Terence Hébert

An integrated approach for the discovery and production of novel bioactive agents for neurological and mental health disorders

Principal investigators: Ignea, Codruta

Keywords: Artificial Intelligence; Biological Activity; Biosynthetic Pathways; Gpcrs; Metabolic Engineering; Precision Fermentation; Psychedelics; Synthetic Biology; Yeast

Biased agonism at G-protein coupled receptors: in vitro to in vivo

Principal investigators: Clarke, Paul B; Hébert, Terence E

Keywords: Behavioural Pharmacology; Dopaminergic Receptors; Fibre Photometry; G-Protein Coupled Receptors; In Vivo Biosensors; Intracellular Signalling Pathways; Mu Opioid Receptors

A novel mechanism for GPCR-dependent activation of BRD4

Principal investigators: Tanny, Jason C

Keywords: Brd4; Cardiac Hypertrophy; G-Protein Coupled Receptor; Protein Kinase A; Transcription Elongation

Investigating the role of APJ heterodimers in pain modulation

Principal investigators: Besserer-Offroy, Elie

Keywords: Apelin; Biais Signaling; Cellular Signaling; G Protein-Coupled Receptor; Heterodimerization; Kappa-Opioid; Neurotensin; Pain; Signaling Complexes Formation

The impact of nuclear G protein signalling in health and disease

Principal investigators: Hébert, Terence E

Keywords: Cardiac Fibrosis; Cardiac Hypertrophy; Cellular Signalling; Developmental Disorders; G Proteins; Inducible Pluripotent Stem Cells

Understanding the assembly, trafficking and signalling of G protein-coupled receptor dimers.

Principal investigators: Hébert, Terence E

Keywords: Biosensors; Conformational Profiling; Crispr; Drug Discoveru; G Protein-Coupled Receptors; G Proteins; Proteomics; Receptor Trafficking; Signal Profiling; Signalling Complex Assembly

Development of fiber-optic, fluorescence lifetime-based imaging system for in vivo measures of signalling events

Principal investigators: Hébert, Terence

A study on allosteric modulators and conformational determinants that dictate beta2-adrenergic receptor structure and function.

Principal investigators: Bourque, Kyla

Keywords: Allostery; Beta2-Adrenergic Receptor; Cellular Signaling; Dna Aptamers; Drug Discovery; Flash-Bret; Gpcrs; Ipscs; Nanobodies; Resonance Energy Transfer

Measuring G protein-coupled receptor signaling in vivo with resonance energy-based biosensors

Principal investigators: Jones-Tabah, Jace

Keywords: Behavioral Pharmacology; Biased Agonism/Functional Selectivity; Cell Signalling; Dopamine Receptor Pharmacology; Fiber Photometry; G Protein-Coupled Receptors; In Vivo Imaging

Mechanisms of GnRH action

Principal investigators: Bernard, Daniel J

Keywords: Calcium; Cellular Signaling; Cre/Lox; G Protein Coupled Receptor; Hormones; Mouse Genetics; Neuroendocrinology; Pituitary; Reproduction; Second Messengers