Jurgen Sygusch, Université de Montréal

Latest papers

A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa.
Structure (London, England : 1993) · 2021 · senior author
Targeting a moonlighting function of aldolase induces apoptosis in cancer cells.
Cell death & disease · 2019
Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases.
The Journal of biological chemistry · 2018 · senior author

All 7 publications

Latest funding

Structural investigation of reaction intermediates in glycolytic aldolases
NSERC · 2016 · Principal investigator
$198,000
Robot for lipidic cubic phase (LCP) crystallization of membrane proteins
NSERC · 2015 · Co-investigator
$143,943
Low-volume ITC for investigating biomolecular interactions
NSERC · 2012 · Co-investigator
$130,099

All 15 grants and awards

7 publications.

01

A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa.

Fabre L, Ntreh AT, Yazidi A, Leus IV, Weeks JW, Bhattacharyya S, Ruickoldt J, Rouiller I, Zgurskaya HI, Sygusch J

Structure (London, England : 1993)2021Senior author

DOI: 10.1016/j.str.2020.09.001 PMID: 32966762

02

Targeting a moonlighting function of aldolase induces apoptosis in cancer cells.

Gizak A, Wiśniewski J, Heron P, Mamczur P, Sygusch J, Rakus D

Cell death & disease2019

DOI: 10.1038/s41419-019-1968-4 PMID: 31558701

03

Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases.

Jacques B, Coinçon M, Sygusch J

The Journal of biological chemistry2018Senior author

DOI: 10.1074/jbc.ra117.001098 PMID: 29593097

04

Isomer activation controls stereospecificity of class I fructose-1,6-bisphosphate aldolases.

Heron PW, Sygusch J

The Journal of biological chemistry2017Senior author

DOI: 10.1074/jbc.m117.811034 PMID: 28972169

05

Peptides designed to spatially depict the Epstein-Barr virus major virion glycoprotein gp350 neutralization epitope elicit antibodies that block virus-neutralizing antibody 72A1 interaction with the native gp350 molecule.

Tanner JE, Coinçon M, Leblond V, Hu J, Fang JM, Sygusch J, Alfieri C

Journal of virology2015

DOI: 10.1128/jvi.03269-14 PMID: 25694592

06

Crystal structures of DNA-Whirly complexes and their role in Arabidopsis organelle genome repair.

Cappadocia L, Maréchal A, Parent JS, Lepage E, Sygusch J, Brisson N

The Plant cell2010

DOI: 10.1105/tpc.109.071399 PMID: 20551348

07

A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein.

St-Jean M, Izard T, Sygusch J

The Journal of biological chemistry2007Senior author

DOI: 10.1074/jbc.m611505200 PMID: 17329259

Structural investigation of reaction intermediates in glycolytic aldolases

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Sygusch, Jurgen

$198,000

Robot for lipidic cubic phase (LCP) crystallization of membrane proteins

Co-investigatorNSERC2015Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Baron, Christian

$143,943

Low-volume ITC for investigating biomolecular interactions

Co-investigatorNSERC2012Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Omichinski, James

$130,099

Macromolecular crystallization facility

Principal investigatorNSERC2010Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Sygusch, Jurgen

$149,884

Structural investigation of reaction intermediates in glycolytic aldolases

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Sygusch, Jurgen

$200,000

NSERC CREATE Training Program in Cellular dynamics of macromolelecular complexes

Co-investigatorNSERC2010Collaborative Research and Training Experience

Principal investigators: Baron, Christian

$1,600,000

Investigations of biomolecules by florescence spectroscopy

Co-investigatorNSERC2010Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Omichinski, James

$65,502

Consortium for the operation of protein crystallographic microfocus synchrotron beamline

Principal investigatorNSERC2009Major Resources Support Program - Infrastructure

Principal investigators: Sygusch, Jurgen

$41,200

Investigations of biomolecular interactions by isothermal titration calorimetry

Co-investigatorNSERC2007Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Omichinski, James

$124,618

Consortium for operation of a protein crystallographic synchrotron beamline

Principal investigatorNSERC2006Major Facilities Access Grants

Principal investigators: Sygusch, Jurgen

$348,750

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Jing Hu

Philosophy

1 shared papers, latest 2015

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Subject: Prospective PhD student Dear Professor Sygusch, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa." (2021), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]