David Perrin, University of British Columbia

Research

Peptide Chemistry Targeted Therapy Medicinal Chemistry Pet Imaging Radiofluorination Drug Design Macrocycle

Latest papers

Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes.
The Journal of biological chemistry · 2025
Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes.
bioRxiv : the preprint server for biology · 2025
High-Contrast CXCR4-Targeted 18F-PET Imaging Using a Potent and Selective Antagonist.
Molecular pharmaceutics · 2021

All 6 publications

Latest funding

Next-generation GRPR-targeting radiopharmaceuticals with improved in vivo stability and minimized pancreas uptake
CIHR · 2022 · Co-investigator
$523,260
Synthetic amatoxins for applications in targeted therapy and molecular pharmacology
CIHR · 2022 · Nominated PI
$1,063,350
An Open Access Liquid Chromatography Mass Spectrometer for Sample Characterization
NSERC · 2022 · Principal investigator
$150,000

All 42 grants and awards

6 publications.

01

Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes.

Atser MG, Wenyonu CD, Rowe EM, Leung CLK, Cen HH, Queathem ED, Liu LT, Moravcova R, Rogalski J, Perrin D, Crawford P, Foster LJ, Alcazar A, Johnson JD

The Journal of biological chemistry2025

DOI: 10.1016/j.jbc.2025.108398 PMID: 40074083

02

Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes.

Atser MG, Wenyonu CD, Rowe EM, Leung CLK, Cen HH, Queathem ED, Liu LT, Moravcova R, Rogalski J, Perrin D, Crawford P, Foster LJ, Alcazar A, Johnson JD

bioRxiv : the preprint server for biology2025

DOI: 10.1101/2024.10.14.618123 PMID: 39464135

03

High-Contrast CXCR4-Targeted 18F-PET Imaging Using a Potent and Selective Antagonist.

Kwon D, Lozada J, Zhang Z, Zeisler J, Poon R, Zhang C, Roxin Á, Lin KS, Perrin D, Benard F

Molecular pharmaceutics2021

DOI: 10.1021/acs.molpharmaceut.0c00785 PMID: 33253591

04

Microscale radiosynthesis, preclinical imaging and dosimetry study of [18F]AMBF3-TATE: A potential PET tracer for clinical imaging of somatostatin receptors.

Lisova K, Sergeev M, Evans-Axelsson S, Stuparu AD, Beykan S, Collins J, Jones J, Lassmann M, Herrmann K, Perrin D, Lee JT, Slavik R, van Dam RM

Nuclear medicine and biology2018

DOI: 10.1016/j.nucmedbio.2018.04.001 PMID: 29747035

05

A method for selecting modified DNAzymes without the use of modified DNA as a template in PCR.

Renders M, Miller E, Hollenstein M, Perrin D

Chemical communications (Cambridge, England)2015Senior author

DOI: 10.1039/c4cc07588a PMID: 25487111

06

In vitro selection of a DNAzyme with three modified nucleotides.

Hollenstein M, Hipolito C, Lam C, Perrin D

Nucleic acids symposium series (2004)2008Senior author

DOI: 10.1093/nass/nrn037 PMID: 18776259

Next-generation GRPR-targeting radiopharmaceuticals with improved in vivo stability and minimized pancreas uptake

Co-investigatorCIHR2022Project Grant

Principal investigators: Lin, Kuo-Shyan

Keywords: Albumin Binder; Cancer Imaging; Gastrin-Releasing Peptide Receptor; Positron Emission Tomography; Radiopharmaceuticals; Targeted Radioligand Therapy

$523,260

Synthetic amatoxins for applications in targeted therapy and molecular pharmacology

Nominated PICIHR2022Project Grant

Principal investigators: Perrin, David M

Keywords: Amanitin; Antibody Drug Conjugate; Bioconjugation; Medicinal Chemistry; Peptide; Pharmacology; Synthesis; Targeted Therapy; Transcription

$1,063,350

An Open Access Liquid Chromatography Mass Spectrometer for Sample Characterization

Principal investigatorNSERC2022Research Tools and Instruments

Principal investigators: Perrin, David

$150,000

PSMA/CAIX-targeting radioligands to improve the management of clear cell renal cell carcinoma

Co-investigatorCIHR2021Project Grant

Principal investigators: Lin, Kuo-Shyan

Keywords: Cancer Imaging; Carbonic Anhydrase Ix; Positron Emission Tomography; Prostate-Specific Membrane Antigen; Radiopharmaceuticals; Targeted Radioligand Therapy

$730,575

Dual Isotope Theranostics for 18F-PET Imaging and Correlated Targeted Radioligand Therapy

Nominated PICIHR2021Project Grant

Principal investigators: Perrin, David M

Keywords: Chemistry; Peptide; Pet Imaging; Radiofluorination; Radiometallation; Targeted Radiotherapy

$1,139,850

Synthesis of hetero-trifunctional cross linkers for the design and evaluation of antibody-mediated delivery of chimeric protein degraders

Principal investigatorNSERC2021Alliance Grants

Principal investigators: Perrin, David

$330,000

COVID-19 Variant Supplement - Peptide macrocycle decoys against COVID-19 viral spike protein

Nominated PICIHR2021Operating Grant: SARS-CoV-2 variants supplement stream 1

Principal investigators: Perrin, David M

Keywords: Chemistry; Drug Design; Macrocycle; Peptide; Peptide Staple; Protein Recognition

$50,000

Antibody venom conjugates

Principal investigatorNSERC2021Alliance Grants

Principal investigators: Perrin, David

$29,500

Peptide macrocycle decoys against COVID-19 viral spike protein

Nominated PICIHR2020Operating Grant: COVID-19 Rapid Research Funding Opportunity - Therapeutics

Principal investigators: Perrin, David M

Keywords: Chemistry; Drug Design; Macrocycle; Peptide; Peptide Staple; Protein Recognition

$167,056

Detecting Trace Metals in Synthetic and Biological Macromolecules. ICPMS for a Multi-User Facility in Chemistry

Co-investigatorNSERC2020Research Tools and Instruments

Principal investigators: Schafer, Laurel

$150,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Chemistry
Molecular Oncology

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Kuo-Shyan Lin

Molecular Oncology

1 shared papers, latest 2021

Francois Benard

Chemistry

1 shared papers, latest 2021

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Peptide Dear Professor Perrin, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Pyruvate dehydrogenase kinase 1 controls triacylglycerol hydrolysis in cardiomyocytes." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Synthetic amatoxins for applications in targeted therapy and molecular pharmacology" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]