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Research
Latest papers
Increased excitability of dentate gyrus mossy cells occurs early in life in the Tg2576 model of Alzheimer's disease.
Alzheimer's research & therapy · 2025
Reelin-Related Disturbances in Depression: Implications for Translational Studies.
Frontiers in cellular neuroscience · 2016
Latest funding
- $1,239,300
Advancing CB1R Cannabinoid Receptor Positive Allosteric Modulators for Novel Therapies in Temporal Lobe Epilepsy
CIHR · 2026 · Principal investigator
- $149,703
A modern electrophysiology system for whole cell patch clamp recordings, extracellular field recordings, and optogenetic manipulations in rodent brain slices.
NSERC · 2025 · Principal investigator
- $120,000
Controlling epileptiform activity through a supramammillary-hippocampal circuit in a mouse model of epilepsy
CIHR · 2025 · Supervisor
2 publications.
Increased excitability of dentate gyrus mossy cells occurs early in life in the Tg2576 model of Alzheimer's disease.
Alcantara-Gonzalez D, Kennedy M, Criscuolo C, Botterill J, Scharfman HE
Reelin-Related Disturbances in Depression: Implications for Translational Studies.
Caruncho HJ, Brymer K, Romay-Tallón R, Mitchell MA, Rivera-Baltanás T, Botterill J, Olivares JM, Kalynchuk LE
Advancing CB1R Cannabinoid Receptor Positive Allosteric Modulators for Novel Therapies in Temporal Lobe Epilepsy
Principal investigators: Laprairie, Robert B; Botterill, Justin J; Thakur, Ganesh A
Keywords: Allosteric Modulation; Cannabinoid; Drug Discovery; Epilepsy; Molecular Biology; Neuroscience; Pharmacology; Structure-Activity Relationships; Type 1 Cannabinoid Receptor
A modern electrophysiology system for whole cell patch clamp recordings, extracellular field recordings, and optogenetic manipulations in rodent brain slices.
Principal investigators: Botterill, Justin
Keywords: neuroscience; electrophysiology; whole-cell patch clamp recordings; adeno-associated viruses; optogenetics; local field recordings; microscope; mice; pharmacology
Controlling epileptiform activity through a supramammillary-hippocampal circuit in a mouse model of epilepsy
Principal investigators: Trofimova, Alina
Keywords: Brain Activity Monitoring; Electrophysiology; Epilepsy; Fiber Photometry; Hippocampus; Hypothalamus; Mouse Models Of Epilepsy; Neuronal Excitability; Neurophysiology; Optogenetics
A dentate gyrus circuit that regulates novelty, cognition, and affective behaviours
Principal investigators: Botterill, Justin
Keywords: Adeno-associated virus; Behavioural neuroscience; Electrophysiology; Hippocampus; In vivo recordings; Long-term potentiation; Mossy cell; Neuronatomy; Optogenetics; Stereotaxic surgery
A dentate gyrus circuit that regulates novelty, cognition, and affective behaviours
Principal investigators: Botterill, Justin
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
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