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Research
Latest papers
Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion.
Biology · 2023
Ostm1 from Mouse to Human: Insights into Osteoclast Maturation.
International journal of molecular sciences · 2020 · first author
TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion.
Proceedings of the National Academy of Sciences of the United States of America · 2019
Latest funding
- $734,372
Molecular analysis of osteopetrosis
CIHR · 2015 · Nominated PI
- $710,841
Characterization of the Role of Inpp4 in Bone Physiology
CIHR · 2012 · Nominated PI
- $822,085
Molecular Analysis of Osteopetrosis
CIHR · 2009 · Nominated PI
11 publications.
Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion.
Shen S, Si M, Zeng C, Liu EK, Chen Y, Vacher J, Zhao H, Mohan S, Xing W
Ostm1 from Mouse to Human: Insights into Osteoclast Maturation.
Vacher J, Bruccoleri M, Pata M
TLR1/2 ligand enhances antitumor efficacy of CTLA-4 blockade by increasing intratumoral Treg depletion.
Sharma N, Vacher J, Allison JP
Distinct roles of arginases 1 and 2 in diabetic nephropathy.
Morris SM, You H, Gao T, Vacher J, Cooper TK, Awad AS
Cre/lox Studies Identify Resident Macrophages as the Major Source of Circulating Coagulation Factor XIII-A.
Beckers CML, Simpson KR, Griffin KJ, Brown JM, Cheah LT, Smith KA, Vacher J, Cordell PA, Kearney MT, Grant PJ, Pease RJ
Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.
Pandruvada SN, Beauregard J, Benjannet S, Pata M, Lazure C, Seidah NG, Vacher J
Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis.
Chang J, Vacher J, Yao B, Fan X, Zhang B, Harris RC, Zhang MZ
Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury.
Awad AS, You H, Gao T, Cooper TK, Nedospasov SA, Vacher J, Wilkinson PF, Farrell FX, Brian Reeves W
Use of a novel floxed mouse to characterise the cellular source of plasma coagulation FXIII-A.
Griffin K, Simpson K, Beckers C, Brown J, Vacher J, Ouwehand W, Alexander W, Pease R, Grant P
Inpp4b is a novel negative modulator of osteoclast differentiation and a prognostic locus for human osteoporosis.
Vacher J
Molecular analysis of osteopetrosis
Principal investigators: Vacher, Jean
Keywords: Genetics; Molecular And Cellular Biology; Musculo Skeletal System And Rehabilitation
Characterization of the Role of Inpp4 in Bone Physiology
Principal investigators: Vacher, Jean
Keywords: Bone Homeostasis; Bone Mineral Density; Inositol Phosphatase; Molecular Biology; Osteoclast Differentiation And Activation; Osteopetrosis; Osteoporosis
Molecular Analysis of Osteopetrosis
Principal investigators: Vacher, Jean
Keywords: Bone Homeostasis; Hematopoiesis; Mouse Genetics; Osteoclast; Osteopetrosis/Osteoporosis
Characterization of the Role of Inpp4b in Bone Physiology
Principal investigators: Vacher, Jean
Keywords: Bone Homeostasis; Bone Mineral Density; Inositol Phosphatase; Molecular Biology; Osteoclast Differentiation And Activation; Osteopetrosis; Osteoporosis
Expression and functional analyses of the mouse glas-1 gene
Principal investigators: Vacher, Jean
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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