Christian Landry

The molecular bases of dominant negative mutations

Principal investigators: Landry, Christian

Keywords: Deep Mutational Scanning; Disease Mutations; Dominant Negative Mutations; Homomeric Proteins; Loss Of Function Mutations; Metabolic Enzymes; Protein-Protein Interactions; Variant Predictors

Integrating the AntiMicrobio-Résistance-Québec Network (AMRQ) to a Pan-Canadian framework for AMR research and action

Principal investigators: Nguyen, Dao; Ouellette, Marc

Keywords: Antimicrobial Resistance; Collaboration; Mobilization; One Health; Public Health; Research Network

Genetic dissection of an entire protein interactome at the resolution of individual amino acids

Principal investigators: Landry, Christian

Keywords: Deep Mutational Scanning; Disordered Proteins; Endocytosis; Genome Editing; High-Throughput Screening; Protein-Protein Interaction Network; Sh3 Domains; Short Linear Motifs; Systems Biology Of Mutations; Variant Predictors

Deep mutational scanning for collateral sensitivity of antifungal drug resistance

Principal investigators: Carolus, Hans

Keywords: Antifungal Drug Resistance,; Antifungal Drugs; Antimicrobials And Resistance; Candida Auris; Collateral Sensitivity; Deep Mutational Scanning; Echinocandins; Fungi; Modelling; Molecular Genetics

Fungal AMR saturation base editing (FASBE) for enabling machine learning-guided infection treatment and prognostic in clinical settings

Principal investigators: Landry, Christian

Keywords: Antifungal Resistance; Base Editing; Fungal Pathogens; Genome Editing; High-Throughput Screening; Machine Learning; Precision Medicine; Variants Of Concern

Canadian One Health Antimicrobial Resistance Health Research Training Network (CAN-AMR-Net)

Principal investigators: Barkema, Herman W; Cheng, Zhenyu; Lee, Amy H; Nguyen, Dao; Otto, Simon J; Wiktorowicz, Mary E

Keywords: Antimicrobial Resistance; Collaboration; Communication; Education; Employment Readiness; Experience; Highly-Qualified Personnel; Knowledge Transfer; One Health; Transdisciplinary

Quantifying the genomic sources of evolutionary innovations through integrative biology

Principal investigators: Landry, Christian

Canada Research Chairs - Tier 1

Principal investigators: Landry, Christian

Keywords: Crc

A systems biology approach to understand the determinants of protein robustness to mutation

Principal investigators: Després, Philippe

Keywords: Bioinformatics; Biological Networks; Crispr-Cas9; Genetics; Genome Editing; High Throughput; Mutations; Personalized Medicine; Protein-Protein Interactions; Systems Biology

GOTlib : systematic identification of CRISPR/Cas9 targets in genomic data

Principal investigators: Després, Philippe

Keywords: Bioinformatics; Crispr/Cas9; Gecko Experiments; Genome-Wide; Non-Model Species; Pathogenic Yeasts; Systems Biology