El Affar

Rôle de la signalisation à l'ubiquitine dans la mitose

Principal investigators: Traoré, Farid Abdoul Nour

Keywords: Cellule; Cellules Filles; Chromosome; Mitose

A histology suite for visualizing cell distribution in tissues

Principal investigators: Lesage, Sylvie

Keywords: Cellular positioning; Fluorecent microscopy; Histology; Microscopy; Tissue sections

Investigating Novel Mechanisms of Epigenetic Regulation by the BAP1-ASXL Protein Complexes.

Principal investigators: Affar, El Bachir

Keywords: Cancer; Cell Signaling; Chromatin; Epigenetics; Methylation; Mouse Genetics; O-Glcnacylation; Post-Translational Modifications; Transcription; Ubiquitination

Investigating a novel immunomodulatory molecule in checkpoint inhibition of T cells

Principal investigators: Melichar, Heather

Keywords: B1 Cells; Co-Signaling Molecules; Infection; Protein-Protein Interaction Screen; T Cells; Tumor Necrosis Factor Receptor; Tumors; Vaccination

Novel regulatory mechanisms of the mammalian nuclear proteasome through liquid-liquid phase separation

Principal investigators: Affar, El Bachir

Keywords: Cell Death; Cell Metabolism; Cell Signaling; Deubiquitination; Llps; Nuclear Bodies; Phase Separation; Proteasome; Protein Degradation; Ubiquitin

Influence of Ikaros on treatment response in Acute Lymphoblastic Leukemia

Principal investigators: Milot, Eric

Keywords: Acute Lymphoblastic Leukemia; Dna-Rna Hybrids; Genomic Instability; Ikaros; Protein Interactome; R-Chip-Seq

Novel mechanisms of ubiquitin signaling coordinating ribosome maturation and function

Principal investigators: Affar, El Bachir

Novel ubiquitin signaling pathways regulating ASXL family of transcription co-factors

Principal investigators: Affar, El Bachir

Keywords: Cell Proliferation; Chromatin; Deubiquitinase; Epigenomic; Post-Translational Modifications; Rnai; Senescence; Transcription Regulation; Ubiquitin Ligase; Ubiquitin Signaling

A Benchtop Cell Sorter for Accelerating the Discovery of Physiopathological Processes

Principal investigators: Milot, ERIC

A microcalorimetry system to define the biochemical parameters of molecular interactions

Principal investigators: Affar, ElBachir