Michael Tymianski

Research

Acute Neuro-Protection Stroke Thrombolysis

Latest papers

Infarct Evolution on MR-DWI After Thrombectomy in Acute Stroke Patients Randomized to Nerinetide or Placebo: The REPERFUSE-NA1 Study.
Neurology · 2024
Association of Brain Atrophy With Functional Outcome and Recovery Trajectories After Thrombectomy: Post Hoc Analysis of the ESCAPE-NA1 Trial.
Neurology · 2023
Association of Iatrogenic Infarcts With Clinical and Cognitive Outcomes in the Evaluating Neuroprotection in Aneurysm Coiling Therapy Trial.
Neurology · 2022

All 6 publications

Latest funding

A Multicentre, Randomized, Double-blinded, Placebo-controlled, Parallel Group, Single-dose Design to Determine the Efficacy and Safety of NoNO-42 in Participants with Acute Ischemic Stroke Selected for Thrombolysis
CIHR · 2023 · Principal investigator
$4,048,545
A Multicentre, Randomized, Double-blinded, Placebo-controlled, Parallel Group, Single-dose Design to Determine the Efficacy and Safety of NoNO-42 in Participants with Acute Ischemic Stroke Selected for Thrombolysis
CIHR · 2023 · Principal investigator
$1,012,136

All 2 grants and awards

6 publications.

01

Infarct Evolution on MR-DWI After Thrombectomy in Acute Stroke Patients Randomized to Nerinetide or Placebo: The REPERFUSE-NA1 Study.

Fladt J, Guo J, Specht JL, Wang M, Chan LL, Mctaggart R, Buck BH, Aviv R, Swartz RH, Field TS, Tarpley J, Shah R, Goyal M, Tymianski M, Hill MD, Demchuk A, d'Esterre C, Barber P

Neurology2024

DOI: 10.1212/wnl.0000000000207976 PMID: 38165335

02

Association of Brain Atrophy With Functional Outcome and Recovery Trajectories After Thrombectomy: Post Hoc Analysis of the ESCAPE-NA1 Trial.

Benali F, Fladt J, Jaroenngarmsamer T, Bala F, Singh N, Ospel JM, Tymianski M, Hill MD, Goyal M, Ganesh A

Neurology2023

DOI: 10.1212/wnl.0000000000207700 PMID: 37591777

03

Association of Iatrogenic Infarcts With Clinical and Cognitive Outcomes in the Evaluating Neuroprotection in Aneurysm Coiling Therapy Trial.

Ganesh A, Goyal M, Wilson AT, Ospel JM, Demchuk AM, Mikulis D, Poublanc J, Krings T, Anderson R, Tymianski M, Hill MD, ENACT Trial Investigators

Neurology2022

DOI: 10.1212/wnl.0000000000200111 PMID: 35169007

04

Radiologic Patterns of Intracranial Hemorrhage and Clinical Outcome after Endovascular Treatment in Acute Ischemic Stroke: Results from the ESCAPE-NA1 Trial.

Ospel JM, Qiu W, Menon BK, Mayank A, Demchuk A, McTaggart R, Nogueira RG, Poppe AY, Jayaraman M, Buck B, Haussen D, Roy D, Joshi M, Zerna C, Almekhlafi M, Tymianski M, Hill MD, Goyal M, ESCAPE-NA1 Investigators

Radiology2021

DOI: 10.1148/radiol.2021204560 PMID: 34060942

05

A Detailed Analysis of Infarct Patterns and Volumes at 24-hour Noncontrast CT and Diffusion-weighted MRI in Acute Ischemic Stroke Due to Large Vessel Occlusion: Results from the ESCAPE-NA1 Trial.

Ospel JM, Menon BK, Qiu W, Kashani N, Mayank A, Singh N, Cimflova P, Marko M, Nogueira RG, McTaggart RA, Demchuk AM, Poppe AY, Zerna C, Joshi M, Almekhlafi MA, Haussen D, Cutting S, Coutts SB, Roy D, Rohr A, Iancu D, Tymianski M, Hill MD, Goyal M, ESCAPE-NA1 Investigators

Radiology2021

DOI: 10.1148/radiol.2021203964 PMID: 33973838

06

Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial.

Hill MD, Martin RH, Mikulis D, Wong JH, Silver FL, Terbrugge KG, Milot G, Clark WM, Macdonald RL, Kelly ME, Boulton M, Fleetwood I, McDougall C, Gunnarsson T, Chow M, Lum C, Dodd R, Poublanc J, Krings T, Demchuk AM, Goyal M, Anderson R, Bishop J, Garman D, Tymianski M, ENACT trial investigators

The Lancet. Neurology2012Senior author

DOI: 10.1016/s1474-4422(12)70225-9 PMID: 23051991

A Multicentre, Randomized, Double-blinded, Placebo-controlled, Parallel Group, Single-dose Design to Determine the Efficacy and Safety of NoNO-42 in Participants with Acute Ischemic Stroke Selected for Thrombolysis

Principal investigatorCIHR2023Operating Grant: Clinical Trials Projects

Principal investigators: Menon, Bijoy K; Christenson, James M; Hill, Michael D; Singh, Nishita; Swartz, Richard; Tymianski, Michael

Keywords: Acute; Neuro-Protection; Stroke; Thrombolysis

$4,048,545

A Multicentre, Randomized, Double-blinded, Placebo-controlled, Parallel Group, Single-dose Design to Determine the Efficacy and Safety of NoNO-42 in Participants with Acute Ischemic Stroke Selected for Thrombolysis

Principal investigatorCIHR2023Operating Grant: Clinical Trials Projects - Indirect Costs

Principal investigators: Menon, Bijoy K; Christenson, James M; Hill, Michael D; Singh, Nishita; Swartz, Richard; Tymianski, Michael

Keywords: Acute; Neuro-Protection; Stroke; Thrombolysis

$1,012,136

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Clinical Neurosciences
Medical Imaging
Diagnostic Radiology
Neurology and Neurosciences
Medicine
Other

1 shared papers, latest 2024

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Acute Dear Professor Tymianski, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Infarct Evolution on MR-DWI After Thrombectomy in Acute Stroke Patients Randomized to Nerinetide or Placebo: The REPERFUSE-NA1 Study." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "A Multicentre, Randomized, Double-blinded, Placebo-controlled, Parallel Group, Single-dose Design to Determine the Efficacy and Safety of NoNO-42 in Participants with Acute Ischemic Stroke Selected for Thrombolysis" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]