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Research
Latest papers
Assessing Ecto-5'-Nucleotidase/CD73 Expression and Malignancy Parameters in Early- and Late- Passage C6 Glioma Cells.
Neurochemical research · 2025
Neutrophils: fast and furious-the nucleotide pathway.
Purinergic signalling · 2021
Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5'-Nucleotidase Inhibitors.
ACS medicinal chemistry letters · 2020
Latest funding
- $120,000
P2Y6 antagonists as a potential therapy for inflammatory bowel disease
CIHR · 2025 · Supervisor
- $80,000
Ectonucleotidases and Extracellular Nucleotides in Smooth Muscle Cell Contraction
NSERC · 2023 · Principal investigator
- $883,576
A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease
CIHR · 2021 · Nominated PI
4 publications.
Assessing Ecto-5'-Nucleotidase/CD73 Expression and Malignancy Parameters in Early- and Late- Passage C6 Glioma Cells.
Manica FM, Campesato LFI, Scholl JN, Braganhol E, Bergamin LS, Edelweiss MIA, Lenz G, Sevigny J, Figueiró F, Battastini AMO
Neutrophils: fast and furious-the nucleotide pathway.
Rubenich DS, de Souza PO, Omizzollo N, Lenz GS, Sevigny J, Braganhol E
Synthesis, Characterization, and In Silico Studies of Novel Spirooxindole Derivatives as Ecto-5'-Nucleotidase Inhibitors.
Ashraf A, Shafiq Z, Khan Jadoon MS, Tahir MN, Pelletier J, Sevigny J, Yaqub M, Iqbal J
Synthesis and computational studies of highly selective inhibitors of human recombinant tissue non-specific alkaline phosphatase (h-TNAP): A therapeutic target against vascular calcification.
Andleeb H, Hussain M, Abida Ejaz S, Sevigny J, Farman M, Yasinzai M, Zhang J, Iqbal J, Hameed S
P2Y6 antagonists as a potential therapy for inflammatory bowel disease
Principal investigators: guedes manzoni, alessandra
Keywords: Antagonists; Crohn'S Disease; Inflammation; Inflammatory Bowel Disease; P2 Receptor; Ulcerative Colitis
Ectonucleotidases and Extracellular Nucleotides in Smooth Muscle Cell Contraction
Principal investigators: Sévigny, Jean
Keywords: ADP; ATP; contraction; ecto-ATPase; ecto-nucleotidase; NTPDase1; P2 receptors; smooth muscle cells; UDP; UTP
A recombinant soluble NTPDase8 as a novel biological treatment for inflammatory bowel disease
Principal investigators: Sevigny, Jean; Salesse, Christian
Keywords: Computational Biophysics; Enzyme Engineering; Extracellular Nucleotides; Ibd Models; Inflammatory Bowel Disease; Mouse Models; P2 Receptors; Protein Overexpression; Udp, Utp, Adp, Atp
A novel approach to treating inflammatory bowel diseases through the blocking of P2Y6 receptors
Principal investigators: Sevigny, Jean
Keywords: Extracellular Nucleotides; Ibd Models; Inflammatory Bowel Diseases; P2 Receptors; Udp; Utp
Role of NTPDase1 and Extracellular Nucleotides in Smooth Muscle Cell Contraction
Principal investigators: Sévigny, Jean
Role of NTPDase1 and extracellular nucleotides in smooth muscle cell contraction
Principal investigators: Sévigny, Jean
Characterization and Roles of Hepatic Ectonucleotidases
Principal investigators: Sevigny, Jean
Keywords: Animal Models; Apyrase; Cholestasis; Cirrhosis; Immunohistochemistry; Nucleotidases
Modulation de la pression artérielle par la NTPDase1 et les nucléotides extracellulaires
Principal investigators: Sevigny, Jean
Keywords: Atp/Adp/Utp/Udp; Ectonucléotidase/Ntpdase1/Cd39; Nucléotides Extracellulaires; Récepteurs P2y; Tonus Vasculaire
Extracellular nucleotides in inflammatory cell reactions to pathogenic determinants
Principal investigators: Sevigny, Jean
Keywords: Animal Model; Apyrase; Arthritis; Biochemistry; Cd39; Cell Biology
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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