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Research
Latest papers
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.
Brain : a journal of neurology · 2018
Latest funding
- $1,032,750
Neuroprotective peptides for treatment of neurological lysosomal diseases
CIHR · 2021 · Nominated PI
- $100,000
Neuroprotective peptides for treatment of neurological lysosomal diseases
CIHR · 2020 · Nominated PI
- $715,275
Novel Treatments for Lysosomal Neurological Disorders: Targeting Microglia Cells and Misfolded Proteins for Therapy of Mucopolysaccharidosis IIIC
CIHR · 2017 · Nominated PI
1 publications.
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.
Tordo J, O'Leary C, Antunes ASLM, Palomar N, Aldrin-Kirk P, Basche M, Bennett A, D'Souza Z, Gleitz H, Godwin A, Holley RJ, Parker H, Liao AY, Rouse P, Youshani AS, Dridi L, Martins C, Levade T, Stacey KB, Davis DM, Dyer A, Clément N, Björklund T, Ali RR, Agbandje-McKenna M, Rahim AA, Pshezhetsky A, Waddington SN, Linden RM, Bigger BW, Henckaerts E
Neuroprotective peptides for treatment of neurological lysosomal diseases
Principal investigators: Pshezhetsky, Alexey V
Keywords: Acth; Bdnf; Gene-Targeted Mouse Models; Heparan Sulfate; Lysosomal Storage Diseases; Mri; Mucopolysaccharidosis; Neurodegeneration; Neuroprotection; Synaptic Transmission
Neuroprotective peptides for treatment of neurological lysosomal diseases
Principal investigators: Pshezhetsky, Alexey V
Keywords: Acth; Bdnf; Gene-Targeted Mouse Models; Heparan Sulfate; Lysosomal Storage Diseases; Mri; Mucopolysaccharidosis; Neurodegeneration; Neuroprotection; Synaptic Transmission
Novel Treatments for Lysosomal Neurological Disorders: Targeting Microglia Cells and Misfolded Proteins for Therapy of Mucopolysaccharidosis IIIC
Principal investigators: Pshezhetsky, Alexey V
Keywords: Heparan Sulfate; Lysosomal Storage Disorders; Lysosome; Microglial Cell; Missense Mutations; Molecular Chaperones; Mucopolysaccharidosis
Novel Treatments for Lysosomal Neurological Disorders: Targeting Microglia Cells and Missfolded Proteins for Therapy of Mucopolysaccharidosis IIIC
Principal investigators: Pshezhetsky, Alexey V
Keywords: Heparan Sulfate; Lysosomal Storage Disease; Lysosome; Microglial Cell; Missense Mutations; Molecular Chaperones; Mucopolysaccharidosis
Neuraminidase 1 as a trigger of immune thrombocytopenia: using animal models to understand pathophysiology of the disease and develop novel therapies.
Principal investigators: Pshezhetsky, Alexey V
Keywords: Lysosome; Macrophage; Neuraminidase; Platelet; Sialidase; Thrombocytopenia
Mucopolysaccharidosis IIIC as a protein folding disease: using animal models to study pathophysiology and explore potential therapeutic solutions
Principal investigators: Pshezhetsky, Alexey V
Keywords: Animal Models; Enzyme Refolding Therapy; Lysosomal Storage Disease; Lysosome; Molecular Chaperons; Mucopolysaccharidosis; Mutation Analysis
Serine carboxypeptidases that inactivate short vasoactive peptides: roles in vasoconstriction and proliferation of vascular SMCs
Principal investigators: Pshezhetsky, Alexey V
Keywords: Angiotensin; Carboxypeptidases; Cathepsin A; Endothelin; Remodelling; Smooth Muscle Cells; Transgenic Mice; Vascular Peptides
Carboxypeptidases that inactivate short vasoactive peptides: roles in vasoconstriction and proliferation of vascular SMCs
Principal investigators: Pshezhetsky, Alexey V
Keywords: Angiotensin; Carboxypeptidases; Cathepsin A; Endothelin; Remodelling; Smooth Muscle Cells; Transgenic Mice; Vascular Peptides
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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