Jenifer Thewalt, Simon Fraser University

Research

Ceramide Lipid nanoparticles: phases of components Lipid phase behaviour Membrane structure Non-lamellar phases Phosphatidylcholine Solid state deuterium NMR Sphingomyelin

Latest papers

Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.
The Journal of general physiology · 2021
Link between Fluorescent Probe Partitioning and Molecular Order of Liquid Ordered-Liquid Disordered Membranes.
The journal of physical chemistry. B · 2017 · senior author
Biophysical experiments and simulation in nanoparticle-based drug delivery systems.
Journal of drug targeting · 2016 · first author

All 6 publications

Latest funding

Domains in Biologically Relevant Lipid Membranes
NSERC · 2019 · Principal investigator
$216,000
Careers in biophysics-Trainee Symposium
NSERC · 2018 · Principal investigator
$4,700
Development of the next generation of lipid nanoparticles for gene therapy
NSERC · 2014 · Co-investigator
$411,437

All 12 grants and awards

6 publications.

01

Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.

Ghovanloo MR, Choudhury K, Bandaru TS, Fouda MA, Rayani K, Rusinova R, Phaterpekar T, Nelkenbrecher K, Watkins AR, Poburko D, Thewalt J, Andersen OS, Delemotte L, Goodchild SJ, Ruben PC

The Journal of general physiology2021

DOI: 10.1085/jgp.202012701 PMID: 33836525

02

Link between Fluorescent Probe Partitioning and Molecular Order of Liquid Ordered-Liquid Disordered Membranes.

Leung SS, Thewalt J

The journal of physical chemistry. B2017Senior author

DOI: 10.1021/acs.jpcb.6b09325 PMID: 28145724

03

Biophysical experiments and simulation in nanoparticle-based drug delivery systems.

Thewalt J, Tieleman DP

Journal of drug targeting2016First author

DOI: 10.1080/1061186x.2016.1221957 PMID: 27608728

04

Insights into sphingolipid miscibility: separate observation of sphingomyelin and ceramide N-acyl chain melting.

Leung SS, Busto JV, Keyvanloo A, Goñi FM, Thewalt J

Biophysical journal2012Senior author

DOI: 10.1016/j.bpj.2012.10.041 PMID: 23260048

05

Phase behavior of an equimolar mixture of N-palmitoyl-D-erythro-sphingosine, cholesterol, and palmitic acid, a mixture with optimized hydrophobic matching.

Brief E, Kwak S, Cheng JT, Kitson N, Thewalt J, Lafleur M

Langmuir : the ACS journal of surfaces and colloids2009

DOI: 10.1021/la9003643 PMID: 19563230

06

The effect of ergosterol on dipalmitoylphosphatidylcholine bilayers: a deuterium NMR and calorimetric study.

Hsueh YW, Gilbert K, Trandum C, Zuckermann M, Thewalt J

Biophysical journal2005Senior author

DOI: 10.1529/biophysj.104.051375 PMID: 15596499

Domains in Biologically Relevant Lipid Membranes

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Thewalt, Jenifer

Keywords: Ceramide; Lipid nanoparticles: phases of components; Lipid phase behaviour; Membrane structure; Non-lamellar phases; Phosphatidylcholine; Solid state deuterium NMR; Sphingomyelin; Sterol (eg cholesterol); X-ray scattering

$216,000

Careers in biophysics-Trainee Symposium

Principal investigatorNSERC2018Connect Grants Level 2

Principal investigators: Thewalt, Jenifer

$4,700

Development of the next generation of lipid nanoparticles for gene therapy

Co-investigatorNSERC2014Strategic Projects - Group

Principal investigators: Tieleman, Peter

$411,437

Domains in Biologically Relevant Lipid Membranes

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Thewalt, Jenifer

$175,000

Differential scanning calorimeter

Co-investigatorNSERC2010Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Williams, Vance

$74,927

Domains in biologically relevant lipid membranes

Principal investigatorNSERC2009Discovery Grants Program - Individual

Principal investigators: Thewalt, Jenifer

$160,000

Domains in membranes & peptide interactions with cubic phase lipids

Principal investigatorNSERC2004Discovery Grants Program - Individual

Principal investigators: Thewalt, Jenifer

$156,950

SFU chemistry department 500 MHz NMR spectrometer

Co-investigatorNSERC2002Research Tools and Instruments - Category 3 (>$325,000)

Principal investigators: Pinto, Mario

$510

Lipid phase behavior: membrane domains & membrane protein structure determination

Principal investigatorNSERC2000Discovery Grants Program - Individual

Principal investigators: Thewalt, Jenifer

$116,000

Nmr spectrometer completion

Principal investigatorNSERC1996Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Thewalt, Jenifer

$46,670

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Damon Poburko

Biomedical Physiology & Kinesiology

1 shared papers, latest 2021

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2019

Subject: Prospective PhD student: Ceramide Dear Professor Thewalt, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity." (2021), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Domains in Biologically Relevant Lipid Membranes" (2019), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]