Matthew Croxen, University of Alberta

Research

Bioinformatics Covid-19 Genomics Infectious Diseases Surveillance

Latest papers

The assembly of a hybrid type IV secretion system by a Crohn's disease-associated Escherichia coli strain.
Nature communications · 2025
Group A streptococcal infections in Alberta, Canada 2018-2023.
Epidemiology and infection · 2024
The association between phylogenetic lineage and the subclinical phenotype of pulmonary tuberculosis: A retrospective 2-cohort study.
The Journal of infection · 2024

All 8 publications

Latest funding

Population genomic, bioinformatic, and molecular parasitological assessment of diversity and function of the membrane-trafficking machinery in Giardia intestinalis, a common Canadian enteric pathogen.
CIHR · 2020 · Supervisor
$105,000
Rapid RNA sequencing of coronavirus for public health surveillance and transmission
CIHR · 2020 · Nominated PI
$630,432

All 2 grants and awards

8 publications.

01

The assembly of a hybrid type IV secretion system by a Crohn's disease-associated Escherichia coli strain.

Wong J, Refaat A, Villacampa-Teixeira P, Patkowski JB, Lapa N, Ortiz J, Dzierlega K, Roberts B, Tollenaar S, Croxen M, Thiesen A, Kao D, Willing B, Clemente-Casares X, Costa TRD, Elhenawy W

Nature communications2025

DOI: 10.1038/s41467-025-63859-4 PMID: 41038829

02

Group A streptococcal infections in Alberta, Canada 2018-2023.

Tyrrell GJ, Croxen M, McCullough E, Li V, Golden AR, Martin I

Epidemiology and infection2024

DOI: 10.1017/s0950268824001857 PMID: 39711024

03

The association between phylogenetic lineage and the subclinical phenotype of pulmonary tuberculosis: A retrospective 2-cohort study.

Long R, Croxen M, Lee R, Doroshenko A, Lau A, Asadi L, Heffernan C, Paulsen C, Egedahl ML, Lloyd C, Li V, Tyrrell G

The Journal of infection2024

DOI: 10.1016/j.jinf.2023.12.006 PMID: 38104727

04

Analysis of invasive group A streptococcal puerperal sepsis in Calgary, Alberta: clinical consequences and policy implications

Qaddoura A, McQuiston M, Tyrrell G, Croxen M, Li V, Demarco R, Pinfield S, Ramazanova R, Hope K, Cairns E-R

Infection Control and Hospital Epidemiology2024

DOI: 10.1017/ice.2024.154

05

How much do smear-negative patients really contribute to tuberculosis transmissions? Re-examining an old question with new tools.

Asadi L, Croxen M, Heffernan C, Dhillon M, Paulsen C, Egedahl ML, Tyrrell G, Doroshenko A, Long R

EClinicalMedicine2022

DOI: 10.1016/j.eclinm.2021.101250 PMID: 35036885

06

SARS-COV-2 recombinant Receptor-Binding-Domain (RBD) induces neutralizing antibodies against variant strains of SARS-CoV-2 and SARS-CoV-1.

Law JLM, Logan M, Joyce MA, Landi A, Hockman D, Crawford K, Johnson J, LaChance G, Saffran HA, Shields J, Hobart E, Brassard R, Arutyunova E, Pabbaraju K, Croxen M, Tipples G, Lemieux MJ, Tyrrell DL, Houghton M

Vaccine2021

DOI: 10.1016/j.vaccine.2021.08.081 PMID: 34481699

07

Retrospective testing of respiratory specimens for COVID-19 to assess for earlier SARS-CoV-2 infections in Alberta, Canada.

Kanji JN, Diggle M, Bulman DE, Hume S, Taylor S, Kelln R, Haase S, Tomaszewski R, Walker C, Pabbaraju K, Li V, Croxen M, Zelyas N, Hinshaw D, Tipples G

Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada2021

DOI: 10.3138/jammi-2020-0035 PMID: 36340216

08

Antibodies to the conserved region of the M protein and a streptococcal superantigen cooperatively resolve toxic shock-like syndrome in HLA-humanized mice.

Pandey M, Calcutt A, Ozberk V, Chen Z, Croxen M, Powell J, Langshaw E, Mills JL, Jen FE, McCluskey J, Robson J, Tyrrell GJ, Good MF

Science advances2019

DOI: 10.1126/sciadv.aax3013 PMID: 31517054

Population genomic, bioinformatic, and molecular parasitological assessment of diversity and function of the membrane-trafficking machinery in Giardia intestinalis, a common Canadian enteric pathogen.

SupervisorCIHR2020Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Pipaliya, Shweta

Keywords: Bioinformatics; Evolution; Gastrointestinal Infection; Genome Assembly; Infectious Diseases; Membrane Trafficking; Microbial Parasites; Molecular Biology; Parasitology; Population Genomics

$105,000

Rapid RNA sequencing of coronavirus for public health surveillance and transmission

Nominated PICIHR2020Operating Grant: COVID-19 - Diagnostics

Principal investigators: Croxen, Matthew A; Gordon, Paul; Van Domselaar, Gary H

Keywords: Bioinformatics; Covid-19; Genomics; Infectious Diseases; Surveillance

$630,432

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Community Health Sciences
Laboratory Medicine and Pathology
Laboratory Medicine & Pathobiology
Medical Microbiology
Medical Microbiology and Immunology

Co-authors at University of Alberta, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Gregory Tyrrell

Medicine

2 shared papers, latest 2024

Courtney Heffernan

Medicine

2 shared papers, latest 2024

Richard Long

Medicine

2 shared papers, latest 2024

Deena Hinshaw

Laboratory Medicine & Pathobiology

1 shared papers, latest 2021

Deena Hinshaw

Medicine

1 shared papers, latest 2021

Jia Hu

Community Health Sciences

1 shared papers, latest 2024

Wael Elhenawy

Medical Microbiology and Immunology

1 shared papers, latest 2025

Karen Hope

Community Health Sciences

1 shared papers, latest 2024

Amro Qaddoura

Medicine

1 shared papers, latest 2024

John Conly

Medicine

1 shared papers, latest 2024

Michael Houghton

Medicine

1 shared papers, latest 2021

Oscar Larios

Medical Microbiology

1 shared papers, latest 2024

Dina Kao

Medicine

1 shared papers, latest 2025

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2020

Subject: Prospective PhD student: Bioinformatics Dear Professor Croxen, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The assembly of a hybrid type IV secretion system by a Crohn's disease-associated Escherichia coli strain." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Rapid RNA sequencing of coronavirus for public health surveillance and transmission" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]