Jane Shearer, University of Calgary

Research

Metabolism Nutrition Metabolomics Animal Model Clinical Neurodevelopment Pediatric Health

Latest papers

Exploring the Placental Lipidome in Physically Active vs. Inactive Pregnancies.
Journal of applied physiology (Bethesda, Md. : 1985) · 2026
Early-Life Dietary Protein Source Reshapes Gut Microbiota but Fails to Curtail Diet-Induced Metabolic Syndrome in Young Rats.
Obesity (Silver Spring, Md.) · 2026 · senior author
SeizureBiomeDB: a unified database of gut microbiome alterations in pediatric and adult epilepsy.
Bioinformatics advances · 2026

All 113 publications

Latest funding

Sex and estrogen-dependent cross-talk between macrophages and adipocyte progenitors during adipose remodelling in obesity.
CIHR · 2024 · Co-investigator
$707,625
Development of a Novel Iron-Based Supplement for Athletes
NSERC · 2023 · Principal investigator
$166,520
Nutritional Manipulation of the Gut-Brain-Axis in Epilepsy
CIHR · 2022 · Nominated PI
$699,976

All 13 grants and awards

113 publications.

01

Exploring the Placental Lipidome in Physically Active vs. Inactive Pregnancies.

MacDonald ML, Yadegari A, Chittaro JT, Dantas A, Wasslen K, Rosales CA, Shearer J, Redman LM, Smith J, Adamo KB

Journal of applied physiology (Bethesda, Md. : 1985)2026

DOI: 10.1152/japplphysiol.00357.2026 PMID: 42735213

02

Early-Life Dietary Protein Source Reshapes Gut Microbiota but Fails to Curtail Diet-Induced Metabolic Syndrome in Young Rats.

Mu C, Hartslief M, Chong J, Shah S, Thompson J, Reimer RA, Wright DC, Shearer J

Obesity (Silver Spring, Md.)2026Senior author

DOI: 10.1002/oby.70266 PMID: 42572931

03

SeizureBiomeDB: a unified database of gut microbiome alterations in pediatric and adult epilepsy.

Walji Z, Dave P, Ali M, Negmeldin O, Toor AK, Shearer J, Mu C

Bioinformatics advances2026

DOI: 10.1093/bioadv/vbag198 PMID: 42639440

04

Mitochondrial Dysfunction in Autism and Attention-Deficit/Hyperactivity Disorder: Evidence from Genetic, Biochemical, and Neuroimaging Approaches.

Ram TR, Mu C, MacEachern SJ, Shearer J

Antioxidants (Basel, Switzerland)2026Senior author

DOI: 10.3390/antiox15060764 PMID: 42352070

05

Role of Acid-Sensing Ion Channels 1a in the Regulation of Obesity and the Gut Microbiota.

Shearer J, Scantlebury MH, Erome-Utunedi O, Choudhary A, Thompson JA, Ohland C, McCoy KD, Mu C

Obesity (Silver Spring, Md.)2026First author

DOI: 10.1002/oby.70059 PMID: 41140006

06

Cross talk between obesogenic diet and estrogen drives distinct microbiota profiles in ovariectomized mice.

Scheidl TB, Wager JL, Shearer J, Thompson JA, Mu C

Physiological genomics2025

DOI: 10.1152/physiolgenomics.00184.2025 PMID: 41237015

07

Altered tryptophan metabolism and gut immune crosstalk in hypertensive middle-aged women.

Shah S, Mu C, Shen-Tu G, Schlicht K, Forkert ND, Laudes M, Köfeler HC, Shearer J

American journal of physiology. Heart and circulatory physiology2025Senior author

DOI: 10.1152/ajpheart.00395.2025 PMID: 41087031

08

Hippocampal proteomic signatures of the ketogenic diet in a model of infantile epileptic spasms syndrome.

Campbell JC, Mu C, Ram TR, Young D, Dufour A, Scantlebury MH, Shearer J

Biochimica et biophysica acta. Molecular basis of disease2025Senior author

DOI: 10.1016/j.bbadis.2025.168011 PMID: 40774521

09

Protocol for measuring mitochondrial respiratory capacity from buccal cell swabs.

Ram TR, Mu C, Campbell JC, MacEachern SJ, Shearer J

STAR protocols2025Senior author

DOI: 10.1016/j.xpro.2025.104004 PMID: 40753577

10

Influence of dietary components on the gut microbiota of middle-aged adults: the gut-Mediterranean connection.

Shah S, Mu C, Shen-Tu G, Rohmann N, Schlicht K, Laudes M, Shearer J

BMC microbiology2025Senior author

DOI: 10.1186/s12866-025-04170-6 PMID: 40914795

Sex and estrogen-dependent cross-talk between macrophages and adipocyte progenitors during adipose remodelling in obesity.

Co-investigatorCIHR2024Project Grant

Principal investigators: Thompson, Jennifer A

Keywords: Adipogenesis; Adipose Tissue; Estrogen; Macrophages; Menopause; Obesity; Sex; Stem Cells

$707,625

Development of a Novel Iron-Based Supplement for Athletes

Principal investigatorNSERC2023Alliance Grants

Principal investigators: Shearer, Jane J

Keywords: Biochemistry; Blood Volume; Fiber; Metabolism; Metabolomics; Metal; Microbiota; Nutrition; Performance; Trace Ion

$166,520

Nutritional Manipulation of the Gut-Brain-Axis in Epilepsy

Nominated PICIHR2022Project Grant

Principal investigators: Shearer, Jane; Scantlebury, Morris

Keywords: Animal Model; Clinical; Metabolism; Neurodevelopment; Nutrition; Pediatric

$699,976

Mechanistic and Metabolic Impacts of Non-Nutritive Sweeteners

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Shearer, Jane

$282,000

Gut Based Modulators of Metabolism

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Shearer, Jane

$28,000

Gut Metabotypes as Biomarkers for Nutrition and Health

Nominated PICIHR2016Team Grant: Biomarkers in Nutrition and Health (BioNH)

Principal investigators: Shearer, Jane

Keywords: Health; Metabolomics; Microbiome; Nutrition

$450,000

Does maternal physical activity affect placenta biology? A multi-tiered approach

Co-investigatorCIHR2015Operating Grant

Principal investigators: Adamo, Kristi B

Keywords: Exosome; Fetal Health; Gene Expression; Metabolome; Nutrient Transport; Physical Activity; Placenta; Pregnancy

$833,864

Guidance of Nutritional Therapeutics and Outcomes by Metabolomics

Nominated PICIHR2012Operating Grant: Programmatic Grants in Food and Health - LOI

Principal investigators: Shearer, Jane; Reimer, Raylene A; Vogel, Hans (Harm) J

Keywords: Chronic Disease; Dietary Fiber; Gene-Nutrirent Interaction; Metabolism; Metabolomics; Model; Obesity; Phenotype; Prediction; Stratification

$10,000

Nutraceutical properties of chlorogenic acid

Principal investigatorNSERC2011Discovery Grants Program - Individual

Principal investigators: Shearer, Jane

$155,000

In Vivo Metabolic Consequences of Stem Cell Therapy for the Diabetic Infarcted Heart.

SupervisorCIHR2010Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Hughey, Curtis C

Keywords: Fatty Acids; Glucose; Insulin Resistance; Metabolism; Mitochondria; Myocardial Infarction; Stem Cell Therapy; Substrate Utilization

$105,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry and Molecular Biology
Microbiology and Infectious Diseases
Medical Genetics
Biology
Interdisciplinary Health Sciences
Medicine
Other

Co-authors at University of Calgary, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Antoine Dufour

Microbiology and Infectious Diseases

3 shared papers, latest 2025

Timothy Shutt

Medical Genetics

3 shared papers, latest 2021

Jennifer Thompson

Biochemistry and Molecular Biology

1 shared papers, latest 2026

Shannon Bainbridge

Interdisciplinary Health Sciences

1 shared papers, latest 2021

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2023

Subject: Prospective PhD student: Metabolism Dear Professor Shearer, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Exploring the Placental Lipidome in Physically Active vs. Inactive Pregnancies." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Development of a Novel Iron-Based Supplement for Athletes" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Jane Shearer

Research

Latest papers

Latest funding

Exploring the Placental Lipidome in Physically Active vs. Inactive Pregnancies.

Early-Life Dietary Protein Source Reshapes Gut Microbiota but Fails to Curtail Diet-Induced Metabolic Syndrome in Young Rats.

SeizureBiomeDB: a unified database of gut microbiome alterations in pediatric and adult epilepsy.

Mitochondrial Dysfunction in Autism and Attention-Deficit/Hyperactivity Disorder: Evidence from Genetic, Biochemical, and Neuroimaging Approaches.

Role of Acid-Sensing Ion Channels 1a in the Regulation of Obesity and the Gut Microbiota.

Cross talk between obesogenic diet and estrogen drives distinct microbiota profiles in ovariectomized mice.

Altered tryptophan metabolism and gut immune crosstalk in hypertensive middle-aged women.

Hippocampal proteomic signatures of the ketogenic diet in a model of infantile epileptic spasms syndrome.

Protocol for measuring mitochondrial respiratory capacity from buccal cell swabs.

Influence of dietary components on the gut microbiota of middle-aged adults: the gut-Mediterranean connection.

Sex and estrogen-dependent cross-talk between macrophages and adipocyte progenitors during adipose remodelling in obesity.

Development of a Novel Iron-Based Supplement for Athletes

Nutritional Manipulation of the Gut-Brain-Axis in Epilepsy

Mechanistic and Metabolic Impacts of Non-Nutritive Sweeteners

Gut Based Modulators of Metabolism

Gut Metabotypes as Biomarkers for Nutrition and Health

Does maternal physical activity affect placenta biology? A multi-tiered approach

Guidance of Nutritional Therapeutics and Outcomes by Metabolomics

Nutraceutical properties of chlorogenic acid

In Vivo Metabolic Consequences of Stem Cell Therapy for the Diabetic Infarcted Heart.

Frequent collaborators

Antoine Dufour

Timothy Shutt

Charlene Elliott

Ning Cheng

Jennifer Thompson

Cory Harris

Yasmin Nasser

Shannon Bainbridge