Carolyn Brown, University of British Columbia

Research

X-Chromosome Inactivation Heterochromatin Dna Methylation Xist Epigenetics Bioinformatics Ctcf Transcription Factors

Latest papers

The making of a Barr body: the mosaic of factors that eXIST on the mammalian inactive X chromosome.
Biochemistry and cell biology = Biochimie et biologie cellulaire · 2016 · senior author
S100B and neurofibromin immunostaining and X-inactivation patterns of laser-microdissected cells indicate a multicellular origin of some NF1-associated neurofibromas.
Journal of neuroscience research · 2011
Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis.
Cancer research · 2010

All 3 publications

Latest funding

Functional characterization of genomic DNA elements regulating epigenetic silencing
CIHR · 2023 · Nominated PI
$1,250,775
Role of XIST in human X-chromosome inactivation and health
CIHR · 2022 · Nominated PI
$864,450
Canadian Epigenetics, Environment and Health Research Consortium Network Phase II
CIHR · 2019 · Co-investigator
$1,080,000

All 16 grants and awards

3 publications.

01

The making of a Barr body: the mosaic of factors that eXIST on the mammalian inactive X chromosome.

Dixon-McDougall T, Brown C

Biochemistry and cell biology = Biochimie et biologie cellulaire2016Senior author

DOI: 10.1139/bcb-2015-0016 PMID: 26283003

02

S100B and neurofibromin immunostaining and X-inactivation patterns of laser-microdissected cells indicate a multicellular origin of some NF1-associated neurofibromas.

Tucker T, Riccardi VM, Brown C, Fee J, Sutcliffe M, Vielkind J, Wechsler J, Wolkenstein P, Friedman JM

Journal of neuroscience research2011

DOI: 10.1002/jnr.22654 PMID: 21674567

03

Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis.

Cheung KJ, Johnson NA, Affleck JG, Severson T, Steidl C, Ben-Neriah S, Schein J, Morin RD, Moore R, Shah SP, Qian H, Paul JE, Telenius A, Relander T, Lam W, Savage K, Connors JM, Brown C, Marra MA, Gascoyne RD, Horsman DE

Cancer research2010

DOI: 10.1158/0008-5472.can-10-2460 PMID: 20884631

Functional characterization of genomic DNA elements regulating epigenetic silencing

Nominated PICIHR2023Project Grant

Principal investigators: Brown, Carolyn J

Keywords: Bioinformatics; Ctcf; Dna Methylation; Epigenetics; Escape From Silencing; Heterochromatin; Transcription Factors; Transcription Regulation; Transgenes; X-Chromosome Inactivation

$1,250,775

Role of XIST in human X-chromosome inactivation and health

Nominated PICIHR2022Project Grant

Principal investigators: Brown, Carolyn J

Keywords: Crispr-Assisted Rna-Binding Protein Identification (Carpid); Crispr/Cas9; Dna Methylation; Epigenetic Silencing; Heterochromatin; Histone Modifications; Long Non-Coding Rna; X Chromosome; X-Chromosome Inactivation; Xist

$864,450

Canadian Epigenetics, Environment and Health Research Consortium Network Phase II

Co-investigatorCIHR2019Operating Grant: CEEHRC (Epigenetics)

Principal investigators: Hirst, Martin; Bourque, Guillaume

Keywords: Dna; Epigenetics; Health; Knowledge Translation; Network; Outreach; Training

$1,080,000

Genetics and epigenetics of sex differences in placental and fetal development

Co-investigatorCIHR2019Project Grant

Principal investigators: Robinson, Wendy P

Keywords: Dna Methylation; Genetics; Placenta; Sex

$604,350

Functional characterization of genomic DNA elements regulating epigenetic silencing

Nominated PICIHR2018Project Grant

Principal investigators: Brown, Carolyn J

Keywords: Bioinformatics; Ctcf; Dna Methylation; Embryonic Stem Cells; Epigenetic Gene Regulation; Gfp Reporter; Mouse Model; Transcription Factors; X-Chromosome Inactivation; Yy1

$971,550

Role of XIST in human X-chromosome inactivation

Nominated PICIHR2017Project Grant

Principal investigators: Brown, Carolyn J

Keywords: Chromatin Modifications; Crispr/Cas9; Cross-Linked Immunoprecipitation; Dosage Compensation; Facultative Heterochromatin; Long Non-Coding Rna; Rna Modification; Rna-Binding Proteins; X-Chromosome Inactivation; Xist

$963,900

The genetics of sex differences related to perinatal health

Co-investigatorCIHR2017Catalyst Grant: Sex as a Variable in Biomedical Research

Principal investigators: Robinson, Wendy P

Keywords: Placenta; Preterm Birth; Sex; X-Chromosome; X-Chromosome Inactivation

$149,960

Functional characterization of genomic DNA elements regulating epigenetic silencing

Nominated PICIHR2016Project Grant

Principal investigators: Brown, Carolyn J

Keywords: Bac Transgenesis; Dna Methylation; Gene Regulation; Heterochromatin; Mouse Modelling; Sexual Dimorphism; Transcription Factor; X Chromosome; X Inactivation; Yy1

$100,000

The role of long non-coding RNAs in genome regulation

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Brown, Carolyn

$228,000

The Role of XIST in Human X-Chromosome Inactivation

Nominated PICIHR2012Operating Grant

Principal investigators: Brown, Carolyn J

Keywords: Epigenetics; Fish; Heterochromatin; Non-Coding Rna; Reporter Gene Silencing; Rna Binding Proteins; Sirna; X-Chromosome Inactivation; Xist

$763,376

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Department of Medical Genetics
Experimental Therapeutics
Other

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Wan Lam

Faculty

1 shared papers, latest 2010

Christian Steidl

Experimental Therapeutics

1 shared papers, latest 2010

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: X-Chromosome Inactivation Dear Professor Brown, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The making of a Barr body: the mosaic of factors that eXIST on the mammalian inactive X chromosome." (2016), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Functional characterization of genomic DNA elements regulating epigenetic silencing" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]