John Pascal

Defining and targeting the eraser functions of Poly(ADP-ribose) Glycohydrolase (PARG) in PAR-DNA hybrids and DNA double-strand break repair

Principal investigators: Masson, Jean-Yves

Keywords: Dna Adp-Ribosylation; Dna Damage Response; Dna Double-Strand Break Repair; Dna End Resection; Glycohydrolase; Homologous Recombination; Parg; Poly(Adp-Ribose)

Structural biology and biochemistry of PARP enzyme regulation in the DNA damage response and in cancer therapy

Principal investigators: Pascal, John M

Keywords: Dna Damage Repair; Enzyme Regulation; Genome Maintenance; Parp Inhibitors; Poly(Adp-Ribose); Poly(Adp-Ribose) Polymerase, Parp; Structural Biology; X-Ray Crystallography

Photon III X-ray detector for metal jet diffractometer

Principal investigators: Schaper, Frank

Macromolecular interaction analysis using a surface plasmon resonance biosensor

Principal investigators: Pascal, John

A versatile broad range microscale thermophoresis apparatus for the measurement of biomolecular interactions

Principal investigators: Najmanovich, Rafael

Structural Biology of Tankyrase Activity and Regulation in Cell Signaling

Principal investigators: Pascal, John M

Keywords: Biochemistry; Cell Signaling; Enzyme Regulation; Poly(Adp-Ribose) Polymerases (Parps); Protein-Protein Interactions; Small-Angle X-Ray Scattering (Saxs); Structural Biology; Tankyrase; X-Ray Crystallography

Structural Biochemistry of Coordinated DNA Damage Repair Pathways

Principal investigators: Pascal, JohnMatteson

Structural Biology of DNA Damage-Dependent PARPs

Principal investigators: Pascal, John M

Keywords: Biochemistry; Dna Binding; Dna Damage Response; Dna Repair; Enzyme Allostery; High-Throughput Assay Development; Poly(Adp-Ribose) Polymerase; Structural Biology; X-Ray Crystallography