Faculty profile

Wei-Hsiang Huang

ResearcherNeurology and NeurosurgeryMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Wei-Hsiang Huang

Researcher

Neurology and Neurosurgery

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
9 publications in the last five years, latest in 2026.
Senior (last) author on 7 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (6 CIHR, 2 NSERC), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Autism Cortical Organoid Electrophysiology Hipsc-Derived Neuron Induced Pluripotent Stem Cell (Hipsc)Neural Progenitor Cells Single Cell Rna-Sequencing Hipsc-Derived Neuronal Models

Latest papers

CRISPR screening identifies TRIM27 as a destabilizer of the Smith-Magenis syndrome protein RAI1.
Genetics · 2026 · senior author
Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models.
American journal of human genetics · 2025 · senior author
Tunable, proteolytic dosage control of CRISPR-Cas systems enables precise gene therapy for dosage sensitive disorders.
bioRxiv : the preprint server for biology · 2025

All 12 publications

Latest funding

Molecular pathogenesis of Smith-Magenis syndrome and developing therapy using hiPSC-derived neuronal models
CIHR · 2025 · Nominated PI
$30,000
Molecular pathogenesis of Smith-Magenis syndrome and developing therapy using hiPSC-derived neuronal models
CIHR · 2025 · Nominated PI
$1,025,100
Mechanistic investigation of how cortical clonal mutation drives brain-wide developmental defects
CIHR · 2025 · Nominated PI
$150,000

All 9 grants and awards

12 publications.

CRISPR screening identifies TRIM27 as a destabilizer of the Smith-Magenis syndrome protein RAI1.

Lin YC, Lee YJ, Li CX, Chang HC, Kowalczyk M, Haque M, Dragoiescu A, Losier TT, Taylor JA, Rousseaux MWC, Huang WH

Genetics2026Senior author

DOI: 10.1093/genetics/iyag121 PMID: 42140622

Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models.

Lee YJ, Chang YT, Cho Y, Kowalczyk M, Dragoiescu A, Pacis A, Kailasam S, Lefebvre F, Zhang Q, Gao X, Huang WH

American journal of human genetics2025Senior author

DOI: 10.1016/j.ajhg.2025.07.020 PMID: 40882620

Tunable, proteolytic dosage control of CRISPR-Cas systems enables precise gene therapy for dosage sensitive disorders.

Katz N, An C, Lee YJ, Tycko J, Zhang M, Kang J, Bintu L, Bassik MC, Huang WH, Gao XJ

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2024.10.09.617463 PMID: 39416069

TSC2-mTORC1 axis regulates morphogenesis and neurological function of Gli1+ adult-born dentate granule cells.

Kowalczyk M, Lee YJ, Huang WH

Molecular biology of the cell2025Senior author

DOI: 10.1091/mbc.e24-08-0366 PMID: 39602293

Comparative analyses of the Smith-Magenis syndrome protein RAI1 in mice and common marmoset monkeys.

Chang YT, Lee YJ, Haque M, Chang HC, Javed S, Lin YC, Cho Y, Abramovitz J, Chin G, Khamis A, Raja R, Murai KK, Huang WH

The Journal of comparative neurology2024Senior author

DOI: 10.1002/cne.25589 PMID: 38289192

Smith-Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling.

Javed S, Chang YT, Cho Y, Lee YJ, Chang HC, Haque M, Lin YC, Huang WH

eLife2023Senior author

DOI: 10.7554/elife.90333 PMID: 37956053

rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice.

Chang HC, Lee YJ, Javed S, Haque M, Chang YT, Lin YC, Oram C, Huang WH

The Journal of biological chemistry2023Senior author

DOI: 10.1016/j.jbc.2022.102728 PMID: 36410433

Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome.

Chang YT, Kowalczyk M, Fogerson PM, Lee YJ, Haque M, Adams EL, Wang DC, DeNardo LA, Tessier-Lavigne M, Huguenard JR, Luo L, Huang WH

Proceedings of the National Academy of Sciences of the United States of America2022Senior author

DOI: 10.1073/pnas.2210122119 PMID: 36256819

Performing Single-Cell Clonal Analysis in the Mouse Brain Using Mosaic Analysis with Double Markers (MADM).

Huang WH

Methods in molecular biology (Clifton, N.J.)2022First author

DOI: 10.1007/978-1-0716-2409-8_4 PMID: 35776345

Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis syndrome.

Javed S, Lee YJ, Xu J, Huang WH

Human molecular genetics2021Senior author

DOI: 10.1093/hmg/ddab245 PMID: 34463714

Molecular pathogenesis of Smith-Magenis syndrome and developing therapy using hiPSC-derived neuronal models

Nominated PICIHR2025PRIZE - Project Grant - PA: Maud Menten - Biomedical Research

Principal investigators: Huang, Wei-Hsiang

Keywords: Hipsc-Derived Neuronal Models; Molecular Pathogenesis; Smith-Magenis Syndrome

$30,000

Molecular pathogenesis of Smith-Magenis syndrome and developing therapy using hiPSC-derived neuronal models

Nominated PICIHR2025Project Grant

Principal investigators: Huang, Wei-Hsiang

Keywords: Autism; Cortical Organoid; Electrophysiology; Hipsc-Derived Neuron; Induced Pluripotent Stem Cell (Hipsc); Neural Progenitor Cells; Single Cell Rna-Sequencing

$1,025,100

Mechanistic investigation of how cortical clonal mutation drives brain-wide developmental defects

Nominated PICIHR2025Operating Grant: ECRs in Human Development, Child and Youth Health

Principal investigators: Huang, Wei-Hsiang

Keywords: Brain Development; Mosaic Analysis; Neurodevelopmental Disorder; Single-Cell Transcriptomics

$150,000

Molecular pathogenesis of Smith-Magenis syndrome and developing therapy using hiPSC-derived neuronal models

Nominated PICIHR2024Operating Grant - PA: Genetics (Bridge Funding: Research Priorities)

Principal investigators: Huang, Wei-Hsiang

Keywords: Autism; Cortical Organoid; Electrophysiology; Hipsc-Derived Neuron; Induced Pluripotent Stem Cell (Hipsc); Neurodevelopment

$100,000

Creating an integrated platform for in vivo brain targeting and experimentation

Co-investigatorNSERC2023Research Tools and Instruments

Principal investigators: Sabatini, Paul

$149,090

Mechanism and Treatment for Neuronal Hyperexcitability in Smith-Magenis Syndrome

Nominated PICIHR2021Project Grant

Principal investigators: Huang, Wei-Hsiang

Keywords: Genetic Disorders; Ion Channel; Mouse Behavior; Neurodevelopmental Disorders; Neuronal Excitability

$898,876

The role of Retinoic Acid Induced 1 (Rai1) in neural network stability

Principal investigatorNSERC2020Discovery Launch Supplement

Principal investigators: Huang, Wei-Hsiang

$12,500

Determine how somatic gene deletion causes disordered childhood brain development

Nominated PICIHR2020Operating Grant: SickKids-CIHR-IHDCYH New Investigator Grants

Principal investigators: Huang, Wei-Hsiang

Keywords: .

$279,560

The role of Retinoic Acid Induced 1 (Rai1) in neural network stability

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Huang, Wei-Hsiang

$205,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Wei-Hsiang Huang

Research

Latest papers

Latest funding

CRISPR screening identifies TRIM27 as a destabilizer of the Smith-Magenis syndrome protein RAI1.

Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models.

Tunable, proteolytic dosage control of CRISPR-Cas systems enables precise gene therapy for dosage sensitive disorders.

TSC2-mTORC1 axis regulates morphogenesis and neurological function of Gli1+ adult-born dentate granule cells.

Comparative analyses of the Smith-Magenis syndrome protein RAI1 in mice and common marmoset monkeys.

Smith-Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling.

rAAV-CRISPRa therapy corrects Rai1 haploinsufficiency and rescues selective disease features in Smith-Magenis syndrome mice.

Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome.

Performing Single-Cell Clonal Analysis in the Mouse Brain Using Mosaic Analysis with Double Markers (MADM).

Temporal dissection of Rai1 function reveals brain-derived neurotrophic factor as a potential therapeutic target for Smith-Magenis syndrome.

Molecular pathogenesis of Smith-Magenis syndrome and developing therapy using hiPSC-derived neuronal models

Molecular pathogenesis of Smith-Magenis syndrome and developing therapy using hiPSC-derived neuronal models

Mechanistic investigation of how cortical clonal mutation drives brain-wide developmental defects

Molecular pathogenesis of Smith-Magenis syndrome and developing therapy using hiPSC-derived neuronal models

Creating an integrated platform for in vivo brain targeting and experimentation

Mechanism and Treatment for Neuronal Hyperexcitability in Smith-Magenis Syndrome

The role of Retinoic Acid Induced 1 (Rai1) in neural network stability

Determine how somatic gene deletion causes disordered childhood brain development

The role of Retinoic Acid Induced 1 (Rai1) in neural network stability

Frequent collaborators

Qihuang Zhang