal investigators: Orlowski, John
Keywords: Alkali Cation/Proton Exchangers; Christianson Syndrome; Epilepsy; Genetic Mutations; Neurodegeneration; Neurodevelopment; Recycling Endosomes; Slc9a6; X-Linked Intellectual Disability
Molecular mechanisms involved in the stability and modulation of excitatory synapses
Principal investigators: Mckinney, Rebecca A
Keywords: Actin; Animal Behaviour; Barrel Cortex; Calcium; Dendritic Spines; Dynamic Imaging; Electrophysiology; Synapse Maintenance; Synaptic Plasticity; Synaptopodin
Synaptopodin and the remodeling of brain synapses
Principal investigators: Verbich, David
Keywords: Brain; Synapses; Synaptopodin
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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