Jinko Graham, Simon Fraser University

Research

genetic mapping genetic linkage and association high-dimensional phenotypes gene genealogies the coalescent with recombination clustering posterior distributions markov-chain monte-carlo samplers

Latest papers

Statistics to prioritize rare variants in family-based sequencing studies with disease subtypes.
Genetic epidemiology · 2024 · senior author
Association Between HLA-DPB1 and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Children.
Arthritis & rheumatology (Hoboken, N.J.) · 2023
An exploration of linkage fine-mapping on sequences from case-control studies.
Genetic epidemiology · 2023 · senior author

All 23 publications

Latest funding

Statistical Methods to Map Disease Genes in Populations
NSERC · 2018 · Principal investigator
$140,000
New and efficient approaches to Markov chain Monte Carlo sampling of gene genealogies conditional on observed genetic data
NSERC · 2013 · Principal investigator
$75,000
Identification of Genetic Factors for Familial Lymphoid Cancers
CIHR · 2013 · Co-investigator
$799,698

All 16 grants and awards

23 publications.

01

Statistics to prioritize rare variants in family-based sequencing studies with disease subtypes.

Nieuwoudt C, Farooq FB, Brooks-Wilson A, Bureau A, Graham J

Genetic epidemiology2024Senior author

DOI: 10.1002/gepi.22579 PMID: 38940260

02

Association Between HLA-DPB1 and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Children.

Gibson KM, Drögemöller BI, Foell D, Benseler SM, Graham J, Hancock REW, Luqmani RA, Cabral DA, Brown KL, Ross CJ, PedVas Investigator's Network

Arthritis & rheumatology (Hoboken, N.J.)2023

DOI: 10.1002/art.42423 PMID: 36530128

03

An exploration of linkage fine-mapping on sequences from case-control studies.

Nickchi P, Karunarathna C, Graham J

Genetic epidemiology2023Senior author

DOI: 10.1002/gepi.22502 PMID: 36047334

04

Inference of gene-environment interaction from heterogeneous case-parent trios.

Ratnasekera P, Graham J, McNeney B

Frontiers in genetics2022

DOI: 10.3389/fgene.2022.1065568 PMID: 36685810

05

Datasets for a simulated family-based exome-sequencing study.

Epasinghege Dona N, Graham J

Data in brief2022Senior author

DOI: 10.1016/j.dib.2022.108311 PMID: 35928588

06

Different Disease Endotypes in Phenotypically Similar Vasculitides Affecting Small-to-Medium Sized Blood Vessels.

Gill EE, Smith ML, Gibson KM, Morishita KA, Lee AHY, Falsafi R, Graham J, Foell D, Benseler SM, Ross CJ, Luqmani RA, Cabral DA, Hancock REW, Brown KL, PedVas Initiative Investigators

Frontiers in immunology2021

DOI: 10.3389/fimmu.2021.638571 PMID: 33692808

07

SimRVSequences: an R package to simulate genetic sequence data for pedigrees.

Nieuwoudt C, Brooks-Wilson A, Graham J

Bioinformatics (Oxford, England)2020Senior author

DOI: 10.1093/bioinformatics/btz881 PMID: 31764964

08

perfectphyloR: An R package for reconstructing perfect phylogenies.

Karunarathna CB, Graham J

BMC bioinformatics2019Senior author

DOI: 10.1186/s12859-019-3313-4 PMID: 31870286

09

Identification of Novel Adenosine Deaminase 2 Gene Variants and Varied Clinical Phenotype in Pediatric Vasculitis.

Gibson KM, Morishita KA, Dancey P, Moorehead P, Drögemöller B, Han X, Graham J, Hancock REW, Foell D, Benseler S, Luqmani R, Yeung RSM, Shenoi S, Bohm M, Rosenberg AM, Ross CJ, Cabral DA, Brown KL, PedVas Investigators Network

Arthritis & rheumatology (Hoboken, N.J.)2019

DOI: 10.1002/art.40913 PMID: 31008556

10

The Contribution Plot: Decomposition and Graphical Display of the RV Coefficient, with Application to Genetic and Brain Imaging Biomarkers of Alzheimer's Disease.

Choi J, Lu D, Beg MF, Graham J, McNeney B, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)

Human heredity2019

DOI: 10.1159/000501334 PMID: 31430752

Statistical Methods to Map Disease Genes in Populations

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Graham, Jinko

Keywords: genetic mapping; genetic linkage and association; high-dimensional phenotypes; gene genealogies; the coalescent with recombination; clustering; posterior distributions; markov-chain monte-carlo samplers; particle-marginal metropolis-hastings samplers; phenotypic and genealogical similarities

$140,000

New and efficient approaches to Markov chain Monte Carlo sampling of gene genealogies conditional on observed genetic data

Principal investigatorNSERC2013Discovery Grants Program - Individual

Principal investigators: Graham, Jinko

$75,000

Identification of Genetic Factors for Familial Lymphoid Cancers

Co-investigatorCIHR2013Operating Grant

Principal investigators: Brooks-Wilson, Angela R

Keywords: Exome Sequencing; Familial Cancer; Hodgkin Lymphoma; Lymphoid Cancer; Lymphoid Leukemia; Lymphoma; Multiple Myeloma; Next Generation Sequencing; Non-Hodgkin Lymphoma

$799,698

Computer network enhancement

Co-investigatorNSERC2011Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: McNeney, WilliamBradley(Brad)

$21,507

MPrime Network (formerly MITACS) / Réseau MPrime (autrefois MITACS)

Co-investigatorNSERC2009Networks of Centres of Excellence

Principal investigators: Gupta, Arvind

$12,553,000

Computer network enhancement

Co-investigatorNSERC2007Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: McNeney, William

$57,097

Improved statistical methods for identifying generic risk factors underlying complex diseases

Principal investigatorNSERC2007Discovery Grants Program - Individual

Principal investigators: Graham, Jinko

$100,000

Computing network enhancement

Co-investigatorNSERC2005Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Lockhart, Richard

$8,000

Mathematics of Information Technology and Complex Systems/Les mathématiques des technologies de l'information et des systèmes complexes

Co-investigatorNSERC2005Networks of Centres of Excellence

Principal investigators: Gupta, Arvind

$17,419,000

Computing network enhancement

Co-investigatorNSERC2003Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Lockhart, Richard

$10,696

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Statistics and Actuarial Science
Statistics & Actuarial Science
Genome Sciences Centre
Pharmsci
Médecine sociale et préventive
Mathematics and Statistics
Department of Pediatrics

Co-authors at Simon Fraser University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Brad McNeney

Statistics & Actuarial Science

8 shared papers, latest 2022

Angela Brooks-Wilson

Genome Sciences Centre

5 shared papers, latest 2024

Ronald Reid

Pharmsci

2 shared papers, latest 2013

Alexandre Bureau

Médecine sociale et préventive

1 shared papers, latest 2024

Susanne Benseler

Department of Pediatrics

1 shared papers, latest 2019

Mary Lesperance

Mathematics and Statistics

1 shared papers, latest 2017

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Subject: Prospective PhD student: genetic mapping Dear Professor Graham, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Statistics to prioritize rare variants in family-based sequencing studies with disease subtypes." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]