Lashitew Gedamu, University of Calgary

Research

Read how they describe their research on their University of Calgary profile.

Latest papers

Mode of action of a formulation containing hydrazones and saponins against leishmania spp. Role in mitochondria, proteases and reinfection process.
International journal for parasitology. Drugs and drug resistance · 2020
Protective or Detrimental? Understanding the Role of Host Immunity in Leishmaniasis.
Microorganisms · 2019 · senior author
Immune Response and Protective Efficacy of a Heterologous DNA-Protein Immunization with Leishmania Superoxide Dismutase B1.
BioMed research international · 2017 · senior author

All 16 publications

Latest funding

Epifluorescence microscopy workstation
NSERC · 2017 · Co-investigator
$117,863
Leishmania donovani cathepsin B and antioxidant proteins: role in Leishmania survival and interaction with host macrophages.
NSERC · 2014 · Principal investigator
$205,000
NSERC CREATE in Host-Parasite Interactions (HPI) to model basic biological principles: From research and education to career path
NSERC · 2012 · Co-investigator
$1,650,000

All 17 grants and awards

16 publications.

01

Mode of action of a formulation containing hydrazones and saponins against leishmania spp. Role in mitochondria, proteases and reinfection process.

Upegui Zapata YA, Echeverri F, Quiñones W, Torres F, Nacher M, Rivas LI, Meira CDS, Gedamu L, Escobar G, Archbold R, Vélez ID, Robledo SM

International journal for parasitology. Drugs and drug resistance2020

DOI: 10.1016/j.ijpddr.2020.06.004 PMID: 32734890

02

Protective or Detrimental? Understanding the Role of Host Immunity in Leishmaniasis.

Dos Santos Meira C, Gedamu L

Microorganisms2019Senior author

DOI: 10.3390/microorganisms7120695 PMID: 31847221

03

Immune Response and Protective Efficacy of a Heterologous DNA-Protein Immunization with Leishmania Superoxide Dismutase B1.

Bayih AG, Daifalla NS, Gedamu L

BioMed research international2017Senior author

DOI: 10.1155/2017/2145386 PMID: 29359145

04

Giardia duodenalis Surface Cysteine Proteases Induce Cleavage of the Intestinal Epithelial Cytoskeletal Protein Villin via Myosin Light Chain Kinase

Amol Bhargava, James A. Cotton, Brent R. Dixon, Lashitew Gedamu, Robin M. Yates, André G. Buret

PLoS ONE201568 citationsOpen Access

DOI: 10.1371/journal.pone.0136102 PMID: 26334299

05

Differential Immune Response against Recombinant Leishmania donovani Peroxidoxin 1 and Peroxidoxin 2 Proteins in BALB/c Mice.

Daifalla NS, Bayih AG, Gedamu L

Journal of immunology research2015Senior author

DOI: 10.1155/2015/348401 PMID: 26380320

06

DNA-protein immunization using Leishmania peroxidoxin-1 induces a strong CD4+ T cell response and partially protects mice from cutaneous leishmaniasis: role of fusion murine granulocyte-macrophage colony-stimulating factor DNA adjuvant.

Bayih AG, Daifalla NS, Gedamu L

PLoS neglected tropical diseases2014Senior author

DOI: 10.1371/journal.pntd.0003391 PMID: 25500571

07

A simple technique to enhance the humoral immune response to intracellular protein antigens in genetic immunizations.

Farrell PJ, Kucknoor AS, Iatrou K, Gedamu L

Journal of immunological methods2013Senior author

DOI: 10.1016/j.jim.2012.08.017 PMID: 22964556

08

Cathepsin B gene disruption induced Leishmania donovani proteome remodeling implies cathepsin B role in secretome regulation.

Gerbaba TK, Gedamu L

PloS one2013Senior author

DOI: 10.1371/journal.pone.0079951 PMID: 24244582

09

Leishmania donovani mitochondrial iron superoxide dismutase A is released into the cytosol during miltefosine induced programmed cell death.

Getachew F, Gedamu L

Molecular and biochemical parasitology2012Senior author

DOI: 10.1016/j.molbiopara.2012.01.005 PMID: 22342963

10

Leishmania donovani recombinant iron superoxide dismutase B1 protein in the presence of TLR-based adjuvants induces partial protection of BALB/c mice against Leishmania major infection.

Daifalla NS, Bayih AG, Gedamu L

Experimental parasitology2012Senior author

DOI: 10.1016/j.exppara.2012.05.002 PMID: 22580023

Epifluorescence microscopy workstation

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Muench, Douglas

$117,863

Leishmania donovani cathepsin B and antioxidant proteins: role in Leishmania survival and interaction with host macrophages.

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Gedamu, Lashitew

$205,000

NSERC CREATE in Host-Parasite Interactions (HPI) to model basic biological principles: From research and education to career path

Co-investigatorNSERC2012Collaborative Research and Training Experience

Principal investigators: Buret, Andre

$1,650,000

Identification and characterization of host molecules targeted by leishmania donovani cathepsin B and cathepsin L cysteine proteases during leishmania survival and pathogenesis

Principal investigatorNSERC2009Discovery Grants Program - Individual

Principal investigators: Gedamu, Lashitew

$160,000

Microscope imaging system software

Co-investigatorNSERC2006Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Muench, Douglas

$31,794

Real-time PCR

Co-investigatorNSERC2006Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Habibi, Hamid

$61,432

Spectramax microtitre plate reader system

Co-investigatorNSERC2006Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Buret, Andre

$59,616

Molecular mechanisms of developmentally regulated genes in Leishmania

Principal investigatorNSERC2004Discovery Grants Program - Individual

Principal investigators: Gedamu, Lashitew

$211,450

Fluorescence microscope (with digital camera)

Co-investigatorNSERC2001Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Buret, Andre

$41,328

French press and pressure cells

Co-investigatorNSERC2000Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Huber, Reuben

$26,754

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Frequent collaborators

Department of Biological Sciences
Medicine Dept
Cumming School of Medicine
Veterinary Medicine, Faculty of

Co-authors at University of Calgary, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Joel Dacks

Medicine Dept

2 shared papers, latest 2007

Robin Yates

Veterinary Medicine, Faculty of

1 shared papers, latest 2015

Andre Buret

Cumming School of Medicine

1 shared papers, latest 2015

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Subject: Prospective PhD student Dear Professor Gedamu, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Mode of action of a formulation containing hydrazones and saponins against leishmania spp. Role in mitochondria, proteases and reinfection process." (2020), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]