Frederick West, University of Alberta

Research

Antiviral Broad Spectrum Nasal Spray Polymerase Prophylactic Sars-Cov2 Therapeutic

Latest papers

Nano-delivery of a novel inhibitor of ERCC1-XPF for targeted sensitization of colorectal cancer to platinum-based chemotherapeutics.
Drug delivery and translational research · 2025
Discovery of allosteric SHP2 inhibitors through ensemble-based consensus molecular docking, endpoint and absolute binding free energy calculations.
Computers in biology and medicine · 2023
PET Imaging of Fructose Metabolism in a Rodent Model of Neuroinflammation with 6-[18F]fluoro-6-deoxy-D-fructose.
Molecules (Basel, Switzerland) · 2022

All 5 publications

Latest funding

Nano-carriers of novel inhibitors of DNA repair for enhanced therapy in unresectable lung cancer
CIHR · 2024 · Co-investigator
$868,275
Conjugation- and Strain-Driven Formation of Strategic C-C and C-X Bonds
NSERC · 2024 · Principal investigator
$110,000
Clozapine toxicity mechanisms and mitigation strategies
CIHR · 2023 · Co-investigator
$707,625

All 20 grants and awards

5 publications.

01

Nano-delivery of a novel inhibitor of ERCC1-XPF for targeted sensitization of colorectal cancer to platinum-based chemotherapeutics.

Mehinrad P, Abdelfattah A, Sadat SMA, Shafaati T, Elmenoufy AH, Jay D, West F, Weinfeld M, Lavasanifar A

Drug delivery and translational research2025

DOI: 10.1007/s13346-024-01782-9 PMID: 39878858

02

Discovery of allosteric SHP2 inhibitors through ensemble-based consensus molecular docking, endpoint and absolute binding free energy calculations.

Jama M, Ahmed M, Jutla A, Wiethan C, Kumar J, Moon TC, West F, Overduin M, Barakat KH

Computers in biology and medicine2023

DOI: 10.1016/j.compbiomed.2022.106442 PMID: 36566625

03

PET Imaging of Fructose Metabolism in a Rodent Model of Neuroinflammation with 6-[18F]fluoro-6-deoxy-D-fructose.

Boyle AJ, Murrell E, Tong J, Schifani C, Narvaez A, Wuest M, West F, Wuest F, Vasdev N

Molecules (Basel, Switzerland)2022

DOI: 10.3390/molecules27238529 PMID: 36500626

04

Molecular Imaging of GLUT1 and GLUT5 in Breast Cancer: A Multitracer Positron Emission Tomography Imaging Study in Mice.

Wuest M, Hamann I, Bouvet V, Glubrecht D, Marshall A, Trayner B, Soueidan OM, Krys D, Wagner M, Cheeseman C, West F, Wuest F

Molecular pharmacology2018

DOI: 10.1124/mol.117.110007 PMID: 29142019

05

Structures reveal details of small molecule binding to cardiac troponin.

Cai F, Li MX, Pineda-Sanabria SE, Gelozia S, Lindert S, West F, Sykes BD, Hwang PM

Journal of molecular and cellular cardiology2016

DOI: 10.1016/j.yjmcc.2016.10.016 PMID: 27825981

Nano-carriers of novel inhibitors of DNA repair for enhanced therapy in unresectable lung cancer

Co-investigatorCIHR2024Project Grant

Principal investigators: Lavasanifar, Afsaneh

Keywords: Cancer; Chemotherapy; Dna Damage; Dna Repair; Drug Delivery; Imaging; Nanotechnology; Radiotherapy

$868,275

Conjugation- and Strain-Driven Formation of Strategic C-C and C-X Bonds

Principal investigatorNSERC2024Discovery Grants Program - Individual

Principal investigators: West, Frederick

Keywords: allenes; ring strain; metallocarbenes; cycloadditions; transition metal catalysis

$110,000

Clozapine toxicity mechanisms and mitigation strategies

Co-investigatorCIHR2023Project Grant

Principal investigators: Siraki, Arno

Keywords: Adverse Drug Reactions; Clozapine; Drug Toxicity; Edaravone; Myeloperoxidase; Neutrophils

$707,625

Advancing the therapeutic opportunity for TLR4 in reducing cisplatin-induced ototoxicity

Co-investigatorCIHR2021Project Grant

Principal investigators: Bhavsar, Amit P

Keywords: Chemotherapy-Related Toxicity; Childhood Cancer Treatment; Hearing Loss; Innate Immune Receptor; Innovative Pharmacological Agents; Otoprotectant Development; Small Molecule Screening

$956,250

Scalable Synthesis of Antiviral Compounds (COVID-19)_x000d_

Principal investigatorNSERC2020Alliance Grants

Principal investigators: West, Frederick

$50,000

Liquid Chromatography System with Mass-Based Analysis and Purification to Support Departmental Reaction Optimization and Medicinal Chemistry Programs

Co-investigatorNSERC2020Research Tools and Instruments

Principal investigators: Hall, Dennis

$150,000

Broad-spectrum Antiviral Nasal Spray to Prevent and treat Infection by SARS-CoV2 and Seasonal Respiratory Viruses in High Risk Patients and Health Care Providers

Principal investigatorCIHR2020Operating Grant: COVID-19 Rapid Research Funding Opportunity - Therapeutics

Principal investigators: Marchant, David J; West, Frederick G

Keywords: Antiviral; Broad Spectrum; Nasal Spray; Polymerase; Prophylactic; Sars-Cov2; Therapeutic

Novel Bond-Forming Processes Based on Energetic Intermediates

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: West, Frederick

$564,000

Development of New Stereoselective Routes to Fluorinated Butyrolactones

Principal investigatorNSERC2015Engage Grants Program

Principal investigators: West, Frederick

$25,000

High-Throughput Ultra High Pressure Liquid Chromatography/Mass Spectrometry Instrument

Co-investigatorNSERC2014Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Lundgren, Rylan

$150,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Oncology
Medical Microbiology and Immunology
Other

Co-authors at University of Alberta, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Neil Vasdev

Faculty

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2024

Subject: Prospective PhD student: Antiviral Dear Professor West, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Nano-delivery of a novel inhibitor of ERCC1-XPF for targeted sensitization of colorectal cancer to platinum-based chemotherapeutics." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Conjugation- and Strain-Driven Formation of Strategic C-C and C-X Bonds" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Frederick West

Research

Latest papers

Latest funding

Nano-delivery of a novel inhibitor of ERCC1-XPF for targeted sensitization of colorectal cancer to platinum-based chemotherapeutics.

Discovery of allosteric SHP2 inhibitors through ensemble-based consensus molecular docking, endpoint and absolute binding free energy calculations.

PET Imaging of Fructose Metabolism in a Rodent Model of Neuroinflammation with 6-[18F]fluoro-6-deoxy-D-fructose.

Molecular Imaging of GLUT1 and GLUT5 in Breast Cancer: A Multitracer Positron Emission Tomography Imaging Study in Mice.

Structures reveal details of small molecule binding to cardiac troponin.

Nano-carriers of novel inhibitors of DNA repair for enhanced therapy in unresectable lung cancer

Conjugation- and Strain-Driven Formation of Strategic C-C and C-X Bonds

Clozapine toxicity mechanisms and mitigation strategies

Advancing the therapeutic opportunity for TLR4 in reducing cisplatin-induced ototoxicity

Scalable Synthesis of Antiviral Compounds (COVID-19)_x000d_

Liquid Chromatography System with Mass-Based Analysis and Purification to Support Departmental Reaction Optimization and Medicinal Chemistry Programs

Broad-spectrum Antiviral Nasal Spray to Prevent and treat Infection by SARS-CoV2 and Seasonal Respiratory Viruses in High Risk Patients and Health Care Providers

Novel Bond-Forming Processes Based on Energetic Intermediates

Development of New Stereoselective Routes to Fluorinated Butyrolactones

High-Throughput Ultra High Pressure Liquid Chromatography/Mass Spectrometry Instrument

Frequent collaborators

Frank Wuest

Christin Schifani

Afsaneh Lavasanifar

Michael Weinfeld

Neil Vasdev