Faculty profile

Robert Newton

ResearcherPhysiology and PharmacologyUniversity of Calgary

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Calgary directory, so their courses may be missing. Find their university profile.

Robert Newton

Researcher

Physiology and Pharmacology

Health Sciences

University of Calgary

Calgary, Alberta, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
9 publications in the last five years, latest in 2025.
Senior (last) author on 7 recent papers, a sign of leading a research group.
Principal investigator on 6 research grants (4 CIHR, 2 NSERC), most recently in 2023.
Supervised 1 trainee who won CIHR awards, most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Citations

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Gene Regulation Inflammation Asthma Regulation Gene Expression Glucocorticoid Action Glucocorticoid Resistance Molecular Pharmacology

Latest papers

Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB.
PloS one · 2025 · senior author
Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid.
Molecular pharmacology · 2025 · senior author
NF-κB-dependent GR cistrome redistribution recruits GR to inflammatory genes but correlates with lesser glucocorticoid-mediated repression.
iScience · 2025 · senior author

All 58 publications

Latest funding

Unraveling the role of extracellular matrix dysregulation in age-related fibrotic and inflammatory pulmonary disease
CIHR · 2023 · Supervisor
$180,000
Biased Agonism Mediated by the Glucocorticoid Receptor
CIHR · 2023 · Co-investigator
$852,976
Dynamic effects of inflammatory cytokines on signaling and gene expression: Modulation and priming of epithelial cell responses
NSERC · 2023 · Principal investigator
$80,000

All 13 grants and awards

58 publications.

Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB.

Necker-Brown A, Mostafa MM, Georgescu A, Thorne AJ, Chandramohan P, Kooi C, Kalyanaraman K, Gao A, Bansal A, Sasse SK, Gerber AN, Leigh R, Newton R

PloS one2025Senior author

DOI: 10.1371/journal.pone.0329244 PMID: 41359631

Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid.

Thorne AJ, Gao A, Necker-Brown A, Bansal A, Kalyanaraman K, Chandramohan P, Sasse SK, Gerber AN, Mostafa MM, Newton R

Molecular pharmacology2025Senior author

DOI: 10.1016/j.molpha.2025.100073 PMID: 40972476

NF-κB-dependent GR cistrome redistribution recruits GR to inflammatory genes but correlates with lesser glucocorticoid-mediated repression.

Mostafa MM, Necker-Brown A, Gao A, Thorne AJ, Bansal A, Swift L, Maj AM, Sasse SK, Colarusso P, Gerber AN, Newton R

iScience2025Senior author

DOI: 10.1016/j.isci.2025.114206 PMID: 41488369

Genomic crosstalk between carbachol, a muscarinic receptor agonist, and the long-acting β2-adrenoceptor agonist, indacaterol, in human airway epithelial cells.

Jayasinghe V, Joshi R, Joshi T, Paracha TU, Kooi C, Mostafa MM, Bauer CMT, Charlton SJ, Iartchouk O, Maillet A, Morris MK, Ruda VM, Sandham DA, Wang Y, Newton R, Giembycz MA

The Journal of pharmacology and experimental therapeutics2025

DOI: 10.1016/j.jpet.2025.103579 PMID: 40305997

Comparison of the Genomic Activity of an EP4-Receptor and β2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-Dependent Gene Expression.

Joshi R, Paracha TU, Mostafa MM, Thorne AJ, Jayasinghe V, Yan D, Hamed O, Newton R, Giembycz MA

The Journal of pharmacology and experimental therapeutics2024

DOI: 10.1124/jpet.124.002226 PMID: 39060164

Inducible gene expression of IκB-kinase ε is dependent on nuclear factor-κB in human pulmonary epithelial cells.

Necker-Brown A, Kooi C, Thorne AJ, Bansal A, Mostafa MM, Chandramohan P, Gao A, Kalyanaraman K, Milani A, Gill S, Georgescu A, Sasse SK, Gerber AN, Leigh R, Newton R

The Biochemical journal2024Senior author

DOI: 10.1042/bcj20230461 PMID: 38941070

Synergy between Interleukin-1β, Interferon-γ, and Glucocorticoids to Induce TLR2 Expression Involves NF-κB, STAT1, and the Glucocorticoid Receptor.

Bansal A, Kooi C, Kalyanaraman K, Gill S, Thorne A, Chandramohan P, Necker-Brown A, Mostafa MM, Milani A, Leigh R, Newton R

Molecular pharmacology2023Senior author

DOI: 10.1124/molpharm.123.000740 PMID: 37863662

Differential regulation of BIRC2 and BIRC3 expression by inflammatory cytokines and glucocorticoids in pulmonary epithelial cells.

Thorne A, Bansal A, Necker-Brown A, Mostafa MM, Gao A, Georgescu A, Kooi C, Leigh R, Newton R

PloS one2023Senior author

DOI: 10.1371/journal.pone.0286783 PMID: 37289679

Interplay between nuclear factor-κB, p38 MAPK, and glucocorticoid receptor signaling synergistically induces functional TLR2 in lung epithelial cells.

Bansal A, Mostafa MM, Kooi C, Sasse SK, Michi AN, Shah SV, Leigh R, Gerber AN, Newton R

The Journal of biological chemistry2022Senior author

DOI: 10.1016/j.jbc.2022.101747 PMID: 35189144

Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid/Long-Acting β 2-Adrenoceptor Agonist Combination Therapy in Asthma.

Mostafa MM, Rider CF, Wathugala ND, Leigh R, Giembycz MA, Newton R

Molecular pharmacology2021Senior author

DOI: 10.1124/molpharm.120.000146 PMID: 33376135

Unraveling the role of extracellular matrix dysregulation in age-related fibrotic and inflammatory pulmonary disease

SupervisorCIHR2023CIHR REDI Early Career Transition Award - Infectious Disease and Immune System

Principal investigators: Kai, FuiBoon

Keywords: Actomyosin Network; Age-Related Diseases; Biophysical Properties Of Cells; Extracellular Matrix; Idiopathic Pulmonary Fibrosis; Inflammation; Mechanosignaling; Tissue Stiffness

$180,000

Biased Agonism Mediated by the Glucocorticoid Receptor

Co-investigatorCIHR2023Project Grant

Principal investigators: Giembycz, Mark A

Keywords: Biased Agonism; Glucocorticoid Receptor; Molecular Pharmacology; Pharmacodynamics

$852,976

Dynamic effects of inflammatory cytokines on signaling and gene expression: Modulation and priming of epithelial cell responses

Principal investigatorNSERC2023Discovery Grants Program - Individual

Principal investigators: Newton, Robert

Keywords: cytokines; epithelial cell; gene expression; gene regulation; inflammation; NF-kappaB; signaling; transcription

$80,000

Biased Agonism Mediated by the Glucocorticoid Receptor

Co-investigatorCIHR2022Project Grant

Principal investigators: Giembycz, Mark A

Keywords: Biased Agonism; Glucocorticoid Receptor; Molecular Pharmacology; Pharmacodynamics

$100,000

Understanding glucocorticoid resistance in inflammatory disease

Nominated PICIHR2021Project Grant

Principal investigators: Newton, Robert

Keywords: Gene Regulation; Glucocorticoid Action; Glucocorticoid Resistance; Inflammation; Molecular Pharmacology; Nuclear Hormone Receptor

$879,750

Towards an improved understanding of myometrial quiescence and contraction: Differential regulation via G-protein coupled receptors (GPCRs) and control by regulator of G-protein signaling 2 (RGS2)

Co-investigatorCIHR2020Project Grant

Principal investigators: Slater, Donna M

Keywords: G-Protein Coupled Receptors; Molecular Knockdown/Knockout; Molecular Physiology; Myometrium; Parturition; Preterm Labour; Primary Myometrial Cell Culture; Prostaglandin Pathway; Regulator Of G Protein Signaling; Uterine Contractility

$546,976

Molecular mechanisms underlying the clinical efficacy of inhaled corticosteroid/long-acting beta2-adrenoceptor agonist combination therapies in asthma

Nominated PICIHR2017Project Grant

Principal investigators: Newton, Robert

Keywords: Asthma; Beta2-Adrenoceptor; Glucocorticoid; Regulation; Signal Transduction; Therapy; Transcription

$1,078,650

Does traffic-related air pollution reduce the effectiveness of corticosteroids in asthma treatment?

Co-investigatorCIHR2017Project Grant

Principal investigators: Carlsten, Christopher

Keywords: Asthma; Controlled Human Exposures; Environmental Determinants Of Lung Disease; Epigenetics; Gene Expression; Inhaled Corticosteroids; Proteomics; Public Health; Traffic-Related Air Pollution; Transcriptomics

$673,200

Molecular mechanisms underlying the enhanced efficacy of inhaled corticosteroid/long-acting beta2-adrenoceptor agonist combinations used in asthma

Nominated PICIHR2016Project Grant

Principal investigators: Newton, Robert

Keywords: Gene Expression; Glucocorticoids / Corticosteroids; Long-Acting Beta2-Agonists; Regulation; Transcriptional Control

$100,000

Transcriptional programmes downstream of the activated glucocorticoid receptor

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Newton, Robert

$198,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2023

Subject: Prospective PhD student: Gene Regulation Dear Professor Newton, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Dynamic effects of inflammatory cytokines on signaling and gene expression: Modulation and priming of epithelial cell responses" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

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Robert Newton

Research

Latest papers

Latest funding

Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB.

Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid.

NF-κB-dependent GR cistrome redistribution recruits GR to inflammatory genes but correlates with lesser glucocorticoid-mediated repression.

Genomic crosstalk between carbachol, a muscarinic receptor agonist, and the long-acting β2-adrenoceptor agonist, indacaterol, in human airway epithelial cells.

Comparison of the Genomic Activity of an EP4-Receptor and β2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-Dependent Gene Expression.

Inducible gene expression of IκB-kinase ε is dependent on nuclear factor-κB in human pulmonary epithelial cells.

Synergy between Interleukin-1β, Interferon-γ, and Glucocorticoids to Induce TLR2 Expression Involves NF-κB, STAT1, and the Glucocorticoid Receptor.

Differential regulation of BIRC2 and BIRC3 expression by inflammatory cytokines and glucocorticoids in pulmonary epithelial cells.

Interplay between nuclear factor-κB, p38 MAPK, and glucocorticoid receptor signaling synergistically induces functional TLR2 in lung epithelial cells.

Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid/Long-Acting β 2-Adrenoceptor Agonist Combination Therapy in Asthma.

Unraveling the role of extracellular matrix dysregulation in age-related fibrotic and inflammatory pulmonary disease

Biased Agonism Mediated by the Glucocorticoid Receptor

Dynamic effects of inflammatory cytokines on signaling and gene expression: Modulation and priming of epithelial cell responses

Biased Agonism Mediated by the Glucocorticoid Receptor

Understanding glucocorticoid resistance in inflammatory disease

Towards an improved understanding of myometrial quiescence and contraction: Differential regulation via G-protein coupled receptors (GPCRs) and control by regulator of G-protein signaling 2 (RGS2)

Molecular mechanisms underlying the clinical efficacy of inhaled corticosteroid/long-acting beta2-adrenoceptor agonist combination therapies in asthma

Does traffic-related air pollution reduce the effectiveness of corticosteroids in asthma treatment?

Molecular mechanisms underlying the enhanced efficacy of inhaled corticosteroid/long-acting beta2-adrenoceptor agonist combinations used in asthma

Transcriptional programmes downstream of the activated glucocorticoid receptor

Frequent collaborators

Richard Leigh

David Proud

Jeremy Hirota

Robert Newton

Research

Latest papers

Latest funding

Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-&#x3ba;B.

Differential RELA and GR recruitment to the BIRC3/BIRC2 locus: Molecular insight as to combinatorial regulation by proinflammatory cytokines and glucocorticoid.

NF-&#x3ba;B-dependent GR cistrome redistribution recruits GR to inflammatory genes but correlates with lesser glucocorticoid-mediated repression.

Genomic crosstalk between carbachol, a muscarinic receptor agonist, and the long-acting &#x3b2;2-adrenoceptor agonist, indacaterol, in human airway epithelial cells.

Comparison of the Genomic Activity of an EP4-Receptor and &#x3b2;2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-Dependent Gene Expression.

Inducible gene expression of I&#x3ba;B-kinase &#x3b5; is dependent on nuclear factor-&#x3ba;B in human pulmonary epithelial cells.

Synergy between Interleukin-1&#x3b2;, Interferon-&#x3b3;, and Glucocorticoids to Induce TLR2 Expression Involves NF-&#x3ba;B, STAT1, and the Glucocorticoid Receptor.

Differential regulation of BIRC2 and BIRC3 expression by inflammatory cytokines and glucocorticoids in pulmonary epithelial cells.

Interplay between nuclear factor-&#x3ba;B, p38 MAPK, and glucocorticoid receptor signaling synergistically induces functional TLR2 in lung epithelial cells.

Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid/Long-Acting &#x3b2; 2-Adrenoceptor Agonist Combination Therapy in Asthma.

Dynamic effects of inflammatory cytokines on signaling and gene expression: Modulation and priming of epithelial cell responses

Transcriptional programmes downstream of the activated glucocorticoid receptor

Frequent collaborators

Richard Leigh

David Proud

Jeremy Hirota

Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB.

NF-κB-dependent GR cistrome redistribution recruits GR to inflammatory genes but correlates with lesser glucocorticoid-mediated repression.

Genomic crosstalk between carbachol, a muscarinic receptor agonist, and the long-acting β2-adrenoceptor agonist, indacaterol, in human airway epithelial cells.

Comparison of the Genomic Activity of an EP4-Receptor and β2-Adrenoceptor Agonist in BEAS-2B Human Bronchial Epithelial Cells: In Search of Compartmentalized, cAMP-Dependent Gene Expression.

Inducible gene expression of IκB-kinase ε is dependent on nuclear factor-κB in human pulmonary epithelial cells.

Synergy between Interleukin-1β, Interferon-γ, and Glucocorticoids to Induce TLR2 Expression Involves NF-κB, STAT1, and the Glucocorticoid Receptor.

Interplay between nuclear factor-κB, p38 MAPK, and glucocorticoid receptor signaling synergistically induces functional TLR2 in lung epithelial cells.

Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid/Long-Acting β 2-Adrenoceptor Agonist Combination Therapy in Asthma.