Faculty profile
Matthew Smith
Back to facultyThis profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Université de Montréal directory, so their courses and email address may be missing. Find their university profile.
Latest papers
Phase III Study of Cabozantinib in Previously Treated Metastatic Castration-Resistant Prostate Cancer: COMET-1.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016 · first author
Pathologic fractures correlate with reduced survival in patients with malignant bone disease.
Cancer · 2007
Latest funding
- $120,000
Biophysics of RAB GTPases at the Interface of Human Disease
CIHR · 2025 · Supervisor
- $826,200
Regulation of RAS driven cellular proliferation by SHOC2 and the MRAS GTPase
CIHR · 2023 · Nominated PI
- $956,250
Development and preclinical validation of first-in-class dual inhibitors of the atypical MAP kinases ERK3 and ERK4
CIHR · 2022 · Co-investigator
2 publications.
Phase III Study of Cabozantinib in Previously Treated Metastatic Castration-Resistant Prostate Cancer: COMET-1.
Smith M, De Bono J, Sternberg C, Le Moulec S, Oudard S, De Giorgi U, Krainer M, Bergman A, Hoelzer W, De Wit R, Bögemann M, Saad F, Cruciani G, Thiery-Vuillemin A, Feyerabend S, Miller K, Houédé N, Hussain S, Lam E, Polikoff J, Stenzl A, Mainwaring P, Ramies D, Hessel C, Weitzman A, Fizazi K
Pathologic fractures correlate with reduced survival in patients with malignant bone disease.
Saad F, Lipton A, Cook R, Chen YM, Smith M, Coleman R
Biophysics of RAB GTPases at the Interface of Human Disease
Principal investigators: Decorso, Isabelle
Keywords: Cancer Biology; Cryo-Em; Membrane Trafficking; Nanodiscs; Neurodegeneration; Nmr; Protein-Lipid Interactions; Rab Gtpase Regulation; Signalling Pathways; Structural Biology
Regulation of RAS driven cellular proliferation by SHOC2 and the MRAS GTPase
Principal investigators: Smith, Matthew J
Keywords: Bret Assay; Mapk Pathway; Nmr Spectroscopy; Protein Biophysics; Ras Gtpase; Shoc2; Signal Transduction; X-Ray Crystallography
Development and preclinical validation of first-in-class dual inhibitors of the atypical MAP kinases ERK3 and ERK4
Principal investigators: Meloche, Sylvain
Keywords: Cadd; Chemical Biology; Chemical Screens; Drug Development; Erk3/Erk4; Hit-To-Lead Chemistry; Map Kinases; Pharmacology; Preclinical Evaluation; Signal Transduction
Regulation of cytokinesis by the novel and conserved flavin-dependent monooxygenase enzymes OSGN-1/OSGIN
Principal investigators: Labbe, Jean-Claude
Keywords: Actomyosin Contractility; Biochemical Assays; Cell Division; Cytokinesis And Abscission; Fundamental Cell Biology; Imaging And Image Analysis; Intracellular Signalling; Molecular Genetics; Oxidation; Small Rho Gtpases
Development and preclinical validation of first-in-class dual inhibitors of the atypical MAP kinases ERK3 and ERK4
Principal investigators: Meloche, Sylvain
Keywords: Chemical Biology; Drug Development; Erk3/Erk4; Hit-To-Lead Chemistry; Map Kinases; Pharmacology; Preclinical Evaluation; Signal Transduction; Structural Biology; Synthetic Lethality
Investigation into RAS GTPase control of cell adhesion and proliferation through alternative downstream effectors
Principal investigators: Smith, Matthew J
Keywords: Adhesion; Afdn (Afadin); Cryo-Em; Effectors; Hippo; Metastasis; Ras; Rassf; Rewiring; Tumour Suppressors
Systematic mapping of the global ARF network interactome by BioID coupled to functional studies to reveal novel biological functions
Principal investigators: Côté, Jean-François
Keywords: Arf Gtpases; Effector Proteins; Fly Genetics; Ras Gtpases; Signal Transduction; Structural Biology; Trafficking
Canada Research Chair - Tier 2
Principal investigators: Smith, Matthew J
Keywords: Crc
Development of nanoscale device arrays to investigate the biophysical properties of fundamental cellular switch proteins
Principal investigators: Smith, Matthew
Keywords: nanodevices, multichannel, conductance, protein, biophysics, GTPase, effector, graphene, systems biology, biochemistry
Atomic-level visualization of signalling protein activity in living mammalian cells using In-Cell NMR spectroscopy
Principal investigators: Smith, Matthew
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.