Penelope Smyth, University of Alberta

Research

Depression Multiple Sclerosis Systematic Review

Latest papers

High-resolution fluid-suppressed diffusion tractography of the fornix across the healthy lifespan and deviations in multiple sclerosis.
Imaging neuroscience (Cambridge, Mass.) · 2026
Patient reported outcomes in NMOSD reflect a high disease burden and do not correlate with the EDSS.
Multiple sclerosis and related disorders · 2026
Importance of R2 accuracy in susceptibility source separation.
Magnetic resonance in medicine · 2026

All 56 publications

Latest funding

New Susceptibility MRI Methods for Progressive Multiple Sclerosis
CIHR · 2025 · Co-investigator
$837,675
Examining intersections of biographies & biologies: diversity & outcomes of people with multiple sclerosis in Canada (iBio2Div-MS)
CIHR · 2024 · Co-investigator
$19,955
Examining intersections of biographies & biologies: diversity & outcomes of people with multiple sclerosis in Canada (iBio2Div-MS)
CIHR · 2024 · Co-investigator
$1,999,180

All 5 grants and awards

56 publications.

01

High-resolution fluid-suppressed diffusion tractography of the fornix across the healthy lifespan and deviations in multiple sclerosis.

Weber C, Smyth P, Blevins G, Wilbur C, Emery D, Beaulieu C

Imaging neuroscience (Cambridge, Mass.)2026

DOI: 10.1162/imag.a.1186 PMID: 41924030

02

Patient reported outcomes in NMOSD reflect a high disease burden and do not correlate with the EDSS.

Saeedzadeh E, Vyas MV, Sharma S, Vas N, Carruthers R, Chertcoff A, Casserly C, Freedman MS, Lee L, Marrie RA, McCombe JA, Morrow SA, Parks NE, Smyth P, Rotstein DL

Multiple sclerosis and related disorders2026

DOI: 10.1016/j.msard.2026.107223 PMID: 42116255

03

Importance of R2 accuracy in susceptibility source separation.

Oliveira Assunção TB, Naji N, Snyder J, Seres P, Blevins G, Smyth P, Wilman AH

Magnetic resonance in medicine2026

DOI: 10.1002/mrm.70034 PMID: 40818093

04

Patient experiences with systematically-administered patient-reported outcome measures in multiple sclerosis.

Desbiens V, Wong G, Liu S, Chu NY, Watson KE, Smyth P, Tsuyuki RT

Multiple sclerosis and related disorders2026

DOI: 10.1016/j.msard.2026.107201 PMID: 42025274

05

First-Line Use of Higher-Efficacy Disease-Modifying Therapies in Multiple Sclerosis: Canadian Consensus Recommendations.

Freedman MS, Clift F, Devonshire V, Émond F, Larochelle C, Levin MC, MacLean H, Morrow SA, Prat A, Selchen D, Smyth P, Vorobeychik G

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques2025

DOI: 10.1017/cjn.2025.10342 PMID: 40485478

06

Whole Brain 3D T1 Mapping in Multiple Sclerosis Using Standard Clinical Images Compared to MP2RAGE and MR Fingerprinting.

Snyder J, Blevins G, Smyth P, Wilman AH

NMR in biomedicine2025

DOI: 10.1002/nbm.70037 PMID: 40235062

07

Comparison of vision-related quality of life in NMOSD and MOGAD.

Gassan AA, Konig A, Nisenbaum R, Freedman MS, Lee L, Marrie RA, McCombe JA, Micieli J, Morrow SA, Parks NE, Smyth P, Rotstein DL

Multiple sclerosis and related disorders2025

DOI: 10.1016/j.msard.2025.106392 PMID: 40157039

08

Indigenous Peoples Living with Multiple Sclerosis in Canada.

Nathoo N, Clark WI, Robinson R, Jarvis S, Balcom EF, Kung JY, Smyth P

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques2025Senior author

DOI: 10.1017/cjn.2025.42 PMID: 40034045

09

Quality and Scope of Published International Guidelines for Multiple Sclerosis Care: AGREE II Appraisal.

Donkers SJ, Berscheid M, Bayley M, Bruno TR, Pilutti LA, Simpson R, Smyth P, Walker LAS, Knox KB, AGREE Working Group of the Canadian MS Rehabilitation Knowledge Mobilization Network

NeuroRehabilitation2025

DOI: 10.1177/10538135251387611 PMID: 41230620

10

Building Bridges: Establishing a Multiple Sclerosis Rehabilitation Research and Clinical Knowledge Mobilization Strategy.

Donkers SJ, Bayley M, Bruno TR, Marrie RA, Simpson R, Smyth P, Knox KB

NeuroRehabilitation2025

DOI: 10.1177/10538135251365102 PMID: 40879432

New Susceptibility MRI Methods for Progressive Multiple Sclerosis

Co-investigatorCIHR2025Project Grant

Principal investigators: Wilman, Alan H

Keywords: Brain; Demyelination; Mri; Mri Development; Multiple Sclerosis; Neurodegeneration; Susceptibility Mapping

$837,675

Examining intersections of biographies & biologies: diversity & outcomes of people with multiple sclerosis in Canada (iBio2Div-MS)

Co-investigatorCIHR2024Team Gr.: Emb. Diversity to Achieve Precision/Health Eq-Infection & Immunity-LOI

Principal investigators: Marrie, Ruth Ann; Finlayson, Marcia L

Keywords: Multiple Sclerosis

$19,955

Examining intersections of biographies & biologies: diversity & outcomes of people with multiple sclerosis in Canada (iBio2Div-MS)

Co-investigatorCIHR2024Team Gr.: Embracing Diversity to Achieve Precision & Health Equity-General Omics

Principal investigators: Marrie, Ruth Ann; Fakolade, Afolasade; Finlayson, Marcia L; Kowalec, Kaarina A

Keywords: Multiple Sclerosis

$1,999,180

Relaxation Mapping for the Clinic: Application to Multiple Sclerosis

Co-investigatorCIHR2021Project Grant

Principal investigators: Wilman, Alan H

Keywords: Mri; Multiple Sclerosis; Relaxation Mapping

$753,525

Depression and Multiple Sclerosis: A Systematic Review

Principal investigatorCIHR2013Knowledge Synthesis Grant

Principal investigators: Carroll, Linda J; Finlayson, Marcia L; Marrie, Ruth Ann; Smyth, Penelope; Upshall, Philip C; Wheeler, Garry D

Keywords: Depression; Multiple Sclerosis; Systematic Review

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Shannon Kolind and Anthony Traboulsee: 30 shared papers
Alexandre Prat and Nathalie Arbour: 28 shared papers
Alexandre Prat and Catherine Larochelle: 27 shared papers
Mahesh Kate and Brian Buck: 24 shared papers
Jiwon Oh and Anthony Traboulsee: 23 shared papers
Mark Bayley and Robert Simpson: 19 shared papers
Alexandre Prat and Jiwon Oh: 17 shared papers
Nathalie Arbour and Catherine Larochelle: 17 shared papers
Jiwon Oh and Shannon Kolind: 15 shared papers
Kenneth Butcher and Mahesh Kate: 13 shared papers
Kenneth Butcher and Brian Buck: 13 shared papers
Helen Tremlett and Anthony Traboulsee: 9 shared papers
Tyler Williamson and Lawrence Richer: 9 shared papers
Alexandre Prat and Shannon Kolind: 8 shared papers
Penelope Smyth and Jiwon Oh: 8 shared papers
Christian Beaulieu and Mahesh Kate: 6 shared papers
Christian Beaulieu and Brian Buck: 6 shared papers
Jiwon Oh and Fabrizio Giuliani: 6 shared papers
Christian Beaulieu and Penelope Smyth: 5 shared papers
Penelope Smyth and Anthony Traboulsee: 5 shared papers
Penelope Smyth and Mahesh Kate: 5 shared papers
Anthony Traboulsee and Fabrizio Giuliani: 5 shared papers
Kenneth Butcher and Christian Beaulieu: 4 shared papers
Helen Tremlett and Marcia Finlayson: 4 shared papers
Marshall Godwin and Michelle Ploughman: 4 shared papers
Alexandre Prat and Penelope Smyth: 4 shared papers
Marcia Finlayson and Michelle Ploughman: 4 shared papers
Penelope Smyth and Fabrizio Giuliani: 4 shared papers
Larry Lynd and Jiwon Oh: 4 shared papers
Larry Lynd and Anthony Traboulsee: 4 shared papers
Nathalie Arbour and Jiwon Oh: 4 shared papers
Mark Bayley and Jiwon Oh: 4 shared papers
Jiwon Oh and Robert Simpson: 4 shared papers
Helen Tremlett and Penelope Smyth: 3 shared papers
Marshall Godwin and Tyler Williamson: 3 shared papers
Marcia Finlayson and Jiwon Oh: 3 shared papers
Penelope Smyth and Nathalie Arbour: 3 shared papers
Penelope Smyth and Tyler Williamson: 3 shared papers
Penelope Smyth and Shannon Kolind: 3 shared papers
Penelope Smyth and Lawrence Richer: 3 shared papers
Michelle Ploughman and Nancy Mayo: 3 shared papers
Lawrence Richer and Mahesh Kate: 3 shared papers
Draga Jichici and Penelope Smyth: 2 shared papers
Draga Jichici and Jiwon Oh: 2 shared papers
Kenneth Butcher and Penelope Smyth: 2 shared papers
Marshall Godwin and Penelope Smyth: 2 shared papers
Marshall Godwin and Nancy Mayo: 2 shared papers
Alexandre Prat and Larry Lynd: 2 shared papers
Marcia Finlayson and Penelope Smyth: 2 shared papers
Penelope Smyth and Larry Lynd: 2 shared papers
Penelope Smyth and Michelle Ploughman: 2 shared papers
Penelope Smyth and Nancy Mayo: 2 shared papers
Penelope Smyth and Mark Bayley: 2 shared papers
Penelope Smyth and Robert Simpson: 2 shared papers
Penelope Smyth and Brian Buck: 2 shared papers
Catherine Larochelle and Jiwon Oh: 2 shared papers
Penelope Smyth and Cheryl Barnabe: 1 shared paper
Penelope Smyth and Catherine Larochelle: 1 shared paper
Penelope Smyth and Aleem Bharwani: 1 shared paper
Cheryl Barnabe and Tyler Williamson: 1 shared paper
Cheryl Barnabe and Aleem Bharwani: 1 shared paper

Medicine
Medicine/Neurology
Biomedical Engineering
Neurosciences
Public Health Sciences
Immunology
Neurologie
Other

Co-authors at University of Alberta, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Anthony Traboulsee

Medicine/Neurology

5 shared papers, latest 2025

Christian Beaulieu

Biomedical Engineering

5 shared papers, latest 2026

Fabrizio Giuliani

Medicine/Neurology

4 shared papers, latest 2025

Alexandre Prat

Neurosciences

4 shared papers, latest 2025

Shannon Kolind

Medicine/Neurology

3 shared papers, latest 2025

Tyler Williamson

Community Health Sciences

3 shared papers, latest 2024

Helen Tremlett

Medicine/Neurology

3 shared papers, latest 2025

Michelle Ploughman

Biomedical Sciences

2 shared papers, latest 2015

Mark Bayley

Physical Therapy

2 shared papers, latest 2025

Nancy Mayo

Clinical Epidemiology

2 shared papers, latest 2015

Marshall Godwin

Family Medicine

2 shared papers, latest 2015

Kenneth Butcher

Biomedical Engineering

2 shared papers, latest 2018

Kannin Osei-Tutu

Family Medicine

1 shared papers, latest 2024

Heather Maclean

Department of Medicine

1 shared papers, latest 2025

Juthaporn Cowan

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2024

Doreen Rabi

Medicine/Endocrinology/Metabolism

1 shared papers, latest 2024

Rosane Nisenbaum

Biostatistics Division

1 shared papers, latest 2025

Mojgan Hodaie

Department of Surgery

1 shared papers, latest 2025

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mention

Subject: Prospective PhD student: Depression Dear Professor Smyth, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "High-resolution fluid-suppressed diffusion tractography of the fornix across the healthy lifespan and deviations in multiple sclerosis." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Penelope Smyth

Research

Latest papers

Latest funding

High-resolution fluid-suppressed diffusion tractography of the fornix across the healthy lifespan and deviations in multiple sclerosis.

Patient reported outcomes in NMOSD reflect a high disease burden and do not correlate with the EDSS.

Importance of R2 accuracy in susceptibility source separation.

Patient experiences with systematically-administered patient-reported outcome measures in multiple sclerosis.

First-Line Use of Higher-Efficacy Disease-Modifying Therapies in Multiple Sclerosis: Canadian Consensus Recommendations.

Whole Brain 3D T1 Mapping in Multiple Sclerosis Using Standard Clinical Images Compared to MP2RAGE and MR Fingerprinting.

Comparison of vision-related quality of life in NMOSD and MOGAD.

Indigenous Peoples Living with Multiple Sclerosis in Canada.

Quality and Scope of Published International Guidelines for Multiple Sclerosis Care: AGREE II Appraisal.

Building Bridges: Establishing a Multiple Sclerosis Rehabilitation Research and Clinical Knowledge Mobilization Strategy.

New Susceptibility MRI Methods for Progressive Multiple Sclerosis

Examining intersections of biographies & biologies: diversity & outcomes of people with multiple sclerosis in Canada (iBio2Div-MS)

Examining intersections of biographies & biologies: diversity & outcomes of people with multiple sclerosis in Canada (iBio2Div-MS)

Relaxation Mapping for the Clinic: Application to Multiple Sclerosis

Depression and Multiple Sclerosis: A Systematic Review

Frequent collaborators

Jiwon Oh

Anthony Traboulsee

Mahesh Kate

Christian Beaulieu

Fabrizio Giuliani

Alexandre Prat

Shannon Kolind

Nathalie Arbour

Lawrence Richer

Tyler Williamson

Helen Tremlett

Michelle Ploughman

Brian Buck

Mark Bayley

Larry Lynd

Robert Simpson

Nancy Mayo

Marshall Godwin

Draga Jichici

Marcia Finlayson

Kenneth Butcher

Kannin Osei-Tutu

Heather Maclean

Juthaporn Cowan

Doreen Rabi

Rosane Nisenbaum

Cheryl Barnabe

Mojgan Hodaie