Faculty profile

Hannu Larjava

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ProfessorOral Biological & Medical SciencesUniversity of British Columbia

Hannu Larjava

Professor

Oral Biological & Medical Sciences

Faculty of Dentistry

University of British Columbia

Vancouver, British Columbia, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
9 publications in the last five years, latest in 2025.
Senior (last) author on 6 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (7 CIHR, 1 NSERC), most recently in 2023.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Read how they describe their research on their University of British Columbia profile.

Alpha-V-Beta-6 Integrin Bacterial Biofilm Cytokine Expression Inflammation Junctional Epithelium Periodontal Disease Pocket Epithelium ß6 Integrin Deficiency

Latest papers

Beyond the clot: how the biomolecular landscape of platelet-rich fibrin directs fibroblast functions.
Frontiers in oral health · 2025
Calcified carotid artery atheroma on standard dental radiographs: A public health opportunity for cardiovascular risk reduction.
American journal of preventive cardiology · 2024
Delayed centrifugation weakens the in vitro biological properties of platelet-rich fibrin membranes.
Clinical oral investigations · 2024 · senior author

All 43 publications

Latest funding

Treatment of periodontitis by epidermal growth factor receptor inhibitor
CIHR · 2023 · Nominated PI
$960,076
Treatment of periodontitis by epidermal growth factor receptor inhibitor
CIHR · 2022 · Nominated PI
$100,000
Regulation of neural crest derived progenitor cell niche by epithelial cell derived extracellular vesicles
NSERC · 2017 · Principal investigator
$168,000

All 10 grants and awards

43 publications.

Beyond the clot: how the biomolecular landscape of platelet-rich fibrin directs fibroblast functions.

Bi J, Larjava H, Häkkinen L

Frontiers in oral health2025

DOI: 10.3389/froh.2025.1731949 PMID: 41641152

Calcified carotid artery atheroma on standard dental radiographs: A public health opportunity for cardiovascular risk reduction.

Mai V, Taneja A, Larjava H, Chehroudi B, MacDonald D, Luong C

American journal of preventive cardiology2024

DOI: 10.1016/j.ajpc.2024.100714 PMID: 39206343

Delayed centrifugation weakens the in vitro biological properties of platelet-rich fibrin membranes.

Robin W, Shuichiro K, Leeni K, Rana T, Reginaldo G, Lari H, Larjava H

Clinical oral investigations2024Senior author

DOI: 10.1007/s00784-024-05617-2 PMID: 38514526

Scanning electron microscopic analysis of adherent bacterial biofilms associated with peri-implantitis.

Chang JW, Bi J, Owen G, Shen Y, Haapasalo M, Wiebe C, Tarzemany R, Larjava H

Clinical and experimental dental research2023Senior author

DOI: 10.1002/cre2.741 PMID: 37157917

Spray-dried microparticles of encapsulated gefitinib for slow-release localized treatment of periodontal disease.

Baldelli A, Koivisto L, Oguzlu H, Guo Y, Häkkinen L, Pratap-Singh A, Larjava H

International journal of pharmaceutics2023Senior author

DOI: 10.1016/j.ijpharm.2023.123137 PMID: 37364780

Macromolecular crowding regulates matrix composition and gene expression in human gingival fibroblast cultures.

Ramalingam R, Jiang G, Larjava H, Häkkinen L

Scientific reports2023

DOI: 10.1038/s41598-023-29252-1 PMID: 36739306

Gingival epithelial cell-derived microvesicles activate mineralization in gingival fibroblasts.

Kobayashi S, Bi J, Owen G, Larjava N, Koivisto L, Häkkinen L, Larjava H

Scientific reports2022Senior author

DOI: 10.1038/s41598-022-19732-1 PMID: 36138045

Altered composition of the oral microbiome in integrin beta 6-deficient mouse.

Uehara O, Bi J, Zhuang D, Koivisto L, Abiko Y, Häkkinen L, Larjava H

Journal of oral microbiology2022Senior author

DOI: 10.1080/20002297.2022.2122283 PMID: 36117552

Decontamination of multispecies oral biofilm from rough implant surface by airflow with glycine.

Leung K, Bi J, Giannelis G, Owen G, Larjava H

Clinical and experimental dental research2022Senior author

DOI: 10.1002/cre2.507 PMID: 34704380

Leucocyte- and platelet-rich fibrin regulates expression of genes related to early wound healing in human gingival fibroblasts.

Bi J, Intriago MFB, Koivisto L, Jiang G, Häkkinen L, Larjava H

Journal of clinical periodontology2020Senior author

DOI: 10.1111/jcpe.13293 PMID: 32304115

Treatment of periodontitis by epidermal growth factor receptor inhibitor

Nominated PICIHR2023Project Grant

Principal investigators: Larjava, Hannu S

Keywords: Alpha-V-Beta-6 Integrin; Bacterial Biofilm; Cytokine Expression; Epidermal Growth Factor Receptor; Inflammation; Junctional Epithelium; Molecular Mechanisms; Periodontal Disease; Pocket Epithelium; ß6 Integrin Deficiency

$960,076

Treatment of periodontitis by epidermal growth factor receptor inhibitor

Nominated PICIHR2022Project Grant

Principal investigators: Larjava, Hannu S

$100,000

Regulation of neural crest derived progenitor cell niche by epithelial cell derived extracellular vesicles

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Larjava, Hannu

$168,000

Epithelial alpha-v-beta-6 integrin: critical regulator of periodontal inflammation

Nominated PICIHR2017Project Grant

Principal investigators: Larjava, Hannu S

Keywords: Alpha-V-Beta-6 Integrin; Bacterial Biofilm; Cytokine Expression; Inflammation; Junctional Epithelium; Molecular Mechanisms; Periodontal Disease; Pocket Epithelium; ß6 Integrin Deficiency; ß6 Integrin Knockout Mice

$879,750

Oral mucosa as a source of cells with regenerative potential in skin

Co-investigatorCIHR2016Project Grant

Principal investigators: Hakkinen, Lari

Keywords: Dermal Substitutes; Fibroblasts; Oral Mucosa; Red Duroc Pig Model; Scar Formation; Skin & Connective Tissue; Wound Healing

$852,975

Epithelial alpha-v-beta-6 integrin: critical regulator of periodontal inflammation

Nominated PICIHR2016Project Grant

Principal investigators: Larjava, Hannu S

Keywords: Alpha-V-Beta-6 Integrin; Bacterial Biofilm; Cytokine Expression; Inflammation; Junctional Epithelium; Periodontal Disease; Pocket Epithelium; ß6 Integrin Deficiency; ß6 Integrin Knockout Mice

$100,000

Regulation of hair cycle and wound healing by alpha-v-beta-6 integrin

Nominated PICIHR2011Operating Grant

Principal investigators: Larjava, Hannu S

Keywords: Alpha-V-Beta-6 Integrin; Epidermis; Extracellular Matrix; Hair Cycle; Hair Follicles; Integrins; Keratinocyte Proliferation; Wound Healing

$564,090

Critical role for alpha-v-beta-6 integrin in enamel biomineralization

Nominated PICIHR2009Operating Grant

Principal investigators: Larjava, Hannu S

Keywords: Alpha-V-Beta-6 Integrin; Cell Culture; Epidermis; Experimental Periodontitis; Extracellular Matrix; Wound Healing

$599,708

Molecular Mechanisms in Scar Formation

Co-investigatorCIHR2009Operating Grant

Principal investigators: Hakkinen, Lari

Keywords: Animal Models; Oral Mucosa; Scar; Skin; Wound Healing

$684,904

Critical role for alpha-v-beta-6 integrin in enamel biomineralization

Nominated PICIHR2008Operating Grant: Fall 2008 Priority Announcement (IMHA)

Principal investigators: Larjava, Hannu S

Keywords: Alpha-V-Beta-6 Integrin; Cell Culture; Epidermis; Experimental Periodontitis; Extracellular Matrix; Wound Healing

$100,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Profile data last refreshed on July 30, 2025 from the university directory, publication records and CIHR, NSERC and SSHRC funding.

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Hannu Larjava

Research

Latest papers

Latest funding

Beyond the clot: how the biomolecular landscape of platelet-rich fibrin directs fibroblast functions.

Calcified carotid artery atheroma on standard dental radiographs: A public health opportunity for cardiovascular risk reduction.

Delayed centrifugation weakens the in vitro biological properties of platelet-rich fibrin membranes.

Scanning electron microscopic analysis of adherent bacterial biofilms associated with peri-implantitis.

Spray-dried microparticles of encapsulated gefitinib for slow-release localized treatment of periodontal disease.

Macromolecular crowding regulates matrix composition and gene expression in human gingival fibroblast cultures.

Gingival epithelial cell-derived microvesicles activate mineralization in gingival fibroblasts.

Altered composition of the oral microbiome in integrin beta 6-deficient mouse.

Decontamination of multispecies oral biofilm from rough implant surface by airflow with glycine.

Leucocyte- and platelet-rich fibrin regulates expression of genes related to early wound healing in human gingival fibroblasts.

Treatment of periodontitis by epidermal growth factor receptor inhibitor

Treatment of periodontitis by epidermal growth factor receptor inhibitor

Regulation of neural crest derived progenitor cell niche by epithelial cell derived extracellular vesicles

Epithelial alpha-v-beta-6 integrin: critical regulator of periodontal inflammation

Oral mucosa as a source of cells with regenerative potential in skin

Epithelial alpha-v-beta-6 integrin: critical regulator of periodontal inflammation

Regulation of hair cycle and wound healing by alpha-v-beta-6 integrin

Critical role for alpha-v-beta-6 integrin in enamel biomineralization

Molecular Mechanisms in Scar Formation

Critical role for alpha-v-beta-6 integrin in enamel biomineralization

Frequent collaborators

Christina Luong

David MacDonald

Edward Putnins