Faculty profile

Linda Chelico

ResearcherBiochemistry, Microbiology & ImmunologyUniversity of Saskatchewan

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Saskatchewan directory, so their courses may be missing. Find their university profile.

Linda Chelico

Researcher

Biochemistry, Microbiology & Immunology

Health Sciences

University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
13 publications in the last five years, latest in 2026.
Senior (last) author on 7 recent papers, a sign of leading a research group.
Principal investigator on 12 research grants (10 CIHR, 2 NSERC), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Protein-Protein Interactions Deaminase Cell Transformation Dna Replication Mouse Xenograft Model Protein-Dna Interactions Somatic Mutagenesis Chromosomal Instability

Latest papers

Both Domains of APOBEC3F Recognize AA RNA Motifs to Support HIV-1 Virion Encapsidation and Antiviral Function.
Journal of molecular biology · 2026
Differential effects on tumor progression by APOBEC3A, APOBEC3B, and APOBEC3H Haplotype I in a breast cancer mouse xenograft model.
Frontiers in genetics · 2025 · senior author
APOBEC3A-Induced DNA Damage Drives Polymerase θ Dependency and Synthetic Lethality in Cancer.
bioRxiv : the preprint server for biology · 2025

All 51 publications

Latest funding

Role of APOBEC3 single-stranded DNA cytosine deaminases in breast cancer
CIHR · 2025 · Nominated PI
$1,029,202
Role of APOBEC3 single-stranded DNA cytosine deaminases in breast cancer
CIHR · 2024 · Nominated PI
$100,000
Role of APOBEC3 single-stranded DNA cytosine deaminases in breast cancer
CIHR · 2024 · Nominated PI
$100,000

All 15 grants and awards

51 publications.

Both Domains of APOBEC3F Recognize AA RNA Motifs to Support HIV-1 Virion Encapsidation and Antiviral Function.

Pacheco J, Yousefi M, Yang H, Li S, Chelico L, Chen XS

Journal of molecular biology2026

DOI: 10.1016/j.jmb.2025.169536 PMID: 41207371

Differential effects on tumor progression by APOBEC3A, APOBEC3B, and APOBEC3H Haplotype I in a breast cancer mouse xenograft model.

Granadillo Rodríguez M, Wong L, Shayeganmehr A, Pellegrina D, Vizeacoumar FS, Vizeacoumar FJ, Helmy M, Chelico L

Frontiers in genetics2025Senior author

DOI: 10.3389/fgene.2025.1425483 PMID: 41675410

APOBEC3A-Induced DNA Damage Drives Polymerase θ Dependency and Synthetic Lethality in Cancer.

Bose A, Liu W, Yoo P, Sami A, Boniecki MT, Deshpande M, Osman M, Nguyen D, Castillo UD, Giannakakou P, Bhinder B, Hooper W, Elemento O, Robine N, Rodriguez MG, Gerhardt J, Mouw KW, Chelico L, Faltas BM

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2025.10.21.682588 PMID: 41278855

Variability in HIV-1 transmitted/founder virus susceptibility to combined APOBEC3F and APOBEC3G host restriction.

Gaba A, Yousefi M, Bhattacharjee S, Chelico L

Journal of virology2025Senior author

DOI: 10.1128/jvi.01606-24 PMID: 39714157

In vitro deamination assay to measure the activity and processivity of AID/APOBEC enzymes.

Chelico L, Feng Y

Methods in enzymology2025First author

DOI: 10.1016/bs.mie.2024.11.038 PMID: 40250961

Purification of enzymatically active APOBEC proteins from an insect cell expression system.

Chelico L, Adolph MB

Methods in enzymology2025First author

DOI: 10.1016/bs.mie.2024.11.035 PMID: 40250960

Protein Interaction Map of APOBEC3 Enzyme Family Reveals Deamination-Independent Role in Cellular Function.

Jang GM, Annan Sudarsan AK, Shayeganmehr A, Prando Munhoz E, Lao R, Gaba A, Granadillo Rodríguez M, Love RP, Polacco BJ, Zhou Y, Krogan NJ, Kaake RM, Chelico L

Molecular & cellular proteomics : MCP2024Senior author

DOI: 10.1016/j.mcpro.2024.100755 PMID: 38548018

Protein interaction map of APOBEC3 enzyme family reveals deamination-independent role in cellular function.

Jang GM, Sudarsan AKA, Shayeganmehr A, Munhoz EP, Lao R, Gaba A, Rodríguez MG, Love RP, Polacco BJ, Zhou Y, Krogan NJ, Kaake RM, Chelico L

bioRxiv : the preprint server for biology2024Senior author

DOI: 10.1101/2024.02.06.579137 PMID: 38370690

Similar deamination activities but different phenotypic outcomes induced by APOBEC3 enzymes in breast epithelial cells.

Granadillo Rodríguez M, Wong L, Chelico L

Frontiers in genome editing2023Senior author

DOI: 10.3389/fgeed.2023.1196697 PMID: 37324648

The Cytidine Deaminase APOBEC3G Contributes to Cancer Mutagenesis and Clonal Evolution in Bladder Cancer.

Liu W, Newhall KP, Khani F, Barlow L, Nguyen D, Gu L, Eng K, Bhinder B, Uppal M, Récapet C, Sboner A, Ross SR, Elemento O, Chelico L, Faltas BM

Cancer research2023

DOI: 10.1158/0008-5472.can-22-2912 PMID: 36480186

Role of APOBEC3 single-stranded DNA cytosine deaminases in breast cancer

Nominated PICIHR2025Project Grant

Principal investigators: Chelico, Linda

Keywords: Cell Transformation; Chromosomal Instability; Deaminase; Dna Repair; Dna Replication; Mouse Xenograft Model; Protein-Dna Interactions; Protein-Protein Interactions; Somatic Mutagenesis; Whole Genome Sequencing

$1,029,202

Role of APOBEC3 single-stranded DNA cytosine deaminases in breast cancer

Nominated PICIHR2024Project Grant - PA - Breast Cancer Prevention & Early Detection

Principal investigators: Chelico, Linda

Keywords: Cell Transformation; Chromosomal Instability; Deaminase; Dna Repair; Dna Replication; Humanized Mouse Model; Mouse Xenograft Model; Protein-Dna Interactions; Protein-Protein Interactions; Somatic Mutagenesis

$100,000

Role of APOBEC3 single-stranded DNA cytosine deaminases in breast cancer

Nominated PICIHR2024Project Grant - PA - Breast Cancer Prevention & Early Detection

Principal investigators: Chelico, Linda

$100,000

The on-going conflict between APOBEC3 immune factors and HIV Vif

Nominated PICIHR2024Project Grant - Priority Announcement: Infection and Immunity

Principal investigators: Chelico, Linda

Keywords: Apobec3; Deaminase; Hiv; Mutagenesis; Protein-Protein Interactions; Restriction Factor; Structure-Function Study; Virus Evolution

$100,000

13th Gordon Research Conference on RNA and DNA Editing

Nominated PICIHR2022Planning and Dissemination Grant - Institute Community Support

Principal investigators: Chelico, Linda

Keywords: Base Editing; Cancer; Conference; Dna; Gene Therapy; Inhereted Diseases; Networking; Ribosome; Rna; Training

$10,000

Wuniska! Indigenous Centre on HIV/HCV/STBBI Inequities

Co-investigatorCIHR2019Centres for HIV/AIDS, Hepatitis C and STBBIs Research - Indigenous populations

Principal investigators: King, Alexandra; Gervais, Laverne; Hillstrom, Knighton F; McLeod, Albert; Payne, Michael J; Elias, Brenda D; Jennings, Derek; Johnson-Jennings, Michelle; Kim, John E; Wilson, Alexandria M

Keywords: Addictions Prevention And Care In Indigenous People; Cultural Safety And Responsiveness; Gender-Transformative Research; Health Inequities; Health Systems Transformation; Hiv, Hepatitis C And/Or Other Stbbis; Indigenous Health And Wellness Promotion/Disease Prevention; Innovative Prevention, Testing And Care Approaches; Land- And Culture-Based Healing; Two-Eyed Seeing

$2,841,137

Sanctum 1.5's hope through strength: A novel, women-directed and community-based approach to wholistic care for mother-infant pairs experiencing a substance use disorder and/or HIV

Co-investigatorCIHR2019Project Grant

Principal investigators: Maposa, Sithokozile; Johnson-Jennings, Michelle; King, Alexandra; Roberts, Katelyn

Keywords: Culturally Responsive; Evaluation And Research Model; Harm Reduction And Substance Use Disorder; Hiv And Addictions Prevention And Treatment; Indigenous Women'S Health; Maternal And Neonatal Health; Pregnancy And Parenting; Trauma-Informed Care; Wholistic Health And Wellness; Women-Centred And Directed

$1,231,652

The on-going conflict between APOBEC3 immune factors and HIV-1 Vif

Nominated PICIHR2018Project Grant

Principal investigators: Chelico, Linda

Keywords: Apobec3; Deaminase; Dna-Protein Interactions; Hiv; Mutagenesis; Protein-Protein Interactions; Restriction Factor; Rna-Protein Interactions

$864,450

Role of APOBEC3 deoxycytidine deaminases in somatic mutagenesis

Nominated PICIHR2018Project Grant

Principal investigators: Chelico, Linda

Keywords: Cell Transformation; Deaminase; Dna Modification; Dna Replication; Gene Transcription; Mouse Xenograft Model; Next Generation Sequencing; Protein-Dna Interactions; Protein-Protein Interactions; Somatic Mutagenesis

$822,376

Indigenous Peoples' Health Research Centre

Co-investigatorCIHR2018Operating Grant: Network Environments for Indigenous Health Research- Dev Grants

Principal investigators: Tait, Caroline L; Starblanket, Noel; LaVallie, Carrie; Sasakamoose, JoLee

Keywords: Community Based Research; Ethics; First Nations; Health Equity; Health Services; Indigenous; Metis; Public Health; Remote; Rural

$75,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Linda Chelico

Research

Latest papers

Latest funding

Both Domains of APOBEC3F Recognize AA RNA Motifs to Support HIV-1 Virion Encapsidation and Antiviral Function.

Differential effects on tumor progression by APOBEC3A, APOBEC3B, and APOBEC3H Haplotype I in a breast cancer mouse xenograft model.

APOBEC3A-Induced DNA Damage Drives Polymerase &#x3b8; Dependency and Synthetic Lethality in Cancer.

Variability in HIV-1 transmitted/founder virus susceptibility to combined APOBEC3F and APOBEC3G host restriction.

In vitro deamination assay to measure the activity and processivity of AID/APOBEC enzymes.

Purification of enzymatically active APOBEC proteins from an insect cell expression system.

Protein Interaction Map of APOBEC3 Enzyme Family Reveals Deamination-Independent Role in Cellular Function.

Protein interaction map of APOBEC3 enzyme family reveals deamination-independent role in cellular function.

Similar deamination activities but different phenotypic outcomes induced by APOBEC3 enzymes in breast epithelial cells.

The Cytidine Deaminase APOBEC3G Contributes to Cancer Mutagenesis and Clonal Evolution in Bladder Cancer.

APOBEC3A-Induced DNA Damage Drives Polymerase θ Dependency and Synthetic Lethality in Cancer.