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Research
Latest papers
Hepatitis B Virus Genotype Influence on Virological and Enzymatic Measures over Time-A Retrospective Longitudinal Cohort Study.
Journal of clinical medicine · 2023
Ribavirin Does Not Enhance Hepatitis B Virus Nucleotide Antiviral Activity: A Pilot Study.
Clinical and investigative medicine. Medecine clinique et experimentale · 2022
Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature.
Case reports in medicine · 2019
Latest funding
- $3,749,969
Pathways to Functional Cure in Chronic Hepatitis B
CIHR · 2024 · Nominated PI
- $20,000
Progress Toward The Elimination of Hepatitis B in Canada
CIHR · 2023 · Nominated PI
- $105,000
Development of a therapeutic single domain antibody to target the hepatitis B virus covalently closed circular DNA genome
CIHR · 2022 · Supervisor
6 publications.
Hepatitis B Virus Genotype Influence on Virological and Enzymatic Measures over Time-A Retrospective Longitudinal Cohort Study.
Keeshan A, da Silva CF, Vachon A, Giles E, Osiowy C, Coffin C, Cooper CL
Ribavirin Does Not Enhance Hepatitis B Virus Nucleotide Antiviral Activity: A Pilot Study.
Keeshan A, Coffin C, Vachon A, Patel N, Fung S, Mortimer L, Crawley A, Ma M, Osiowy C, Cooper C
Spontaneous Regression of Hepatocellular Carcinoma and Review of Reports in the Published English Literature.
Chohan MBY, Taylor N, Coffin C, Burak KW, Bathe OF
Review of Laboratory Tests used in Monitoring Hepatitis B Response to Pegylated Interferon and Nucleos(t)ide Analog Therapy.
Osiowy C, Coffin C, Andonov A
A population-based study of pyogenic liver abscesses in the United States: incidence, mortality, and temporal trends.
Meddings L, Myers RP, Hubbard J, Shaheen AA, Laupland KB, Dixon E, Coffin C, Kaplan GG
Improving rates of pneumococcal vaccination on discharge from a tertiary center medical teaching unit: a prospective intervention.
Thomas CM, Loewen A, Coffin C, Campbell NR
Pathways to Functional Cure in Chronic Hepatitis B
Principal investigators: Coffin, Carla S; Ko, Hin Hin; Cooper, Curtis L; Crawley, Angela M; Gehring, Adam J; Jenne, Craig N; Meier-Stephenson, Vanessa
Keywords: Artificial Intelligence (Ai); Flow Cytometry; Functional Cure (Fc); Hepatitis B Virus (Hbv); Human Immunology; Humanized Mouse Liver Model; Liver Disease; Novel Biomarkers; Single Cell Rna Sequencing (Scrnaseq); Woodchuck Hepatitis Virus (Whv) Model
Progress Toward The Elimination of Hepatitis B in Canada
Principal investigators: Coffin, Carla S
Keywords: Antiviral Therapy; Global Health; Hepatitis B; Liver Cancer; Liver Disease; Pregnancy; Public Health; Vaccination; Viral Hepatitis Elimination; World Health Organization
Development of a therapeutic single domain antibody to target the hepatitis B virus covalently closed circular DNA genome
Principal investigators: D'souza, Simmone
Keywords: Antiviral Drug Development; Hepatitis B Virus; Virology
Investigation of Hepatitis B Virus Immunopathogenesis using Intravital Microscopy in the Woodchuck Hepatitis Virus (WHV) Model of Hepatitis B
Principal investigators: Coffin, Carla S; Jenne, Craig N; Michalak, Thomas I
Keywords: Acute And Chronic Hepatitis; Cytokines And Immune Cells; Hepatitis B Virus; Immunohistochemistry And Histology; Immunomodulatory Therapy; Intravital Microscopy; Liver Cancer And Liver Disease; Nucleos(T)Ide Analog Therapy; Peripheral Blood Mononuclear Cells; Woodchuck Hepatitis Virus
Development of a Canadian Hepatitis B Virtual Centre of Excellence
Principal investigators: Coffin, Carla S
Keywords: Antiviral Treatment; Canadian Hbv Network; Centre Of Excellence; Chronic Hepatitis B Infection; Cirrhosis; Health Services; Hepatitis B Virus; Hepatocellular Carcinoma; Liver Disease; Survey
Investigation of Hepatitis B Virus Immunopathogenesis using Intravital Microscopy in the Woodchuck Hepatitis Virus (WHV) Model of Hepatitis B
Principal investigators: Coffin, Carla S; Jenne, Craig N; Michalak, Thomas I
Keywords: Acute And Chronic Hepatitis Infection; Cytokines; Hepatitis B Virus; Immunohistochemistry And Histology; Immunomodulatory Therapy; Intravital Microscopy; Liver Cancer And Liver Disease; Nucleos(T)Ide Analog Therapy; Peripheral Blood Mononuclear Cells; Woodchuck Hepatitis Virus
Evaluating Hepatitis B Virus Covalently Closed Circular DNA Dynamics Within a Hepatitis Delta Virus Co-infection Model
Principal investigators: D'souza, Simmone
Keywords: Circular Dna; Co-Infection Model; Covalently Closed; Hepatitis B Virus
Elucidating the mechanisms of hepatitis B virus specific T cell exhaustion in immune-mediated chronic hepatitis B mouse model
Principal investigators: Patel, Nishi H
Keywords: Hepatitis B; Mechanisms; Mouse Model; T Cell Exhaustion
Pathogenesis of Hepatitis B Virus Infection in Non-Alcoholic Fatty Liver Disease
Principal investigators: Coffin, Carla S
Keywords: Cirrhosis; Diabetes; Hbv Vaccine Responses (Engerixb); Hepatitis B Specific Immune Responses; Hepatitis B Virus (Hbv); Immune Cells; Intravital Imaging; Murine Hbv Model; Non Alcoholic Fatty Liver Disease; Obesity; Primary Liver Cancer (Hepatocellular Carcinoma); Transgenic Hbv Mice
Hepatitis B Virus Infection (HBV) in Human Immunodeficiency Type -1 (HIV-1) Positive Patients
Principal investigators: Coffin, Carla S
Keywords: Antiviral Drug Resistance; Antiviral Immune Response; Chronic And Occult Hepatitis B Virus; Dna Sequencing; Hepatitis Coinfection; Hiv; Liver Disease; Luminex Assays; Lymphoid Cell Culture; Mitogen Stimulation; Nested Pcr/Nucleic Acid Hybridization; Quantitative Pcr; Viral Lymphotropism; Virus Evolution And Genetic Diversity
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Medicine
- Biochemistry, Microbiology & Immunology
- Department of Medicine
Co-authors at University of Calgary, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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