Faculty profile
Andis Klegeris
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Research
Latest papers
Microbiome-driven alterations in tryptophan metabolism contribute to behavioral comorbidities in the Muc2 knockout mouse model of chronic colitis.
Gut microbes · 2026
Extracellular matrix-derived matrikines as emerging modulators of neuroinflammation and central nervous system signaling.
Reviews in the neurosciences · 2026 · senior author
Matrikines as emerging mediators in gut-brain communication: Bridging gastrointestinal remodeling and function in the central nervous system.
Neural regeneration research · 2026 · first author
Latest funding
- $282,000
Regulation of astrocyte phagocytosis and other physiological functions by molecules endogenous to the central nervous system
NSERC · 2020 · Principal investigator
- $25,000
Therapeutic interventions that alter colitogenic microbiota
CIHR · 2018 · Co-investigator
- $126,314
Ultracentrifuge for Subcellular Fractionation
NSERC · 2015 · Co-investigator
97 publications.
Microbiome-driven alterations in tryptophan metabolism contribute to behavioral comorbidities in the Muc2 knockout mouse model of chronic colitis.
Josephson JK, Barnett JA, Yuzbashian E, Verdugo-Meza A, Murch SJ, Wenzel TJ, Klegeris A, Sharkey KA, Gibson DL
Extracellular matrix-derived matrikines as emerging modulators of neuroinflammation and central nervous system signaling.
Creed EC, Beckedorf M, Yudin SCY, Deyholos FL, Klegeris A
Matrikines as emerging mediators in gut-brain communication: Bridging gastrointestinal remodeling and function in the central nervous system.
Klegeris A
Extracellular Matrix-Derived Matrikines: Circulating Peptides as Candidate Mediators of Lung-to-Brain Signaling.
Klegeris A
Mitochondrial damage-associated molecular patterns: Neuroimmunomodulators in central nervous system pathophysiology.
Brooks NAH, Riar I, Klegeris A
Extracellular Succinate Modulates Neuroimmune Responses in a Murine Microglial Cell Line.
Yudin SCY, Day K, Scott EY, Patel MN, Islam H, Klegeris A
Extracellular ATP regulates phagocytic activity, mitochondrial respiration, and cytokine secretion of human astrocytic cells.
Yang SS, Brooks NAH, Da Silva DE, Gibon J, Islam H, Klegeris A
Exploring neuroglial signaling: diversity of molecules implicated in microglia-to-astrocyte neuroimmune communication.
Mohammad ZB, Yudin SCY, Goldberg BJ, Serra KL, Klegeris A
Diversity of Microglia-Derived Molecules with Neurotrophic Properties That Support Neurons in the Central Nervous System and Other Tissues.
Wiens KR, Wasti N, Ulloa OO, Klegeris A
Psilocin, the Psychoactive Metabolite of Psilocybin, Modulates Select Neuroimmune Functions of Microglial Cells in a 5-HT2 Receptor-Dependent Manner.
Wiens KR, Brooks NAH, Riar I, Greuel BK, Lindhout IA, Klegeris A
Regulation of astrocyte phagocytosis and other physiological functions by molecules endogenous to the central nervous system
Principal investigators: Klegeris, Andis
Keywords: brain physiology; brain homeostasis; glial cell physiology; intercellular signaling; endogenous modulators of glial cell activity; cellular communications; astrocytes; phagocytosis; proteomics; secretome
Therapeutic interventions that alter colitogenic microbiota
Principal investigators: Gibson, Deanna L; Frohlick, Susan E; Ghosh, Sanjoy; Morck, Douglas W; Sly, Laura M; Zandberg, Wesley F
Keywords: Bio Engineered Probiotics; Colonization And Persistence; Commercialization; Drug Development; Enteric Microbes; Gut Microbiome; Inflammatory Bowel Disease; Microbiome-Based Therapeutics; Mucosal Healing; Next Generation Beneficial Microbes
Ultracentrifuge for Subcellular Fractionation
Principal investigators: Wolthers, Kirsten
Regulation of brain glial cell functions by extracellularly released mitochondrial transcription factor A and microparticles
Principal investigators: Klegeris, Andis
Do extracellularly released mitochondrial transcription factor A and cytochrome C function as intercellular signaling molecules of the brain?
Principal investigators: Klegeris, Andis
Identification of novel intercellular signaling molecules of the animal central nervous system
Principal investigators: Klegeris, Andis
Adipose-brain cross-talk in obesity and type 2 diabetes
Principal investigators: Klegeris, Andis; Little, Jonathan P
Keywords: Alzheimer'S Disease; Diabetes; Metabolic Syndrome; Neurodegenerative Disease; Obesity
Interspecies differences in glial secretions contributing to neuronal survival and death
Principal investigators: Klegeris, Andis
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Andis Klegeris and Julien Gibon: 7 shared papers
- Frederic Menard and Andis Klegeris: 2 shared papers
- Sanjoy Ghosh and Andis Klegeris: 1 shared paper
- Biology
- Okanagan - Biology
- Okanagan - Chemistry
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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