Michel Leroux, Simon Fraser University

Research

C. Elegans Human Disease Ciliopathy Cell Signalling Cell Biology Cilia Ciliogenesis Genetics

Latest papers

Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects.
American journal of human genetics · 2018

All 1 publications

Latest funding

Regulation of the intraflagellar transport pathway, a mutational hotspot required for cilium formation and maintenance
CIHR · 2017 · Nominated PI
$745,875
Cell biology of an evolutionarily conserved ciliary compartment essential for cellular signalling
CIHR · 2015 · Nominated PI
$690,094
Functional genomics of cilium formation and maintenance
CIHR · 2012 · Nominated PI
$621,940

All 11 grants and awards

1 publications.

01

Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects.

Bonnefoy S, Watson CM, Kernohan KD, Lemos M, Hutchinson S, Poulter JA, Crinnion LA, Berry I, Simmonds J, Vasudevan P, O'Callaghan C, Hirst RA, Rutman A, Huang L, Hartley T, Grynspan D, Moya E, Li C, Carr IM, Bonthron DT, Leroux M, Care4Rare Canada Consortium, Boycott KM, Bastin P, Sheridan EG

American journal of human genetics2018

DOI: 10.1016/j.ajhg.2018.10.003 PMID: 30388400

Regulation of the intraflagellar transport pathway, a mutational hotspot required for cilium formation and maintenance

Nominated PICIHR2017Project Grant

Principal investigators: Leroux, Michel R

Keywords: C. Elegans; Cell Signalling; Ciliopathy; Cilium; Development; Human Disease; Intraflagellar Transport (Ift); Mechanism; Sensory Physiology

$745,875

Cell biology of an evolutionarily conserved ciliary compartment essential for cellular signalling

Nominated PICIHR2015Operating Grant

Principal investigators: Leroux, Michel R

Keywords: C. Elegans; Cell Biology; Cell Signalling; Cilia; Ciliogenesis; Genetics; Genomics; Human Disease; Meckel Syndrome; Transition Zone

$690,094

Functional genomics of cilium formation and maintenance

Nominated PICIHR2012Operating Grant

Principal investigators: Leroux, Michel R

Keywords: Bardet-Biedl Syndrome; C. Elegans; Cell Biology; Cilia; Ciliogenesis; Ciliopathy; Genetics; Genomics; Human Disease; Ift

$621,940

Dissection of signaling roles of motility-associated ciliary genes in Caenorhabditis elegans

SupervisorCIHR2012Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Loucks, Catrina M

Keywords: Caenorhabditis Elegans; Cilia; Human Disease; Motility; Signaling

$105,000

Dissecting the molecular and cellular links between cilia, cGMP signaling, physiology and disease

Nominated PICIHR2009Operating Grant

Principal investigators: Leroux, Michel R

Keywords: Bardet-Biedl Syndrome; Cgmp Signaling; Cilia; Disease; Satiety/Obesity; Sensory Perception

$536,450

Ultra-sensitive camera for live cell imaging under low-light conditions

Co-investigatorNSERC2007Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Hutter, Harald

$43,975

A HPLC system for small molecule and nucleic acid purification

Co-investigatorNSERC2005Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Unrau, Peter

$78,463

Preparative centrifuge for molecular biology

Co-investigatorNSERC2003Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Smith, Michael

$98,605

SFU chemistry department 500 MHz NMR spectrometer

Co-investigatorNSERC2002Research Tools and Instruments - Category 3 (>$325,000)

Principal investigators: Pinto, Mario

$510

Structure-function studies on a novel molecular chaperone

Principal investigatorNSERC2001Discovery Grants Program - Individual

Principal investigators: Leroux, Michel

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Molecular Biology and Biochemistry
Nutritional Sciences
Other

Co-authors at Simon Fraser University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

David Grynspan

Nutritional Sciences

1 shared papers, latest 2018

Taila Hartley

Faculty

1 shared papers, latest 2018

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Subject: Prospective PhD student: C. Elegans Dear Professor Leroux, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Biallelic Mutations in LRRC56, Encoding a Protein Associated with Intraflagellar Transport, Cause Mucociliary Clearance and Laterality Defects." (2018), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]